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Clinical trials and references on Resveratrol research

Underneath you will find the references and articles used when compiling the web pages discussing the beneficial effects of resveratrol on the various problems experienced, such as breast cancer, prostate cancer, elevated cholesterol, Alzheimer's disease and fighting and retarding aging in general.

Please note that the various references may be used under more than one heading, as some studies may be applicable to various ailments and fields of study.

resveratrol fight aging stay young fight cancers lowers cholesterol on this page


 

Atherosclerosis and resveratrol

  1. Huang Z, Wang C, Wei L, Wang J, Fan Y, Wang L, Wang Y, Chen T., Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells., Biochem Biophys Res Commun. 2008 Sep 26;374(3):517-21.
  2. Lu KT, Ko MC, Chen BY, Huang JC, Hsieh CW, Lee MC, Chiou RY, Wung BS, Peng CH, Yang YL., Neuroprotective Effects of Resveratrol on MPTP-Induced Neuron Loss Mediated by Free Radical Scavenging., J Agric Food Chem. 2008 Jul 11.
  3. Do GM, Kwon EY, Kim HJ, Jeon SM, Ha TY, Park T, Choi MS., Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice., Biochem Biophys Res Commun. 2008 Sep 12;374(1):55-9.
  4. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M., SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase., J Biol Chem. 2008 Jul 18;283(29):20015-26.
  5. Reiter E, Azzi A, Zingg JM., Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cells., Biofactors. 2007;30(2):67-77.
  6. Das S, Das DK., Resveratrol: a therapeutic promise for cardiovascular diseases. Recent Patents Cardiovasc Drug Discov. 2007 Jun;2(2):133-8.
  7. Magrone T, Tafaro A, Jirillo F, Panaro MA, Cuzzuol P, Cuzzuol AC, Pugliese V, Amati L, Jirillo E, Covelli V., Red wine consumption and prevention of atherosclerosis: an in vitro model using human peripheral blood mononuclear cells., Curr Pharm Des. 2007;13(36):3718-25.
  8. Vivancos M, Moreno JJ., Effect of resveratrol, tyrosol and beta-sitosterol on oxidised low-density lipoprotein-stimulated oxidative stress, arachidonic acid release and prostaglandin E2 synthesis by RAW 264.7 macrophages., Br J Nutr. 2008 Jun;99(6):1199-207.
  9. Ahn J, Lee H, Kim S, Ha T., Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes., Biochem Biophys Res Commun. 2007 Dec 28;364(4):972-7.
  10. Tsoupras AB, Fragopoulou E, Nomikos T, Iatrou C, Antonopoulou S, Demopoulos CA., Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells., Mediators Inflamm. 2007;2007:27683.
  11. Ekshyyan VP, Hebert VY, Khandelwal A, Dugas TR., Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production., J Cardiovasc Pharmacol. 2007 Jul;50(1):83-93.
  12. Bertelli AA., Wine, research and cardiovascular disease: instructions for use. Atherosclerosis. 2007 Dec;195(2):242-7.
  13. Cullen JP, Morrow D, Jin Y, von Offenberg Sweeney N, Sitzmann JV, Cahill PA, Redmond EM., Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes., Atherosclerosis. 2007 Nov;195(1):e125-33.
  14. Schmitt CA, Handler N, Heiss EH, Erker T, Dirsch VM., No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells., Atherosclerosis. 2007 Nov;195(1):e58-64.
  15. Cruz MN, Agewall S, Schenck-Gustafsson K, Kublickiene K., Acute dilatation to phytoestrogens and estrogen receptor subtypes expression in small arteries from women with coronary heart disease., Atherosclerosis. 2008 Jan;196(1):49-58.
  16. Fragopoulou E, Nomikos T, Karantonis HC, Apostolakis C, Pliakis E, Samiotaki M, Panayotou G, Antonopoulou S., Biological activity of acetylated phenolic compounds., J Agric Food Chem. 2007 Jan 10;55(1):80-9.
  17. Chow SE, Hshu YC, Wang JS, Chen JK., Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages., J Appl Physiol. 2007 Apr;102(4):1520-7.
  18. Brito PM, Mariano A, Almeida LM, Dinis TC., Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: A role for intracellular glutathione. Chem Biol Interact. 2006 Dec 15;164(3):157-66.
  19. Jun HJ, Chung MJ, Kim SY, Lee HJ, Lee SJ., Non-radioactive and colorimetric quantification of monocyte adhesion to endothelial cells in early atherogenesis. Biotechnol Lett. 2006 Nov;28(22):1805-10.
  20. Sevov M, Elfineh L, Cavelier LB., Resveratrol regulates the expression of LXR-alpha in human macrophages., Biochem Biophys Res Commun. 2006 Sep 29;348(3):1047-54.
  21. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA., Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006 Aug;55(8):2180-91.
  22. Lee KW, Lee HJ., The roles of polyphenols in cancer chemoprevention., Biofactors. 2006;26(2):105-21.
  23. Norata GD, Marchesi P, Passamonti S, Pirillo A, Violi F, Catapano AL., Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice., Atherosclerosis. 2007 Apr;191(2):265-71.
  24. Lu KT, Chiou RY, Chen LG, Chen MH, Tseng WT, Hsieh HT, Yang YL., Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation., J Agric Food Chem. 2006 Apr 19;54(8):3126-31.
  25. Das DK, Maulik N., Resveratrol in cardioprotection: a therapeutic promise of alternative medicine., Mol Interv. 2006 Feb;6(1):36-47.
  26. Kaur G, Roberti M, Raul F, Pendurthi UR., Suppression of human monocyte tissue factor induction by red wine phenolics and synthetic derivatives of resveratrol., Thromb Res. 2007;119(2):247-56.
  27. Wung BS, Hsu MC, Wu CC, Hsieh CW., Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation., Life Sci. 2005 Dec 12;78(4):389-97.
  28. Wang Z, Zou J, Cao K, Hsieh TC, Huang Y, Wu JM., Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels., Int J Mol Med. 2005 Oct;16(4):533-40.
  29. Sbarra V, Ristorcelli E, Petit-Thévenin JL, Teissedre PL, Lombardo D, Vérine A., In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim Biophys Acta. 2005 Sep 5;1736(1):67-76.
  30. Vitrac X, Bornet A, Vanderlinde R, Valls J, Richard T, Delaunay JC, Mérillon JM, Teissédre PL., Determination of stilbenes (delta-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, epsilon-viniferin) in Brazilian wines., J Agric Food Chem. 2005 Jul 13;53(14):5664-9.
  31. Morris BJ., A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer., J Hypertens. 2005 Jul;23(7):1285-309.
  32. Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C., Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells., Biochem Biophys Res Commun. 2005 Jul 22;333(1):21-7.
  33. Delmas D, Jannin B, Latruffe N., Resveratrol: preventing properties against vascular alterations and ageing., Mol Nutr Food Res. 2005 May;49(5):377-95.
  34. Aronis A, Madar Z, Tirosh O., Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis., Free Radic Biol Med. 2005 May 1;38(9):1221-30.
  35. Dulak J., Nutraceuticals as anti-angiogenic agents: hopes and reality., J Physiol Pharmacol. 2005 Mar;56 Suppl 1:51-67.
  36. Locatelli GA, Savio M, Forti L, Shevelev I, Ramadan K, Stivala LA, Vannini V, Hübscher U, Spadari S, Maga G., Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants., Biochem J. 2005 Jul 15;389(Pt 2):259-68.
  37. Auger C, Teissedre PL, Gérain P, Lequeux N, Bornet A, Serisier S, Besançon P, Caporiccio B, Cristol JP, Rouanet JM., Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation., J Agric Food Chem. 2005 Mar 23;53(6):2015-21.
  38. Oak MH, El Bedoui J, Schini-Kerth VB., Antiangiogenic properties of natural polyphenols from red wine and green tea., J Nutr Biochem. 2005 Jan;16(1):1-8.
  39. Caimi G, Carollo C, Lo Presti R., Chronic renal failure: oxidative stress, endothelial dysfunction and wine., Clin Nephrol. 2004 Nov;62(5):331-5.
  40. Fukao H, Ijiri Y, Miura M, Hashimoto M, Yamashita T, Fukunaga C, Oiwa K, Kawai Y, Suwa M, Yamamoto J., Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice., Blood Coagul Fibrinolysis. 2004 Sep;15(6):441-6.
  41. Kollár P, Hotolová H., [Biological effects of resveratrol and other constituents of wine] Ceska Slov Farm. 2003 Nov;52(6):272-81. [Czech.]
  42. Schriever C, Pendland SL, Mahady GB., Red wine, resveratrol, Chlamydia pneumoniae and the French connection., Atherosclerosis. 2003 Dec;171(2):379-80.
  43. Bhavnani BR., Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's., J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):473-82.
  44. de Lorgeril M, Salen P, Guiraud A, Boucher F, de Leiris J., Resveratrol and non-ethanolic components of wine in experimental cardiology., Nutr Metab Cardiovasc Dis. 2003 Apr;13(2):100-3.
  45. Di Santo A, Mezzetti A, Napoleone E, Di Tommaso R, Donati MB, De Gaetano G, Lorenzet R., Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells., J Thromb Haemost. 2003 May;1(5):1089-95.
  46. Zern TL, West KL, Fernandez ML., Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs., J Nutr. 2003 Jul;133(7):2268-72.
  47. Sovak M., Grape Extract, Resveratrol, and Its Analogs: A Review., J Med Food. 2001 Summer;4(2):93-105.
  48. Goldberg DM, Yan J, Soleas GJ., Absorption of three wine-related polyphenols in three different matrices by healthy subjects., Clin Biochem. 2003 Feb;36(1):79-87.
  49. Slater SJ, Seiz JL, Cook AC, Stagliano BA, Buzas CJ., Inhibition of protein kinase C by resveratrol., Biochim Biophys Acta. 2003 Jan 20;1637(1):59-69.
  50. Brito P, Almeida LM, Dinis TC., The interaction of resveratrol with ferrylmyoglobin and peroxynitrite; protection against LDL oxidation., Free Radic Res. 2002 Jun;36(6):621-31.
  51. Ignatowicz E, Baer-Dubowska W., Resveratrol, a natural chemopreventive agent against degenerative diseases., Pol J Pharmacol. 2001 Nov-Dec;53(6):557-69.
  52. Soleas GJ, Grass L, Josephy PD, Goldberg DM, Diamandis EP., A comparison of the anticarcinogenic properties of four red wine polyphenols., Clin Biochem. 2002 Mar;35(2):119-24.
  53. Wang Z, Zou J, Huang Y, Cao K, Xu Y, Wu JM., Effect of resveratrol on platelet aggregation in vivo and in vitro., Chin Med J (Engl). 2002 Mar;115(3):378-80.
  54. Landrault N, Larronde F, Delaunay JC, Castagnino C, Vercauteren J, Merillon JM, Gasc F, Cros G, Teissedre PL., Levels of stilbene oligomers and astilbin in French varietal wines and in grapes during noble rot development., J Agric Food Chem. 2002 Mar 27;50(7):2046-52.
  55. Ratna WN, Simonelli JA., The action of dietary phytochemicals quercetin, catechin, resveratrol and naringenin on estrogen-mediated gene expression., Life Sci. 2002 Feb 15;70(13):1577-89.
  56. Pendurthi UR, Meng F, Mackman N, Rao LV., Mechanism of resveratrol-mediated suppression of tissue factor gene expression., Thromb Haemost. 2002 Jan;87(1):155-62.
  57. Ruef J, Moser M, Kübler W, Bode C., Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells., Cardiovasc Pathol. 2001 Nov-Dec;10(6):311-5.
  58. Wang Z, Huang Y, Zou J, Cao K, Xu Y, Wu JM., Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro., Int J Mol Med. 2002 Jan;9(1):77-9.
  59. Bhavnani BR, Cecutti A, Gerulath A, Woolever AC, Berco M., Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women., Menopause. 2001 Nov-Dec;8(6):408-19.
  60. Wu JM, Wang ZR, Hsieh TC, Bruder JL, Zou JG, Huang YZ., Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine., Int J Mol Med. 2001 Jul;8(1):3-17.
  61. Russo P, Tedesco I, Russo M, Russo GL, Venezia A, Cicala C., Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation., Nutr Metab Cardiovasc Dis. 2001 Feb;11(1):25-9.
  62. Bruder JL, Hsieh T, Lerea KM, Olson SC, Wu JM., Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress., BMC Cell Biol. 2001;2:1.
  63. Heredia A, Davis C, Redfield R., Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol., J Acquir Immune Defic Syndr. 2000 Nov 1;25(3):246-55.
  64. Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D., Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway., Biochem Pharmacol. 2000 Nov 15;60(10):1539-48.
  65. Mizutani K, Ikeda K, Yamori Y., Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats., Biochem Biophys Res Commun. 2000 Jul 21;274(1):61-7.
  66. Fragopoulou E, Nomikos T, Antonopoulou S, Mitsopoulou CA, Demopoulos CA., Separation of biologically active lipids from red wine., J Agric Food Chem. 2000 Apr;48(4):1234-8.
  67. Hsieh TC, Juan G, Darzynkiewicz Z, Wu JM., Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2., Cancer Res. 1999 Jun 1;59(11):2596-601.
  68. Belguendouz L, Frémont L, Gozzelino MT., Interaction of transresveratrol with plasma lipoproteins., Biochem Pharmacol. 1998 Mar 15;55(6):811-6.
  69. Soleas GJ, Diamandis EP, Goldberg DM., Resveratrol: a molecule whose time has come? And gone?, Clin Biochem. 1997 Mar;30(2):91-113.
  70. Pace-Asciak CR, Rounova O, Hahn SE, Diamandis EP, Goldberg DM., Wines and grape juices as modulators of platelet aggregation in healthy human subjects., Clin Chim Acta. 1996 Mar 15;246(1-2):163-82.
  71. Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL., Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits., Life Sci. 1996;59(1):PL15-21.
  72. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM., The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease., Clin Chim Acta. 1995 Mar 31;235(2):207-19.

Breast Cancer and Resveratrol Clinical trials references Resveratrol research

  1. Schlachterman A, Valle F, Wall KM, Azios NG, Castillo L, Morell L, Washington AV, Cubano LA, Dharmawardhane SF., Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model., Transl Oncol. 2008 Mar;1(1):19-27.
  2. Nguyen TH, Mustafa FB, Pervaiz S, Ng FS, Lim LH., ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells., Int J Oncol. 2008 Jul;33(1):81-92.
  3. Wang Y, Ye L, Leung LK., A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol. ,Toxicology. 2008 Jun 27;248(2-3):130-5.
  4. Snyder RM, Yu W, Jia L, Sanders BG, Kline K., Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth., Nutr Cancer. 2008 May-Jun;60(3):401-11.
  5. Murias M, Luczak MW, Niepsuj A, Krajka-Kuzniak V, Zielinska-Przyjemska M, Jagodzinski PP, Jäger W, Szekeres T, Jodynis-Liebert J., Cytotoxic activity of 3,3',4,4',5,5'-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase. ,Toxicol In Vitro. 2008 Aug;22(5):1361-70.
  6. Singh SK, Moretta D, Almaguel F, De León M, De León DD., Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells. ,Growth Factors. 2008 Apr;26(2):92-103.
  7. Zahid M, Gaikwad NW, Ali MF, Lu F, Saeed M, Yang L, Rogan EG, Cavalieri EL., Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol., Free Radic Biol Med. 2008 Jul 15;45(2):136-45.
  8. Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R., Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells., Cell Death Differ. 2008 Aug;15(8):1318-1329.
  9. Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S., Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens., J Steroid Biochem Mol Biol. 2008 May;110(1-2):104-15.
  10. Tang FY, Su YC, Chen NC, Hsieh HS, Chen KS., Resveratrol inhibits migration and invasion of human breast-cancer cells., Mol Nutr Food Res. 2008 Jun;52(6):683-91.
  11. Singh SK, Moretta D, Almaguel F, Wall NR, De León M, De León D., Differential effect of proIGF-II and IGF-II on resveratrol induced cell death by regulating survivin cellular localization and mitochondrial depolarization in breast cancer cells., Growth Factors. 2007 Dec;25(6):363-72.
  12. Dip R, Lenz S, Antignac JP, Le Bizec B, Gmuender H, Naegeli H., Global gene expression profiles induced by phytoestrogens in human breast cancer cells., Endocr Relat Cancer. 2008 Mar;15(1):161-73.
  13. Bader Y, Madlener S, Strasser S, Maier S, Saiko P, Stark N, Popescu R, Huber D, Gollinger M, Erker T, Handler N, Szakmary A, Jäger W, Kopp B, Tentes I, Fritzer-Szekeres M, Krupitza G, Szekeres T., Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds., Oncol Rep. 2008 Mar;19(3):801-10.
  14. Ma Z, Molavi O, Haddadi A, Lai R, Gossage RA, Lavasanifar A., Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol., Cancer Chemother Pharmacol. 2008 Feb 20.
  15. Huang TC, Chang HY, Hsu CH, Kuo WH, Chang KJ, Juan HF., Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B., J Proteome Res. 2008 Apr;7(4):1433-44.
  16. Alkhalaf M, El-Mowafy A, Renno W, Rachid O, Ali A, Al-Attyiah R., Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway., Arch Med Res. 2008 Feb;39(2):162-8.
  17. Khan N, Afaq F, Mukhtar H., Cancer chemoprevention through dietary antioxidants: progress and promise., Antioxid Redox Signal. 2008 Mar;10(3):475-510.
  18. Murias M, Miksits M, Aust S, Spatzenegger M, Thalhammer T, Szekeres T, Jaeger W., Metabolism of resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition., Cancer Lett. 2008 Mar 18;261(2):172-82.
  19. Zahid M, Gaikwad NW, Rogan EG, Cavalieri EL., Inhibition of depurinating estrogen-DNA adduct formation by natural compounds., Chem Res Toxicol. 2007 Dec;20(12):1947-53.
  20. Degner SC, Kemp MQ, Hockings JK, Romagnolo DF., Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid., Nutr Cancer. 2007;59(2):248-57.
  21. Pearce VP, Sherrell J, Lou Z, Kopelovich L, Wright WE, Shay JW., Immortalization of epithelial progenitor cells mediated by resveratrol., Oncogene. 2008 Apr 10;27(17):2365-74.
  22. Wesierska-Gadek J, Kramer MP, Maurer M., Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells., Food Chem Toxicol. 2008 Apr;46(4):1327-33.,
  23. Neves MA, Dinis TC, Colombo G, Sá e Melo ML., Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols., ChemMedChem. 2007 Dec;2(12):1750-62.
  24. Sareen D, Darjatmoko SR, Albert DM, Polans AS., Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer., Mol Pharmacol. 2007 Dec;72(6):1466-75.
  25. Koohi MK, Walther N, Ivell R., A novel molecular assay to discriminate transcriptional effects caused by xenoestrogens., Mol Cell Endocrinol. 2007 Sep 30;276(1-2):45-54.
  26. Vetvicka V, Volny T, Saraswat-Ohri S, Vashishta A, Vancikova Z, Vetvickova J., Glucan and resveratrol complex--possible synergistic effects on immune system., Biomed Pap Med Fac Univ Palacky Olomouc Czech. 2007 Jun;151(1):41-6.
  27. Tang FY, Chiang EP, Sun YC., Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells. J Nutr Biochem. 2008 May;19(5):287-94.
  28. Alkhalaf M., Resveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation. Eur J Cancer Prev. 2007 Aug;16(4):334-41.
  29. Alkhalaf M., Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells., Pharmacology. 2007;80(2-3):134-43.
  30. Marcsek ZL, Kocsis Z, Szende B, Tompa A., Effect of formaldehyde and resveratrol on the viability of Vero, HepG2 and MCF-7 cells., Cell Biol Int. 2007 Oct;31(10):1214-9.
  31. Su JL, Yang CY, Zhao M, Kuo ML, Yen ML., Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem. 2007 Jul 6;282(27):19385-98.
  32. Benitez DA, Pozo-Guisado E, Clementi M, Castellón E, Fernandez-Salguero PM., Non-genomic action of resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway., Br J Cancer. 2007 May 21;96(10):1595-604.
  33. Le Corre L, Chalabi N, Delort L, Bignon YJ, Bernard-Gallon DJ., Differential expression of genes induced by resveratrol in human breast cancer cell lines., Nutr Cancer. 2006;56(2):193-203.
  34. La Vecchia C, Bosetti C., Diet and cancer risk in Mediterranean countries: open issues., Public Health Nutr. 2006 Dec;9(8A):1077-82.
  35. Azios NG, Krishnamoorthy L, Harris M, Cubano LA, Cammer M, Dharmawardhane SF., Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells., Neoplasia. 2007 Feb;9(2):147-58.
  36. Li Y, Liu J, Liu X, Xing K, Wang Y, Li F, Yao L., Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9., Appl Biochem Biotechnol. 2006 Dec;135(3):181-92.
  37. Shibata MA, Akao Y, Shibata E, Nozawa Y, Ito T, Mishima S, Morimoto J, Otsuki Y., Vaticanol C, a novel resveratrol tetramer, reduces lymph node and lung metastases of mouse mammary carcinoma carrying p53 mutation., Cancer Chemother Pharmacol. 2007 Oct;60(5):681-91.
  38. Bader Y, Getoff N., Effect of resveratrol and mixtures of resveratrol and mitomycin C on cancer cells under irradiation., Anticancer Res. 2006 Nov-Dec;26(6B):4403-8.
  39. Landis-Piwowar KR, Milacic V, Chen D, Yang H, Zhao Y, Chan TH, Yan B, Dou QP., The proteasome as a potential target for novel anticancer drugs and chemosensitizers. Drug Resist Updat. 2006 Dec;9(6):263-73.
  40. Whitsett TG Jr, Lamartiniere CA., Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat., Expert Rev Anticancer Ther. 2006 Dec;6(12):1699-706.
  41. Narayanan BA., Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets., Curr Cancer Drug Targets. 2006 Dec;6(8):711-27.
  42. Wu F, Safe S., Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells., J Steroid Biochem Mol Biol. 2007 Jan;103(1):1-9.
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  3. Snyder RM, Yu W, Jia L, Sanders BG, Kline K., Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth., Nutr Cancer. 2008 May-Jun;60(3):401-11.
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  5. Hsieh TC, Wang Z, Deng H, Wu JM., Identification of glutathione sulfotransferase-pi (GSTP1) as a new resveratrol targeting protein (RTP) and studies of resveratrol-responsive protein changes by resveratrol affinity chromatography., Anticancer Res. 2008 Jan-Feb;28(1A):29-36.
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  8. Zahid M, Gaikwad NW, Rogan EG, Cavalieri EL., Inhibition of depurinating estrogen-DNA adduct formation by natural compounds., Chem Res Toxicol. 2007 Dec;20(12):1947-53.
  9. Sallman DA, Chen X, Zhong B, Gilvary DL, Zhou J, Wei S, Djeu JY., Clusterin mediates TRAIL resistance in prostate tumor cells., Mol Cancer Ther. 2007 Nov;6(11):2938-47.
  10. Horvath Z, Marihart-Fazekas S, Saiko P, Grusch M, Ozsüy M, Harik M, Handler N, Erker T, Jaeger W, Fritzer-Szekeres M, Djavan B, Szekeres T., Novel resveratrol derivatives induce apoptosis and cause cell cycle arrest in prostate cancer cell lines., Anticancer Res. 2007 Sep-Oct;27(5A):3459-64.
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  12. Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE., Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms., Cancer Res. 2007 Sep 1;67(17):8396-405.
  13. Shankar S, Chen Q, Siddiqui I, Sarva K, Srivastava RK., Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential. J Mol Signal. 2007 Aug 24;2:7.
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  17. Cardile V, Chillemi R, Lombardo L, Sciuto S, Spatafora C, Tringali C., Antiproliferative activity of methylated analogues of E- and Z-resveratrol., Z Naturforsch [C]. 2007 Mar-Apr;62(3-4):189-95.
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  31. Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, Zervos AS, Carter B, Turkson J, Jove R., Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein., Mol Cancer Ther. 2006 Mar;5(3):621-9.
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  37. Shih A, Zhang S, Cao HJ, Boswell S, Wu YH, Tang HY, Lennartz MR, Davis FB, Davis PJ, Lin HY., Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha., Mol Cancer Ther. 2004 Nov;3(11):1355-64.
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Protein tyrosine kinase resveratrol research

  1. Ma HJ, Cao YK, Liu YX, Wang R, Wu YM., Microinjection of resveratrol into rostral ventrolateral medulla decreases sympathetic vasomotor tone through nitric oxide and intracellular Ca2+ in anesthetized male rats., Acta Pharmacol Sin. 2008 Aug;29(8):906-12.
  2. Venkatesan B, Ghosh-Choudhury N, Das F, Mahimainathan L, Kamat A, Kasinath BS, Abboud HE, Choudhury GG., Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B., FASEB J. 2008 Jun 20.
  3. Chakraborty PK, Mustafi SB, Ganguly S, Chatterjee M, Raha S., Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70., Cancer Sci. 2008 Jun;99(6):1109-16.
  4. Klinge CM, Wickramasinghe NS, Ivanova MM, Dougherty SM., Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells., FASEB J. 2008 Jul;22(7):2185-97.
  5. Lee KW, Kang NJ, Heo YS, Rogozin EA, Pugliese A, Hwang MK, Bowden GT, Bode AM, Lee HJ, Dong Z., Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine., Cancer Res. 2008 Feb 1;68(3):946-55.
  6. Sallman DA, Chen X, Zhong B, Gilvary DL, Zhou J, Wei S, Djeu JY., Clusterin mediates TRAIL resistance in prostate tumor cells., Mol Cancer Ther. 2007 Nov;6(11):2938-47.
  7. Ohshiro K, Rayala SK, El-Naggar AK, Kumar R., Delivery of cytoplasmic proteins to autophagosomes., Autophagy. 2008 Jan-Feb;4(1):104-6.
  8. Ohshiro K, Rayala SK, Kondo S, Gaur A, Vadlamudi RK, El-Naggar AK, Kumar R., Identifying the estrogen receptor coactivator PELP1 in autophagosomes., Cancer Res. 2007 Sep 1;67(17):8164-71.
  9. Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z., Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1., Carcinogenesis. 2007 Sep;28(9):1918-27.
  10. Wu CC, Wu CI, Wang WY, Wu YC., Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins., Planta Med. 2007 May;73(5):439-43.
  11. Su JL, Yang CY, Zhao M, Kuo ML, Yen ML., Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem. 2007 Jul 6;282(27):19385-98.
  12. Kutuk O, Basaga H., Apoptosis signalling by 4-hydroxynonenal: a role for JNK-c-Jun/AP-1 pathway., Redox Rep. 2007;12(1):30-4.
  13. Faber AC, Chiles TC., Resveratrol induces apoptosis in transformed follicular lymphoma OCI-LY8 cells: evidence for a novel mechanism involving inhibition of BCL6 signaling., Int J Oncol. 2006 Dec;29(6):1561-6.
  14. Fulda S, Debatin KM., Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review., Cancer Detect Prev. 2006;30(3):217-23.
  15. Ovesná Z, Kozics K, Bader Y, Saiko P, Handler N, Erker T, Szekeres T., Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines., Oncol Rep. 2006 Sep;16(3):617-24.
  16. Kim AL, Zhu Y, Zhu H, Han L, Kopelovich L, Bickers DR, Athar M., Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways., Exp Dermatol. 2006 Jul;15(7):538-46.
  17. Koo N, Cho D, Kim Y, Choi HJ, Kim KM., Effects of resveratrol on mast cell degranulation and tyrosine phosphorylation of the signaling components of the IgE receptor., Planta Med. 2006 Jun;72(7):659-61.
  18. Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, Zervos AS, Carter B, Turkson J, Jove R., Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein., Mol Cancer Ther. 2006 Mar;5(3):621-9.
  19. Choi HK, Yang JW, Kang KW., Bifunctional effect of resveratrol on the expression of ErbB2 in human breast cancer cell., Cancer Lett. 2006 Oct 28;242(2):198-206.
  20. Fukuda S, Kaga S, Zhan L, Bagchi D, Das DK, Bertelli A, Maulik N., Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1., Cell Biochem Biophys. 2006;44(1):43-9.
  21. Li X, Zhang S, Safe S., Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds., J Steroid Biochem Mol Biol. 2006 Feb;98(2-3):122-32.
  22. Zhang LP, Yin JX, Liu Z, Zhang Y, Wang QS, Zhao J., Effect of resveratrol on L-type calcium current in rat ventricular myocytes., Acta Pharmacol Sin. 2006 Feb;27(2):179-83.
  23. Juan SH, Lee JL, Ho PY, Lee YH, Lee WS., Antiproliferative and antiangiogenic effects of 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, in human umbilical vascular endothelial cells., Eur J Pharmacol. 2006 Jan 13;530(1-2):1-8.
  24. Kutuk O, Poli G, Basaga H., Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1signaling., Toxicol Sci. 2006 Mar;90(1):120-32.
  25. Wung BS, Hsu MC, Wu CC, Hsieh CW., Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways., Pharmacol Res. 2006 Feb;53(2):113-22.
  26. Liu Z, Zhang LP, Ma HJ, Wang C, Li M, Wang QS., Resveratrol reduces intracellular free calcium concentration in rat ventricular myocytes., Sheng Li Xue Bao. 2005 Oct 25;57(5):599-604.
  27. Chan WH, Chang YJ., Dosage effects of resveratrol on ethanol-induced cell death in the human K562 cell line., Toxicol Lett. 2006 Feb 8;161(1):1-9.
  28. Tyagi A, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R., Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells., Carcinogenesis. 2005 Nov;26(11):1978-87.
  29. Morris BJ., A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer., J Hypertens. 2005 Jul;23(7):1285-309.
  30. Das S, Alagappan VK, Bagchi D, Sharma HS, Maulik N, Das DK., Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart., Vascul Pharmacol. 2005 Apr-May;42(5-6):281-9.
  31. Haider UG, Roos TU, Kontaridis MI, Neel BG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM., Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2., Mol Pharmacol. 2005 Jul;68(1):41-8.
  32. Azios NG, Dharmawardhane SF., Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells., Neoplasia. 2005 Feb;7(2):128-40.
  33. Chan WH., Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells., J Cell Biochem. 2005 Apr 15;94(6):1267-79.
  34. Provinciali M, Re F, Donnini A, Orlando F, Bartozzi B, Di Stasio G, Smorlesi A., Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice., Int J Cancer. 2005 May 20;115(1):36-45.
  35. Klinge CM, Blankenship KA, Risinger KE, Bhatnagar S, Noisin EL, Sumanasekera WK, Zhao L, Brey DM, Keynton RS., Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells., J Biol Chem. 2005 Mar 4;280(9):7460-8.
  36. Evers DL, Wang X, Huong SM, Huang DY, Huang ES., 3,4',5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling., Antiviral Res. 2004 Aug;63(2):85-95.
  37. Guastalla JP, Bachelot T, Ray-Coquard I., [Cyclooxygenase 2 and breast cancer. From biological concepts to therapeutic trials], Bull Cancer. 2004 May;91 Spec No:S99-108. [French]
  38. Storz P, Döppler H, Toker A., Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB., Mol Pharmacol. 2004 Oct;66(4):870-9. Epub 2004 Jun 29.
  39. Conte A, Pellegrini S, Tagliazucchi D., Effect of resveratrol and catechin on PC12 tyrosine kinase activities and their synergistic protection from beta-amyloid toxicity., Drugs Exp Clin Res. 2003;29(5-6):243-55.
  40. Reagan-Shaw S, Afaq F, Aziz MH, Ahmad N., Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin., Oncogene. 2004 Jul 1;23(30):5151-60.
  41. Andrieux L, Langouët S, Fautrel A, Ezan F, Krauser JA, Savouret JF, Guengerich FP, Baffet G, Guillouzo A., Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes., Mol Pharmacol. 2004 Apr;65(4):934-43.
  42. Stewart JR, O'Brian CA., Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition., Invest New Drugs. 2004 Apr;22(2):107-17.
  43. Kubota T, Uemura Y, Kobayashi M, Taguchi H., Combined effects of resveratrol and paclitaxel on lung cancer cells., Anticancer Res. 2003 Sep-Oct;23(5A):4039-46.
  44. Woo JH, Lim JH, Kim YH, Suh SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK., Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction., Oncogene. 2004 Mar 11;23(10):1845-53.
  45. Arakaki N, Nagao T, Niki R, Toyofuku A, Tanaka H, Kuramoto Y, Emoto Y, Shibata H, Magota K, Higuti T., Possible role of cell surface H+ -ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells., Mol Cancer Res. 2003 Nov;1(13):931-9.
  46. Lin MT, Yen ML, Lin CY, Kuo ML., Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation., Mol Pharmacol. 2003 Nov;64(5):1029-36.
  47. Stewart JR, Artime MC, O'Brian CA., Resveratrol: a candidate nutritional substance for prostate cancer prevention., J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
  48. Maccaglia A, Mallozzi C, Minetti M., Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells., Biochem Biophys Res Commun. 2003 Jun 6;305(3):541-7.
  49. Liang YC, Tsai SH, Chen L, Lin-Shiau SY, Lin JK., Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells., Biochem Pharmacol. 2003 Apr 1;65(7):1053-60.
  50. Della Ragione F, Cucciolla V, Criniti V, Indaco S, Borriello A, Zappia V., Antioxidants induce different phenotypes by a distinct modulation of signal transduction., FEBS Lett. 2002 Dec 18;532(3):289-94.
  51. Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB., Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation., J Immunol. 2002 Dec 1;169(11):6490-7.
  52. Brownson DM, Azios NG, Fuqua BK, Dharmawardhane SF, Mabry TJ., Flavonoid effects relevant to cancer., J Nutr. 2002 Nov;132(11 Suppl):3482S-3489S.
  53. Tou JS., Differential regulation of neutrophil phospholipase d activity and degranulation., Biochem Biophys Res Commun. 2002 Apr 12;292(4):951-6.
  54. Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML., Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase., Free Radic Biol Med. 2002 Apr 1;32(7):650-62. Erratum in: Free Radic Biol Med 2002 Jul 31;33(1):149. Guis David [corrected to Gius David].
  55. Kong AN, Yu R, Hebbar V, Chen C, Owuor E, Hu R, Ee R, Mandlekar S., Signal transduction events elicited by cancer prevention compounds., Mutat Res. 2001 Sep 1;480-481:231-41.
  56. De Lédinghen V, Monvoisin A, Neaud V, Krisa S, Payrastre B, Bedin C, Desmouličre A, Bioulac-Sage P, Rosenbaum J., Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells., Int J Oncol. 2001 Jul;19(1):83-8.
  57. Yu R, Hebbar V, Kim DW, Mandlekar S, Pezzuto JM, Kong AN., Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways., Mol Pharmacol. 2001 Jul;60(1):217-24.
  58. Shih A, Lin HY, Davis FB, Davis PJ., Thyroid hormone promotes serine phosphorylation of p53 by mitogen-activated protein kinase., Biochemistry. 2001 Mar 6;40(9):2870-8.
  59. She QB, Bode AM, Ma WY, Chen NY, Dong Z., Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase., Cancer Res. 2001 Feb 15;61(4):1604-10.
  60. Bruder JL, Hsieh T, Lerea KM, Olson SC, Wu JM., Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress., BMC Cell Biol. 2001;2:1.
  61. Saijonmaa O, Nyman T, Kosonen R, Fyhrquist F., Upregulation of angiotensin-converting enzyme by vascular endothelial growth factor., Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H885-91.
  62. Lin JK, Tsai SH., Chemoprevention of cancer and cardiovascular disease by resveratrol., Proc Natl Sci Counc Repub China B. 1999 Jul;23(3):99-106.
  63. Palmieri L, Mameli M, Ronca G., Effect of resveratrol and some other natural compounds on tyrosine kinase activity and on cytolysis., Drugs Exp Clin Res. 1999;25(2-3):79-85.
  64. El-Mowafy AM, White RE., Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects., FEBS Lett. 1999 May 14;451(1):63-7.
  65. Lu R, Serrero G., Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells., J Cell Physiol. 1999 Jun;179(3):297-304.
  66. Ferrero ME, Bertelli AE, Fulgenzi A, Pellegatta F, Corsi MM, Bonfrate M, Ferrara F, De Caterina R, Giovannini L, Bertelli A., Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium., Am J Clin Nutr. 1998 Dec;68(6):1208-14.
  67. Kawada N, Seki S, Inoue M, Kuroki T., Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells., Hepatology. 1998 May;27(5):1265-74.
  68. Jayatilake GS, Jayasuriya H, Lee ES, Koonchanok NM, Geahlen RL, Ashendel CL, McLaughlin JL, Chang CJ., Kinase inhibitors from Polygonum cuspidatum., J Nat Prod. 1993 Oct;56(10):1805-10.

Reducing heart attack and stroke injury resveratrol research

  1. Penumathsa SV, Koneru S, Samuel SM, Maulik G, Bagchi D, Yet SF, Menon VP, Maulik N., Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: Role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor., Free Radic Biol Med. 2008 Jul 27.
  2. Lin JF, Lin SM, Chih CL, Nien MW, Su HH, Hu BR, Huang SS, Tsai SK., Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in rats., Life Sci. 2008 Jun 27.
  3. Lekli I, Szabo G, Juhasz B, Das S, Das M, Varga E, Szendrei L, Gesztelyi R, Varadi J, Bak I, Das DK, Tosaki A., Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H859-66.
  4. Burstein B, Maguy A, Clément R, Gosselin H, Poulin F, Ethier N, Tardif JC, Hébert TE, Calderone A, Nattel S., Effects of resveratrol (trans-3,5,4'-trihydroxystilbene) treatment on cardiac remodeling following myocardial infarction., J Pharmacol Exp Ther. 2007 Dec;323(3):916-23.
  5. Cruz MN, Agewall S, Schenck-Gustafsson K, Kublickiene K., Acute dilatation to phytoestrogens and estrogen receptor subtypes expression in small arteries from women with coronary heart disease., Atherosclerosis. 2008 Jan;196(1):49-58. Epub 2007 Mar 23.
  6. Das S, Falchi M, Bertelli A, Maulik N, Das DK., Attenuation of ischemia/reperfusion injury in rats by the anti-inflammatory action of resveratrol., Arzneimittelforschung. 2006;56(10):700-6.
  7. Penumathsa SV, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, Pant R, Menon VP, Otani H, Maulik N., Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat., J Mol Cell Cardiol. 2007 Mar;42(3):508-16.
  8. Vigne P, Frelin C., A low protein diet increases the hypoxic tolerance in Drosophila., PLoS ONE. 2006 Dec 20;1:e56.,
  9. Bezstarosti K, Das S, Lamers JM, Das DK., Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol., J Cell Mol Med. 2006 Oct-Dec;10(4):896-907.
  10. Maulik N., Reactive oxygen species drives myocardial angiogenesis?, Antioxid Redox Signal. 2006 Nov-Dec;8(11-12):2161-8.
  11. Das S, Fraga CG, Das DK., Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB., Free Radic Res. 2006 Oct;40(10):1066-75.
  12. Baur JA, Sinclair DA., Therapeutic potential of resveratrol: the in vivo evidence., Nat Rev Drug Discov. 2006 Jun;5(6):493-506. Epub 2006 May 26.
  13. Bak I, Lekli I, Juhasz B, Nagy N, Varga E, Varadi J, Gesztelyi R, Szabo G, Szendrei L, Bacskay I, Vecsernyes M, Antal M, Fesus L, Boucher F, de Leiris J, Tosaki A., Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts., Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1329-36. Das S, Tosaki A, Bagchi D, Maulik N, Das DK., Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J Pharmacol Exp Ther. 2006 Jun;317(3):980-8.
  14. Fukuda S, Kaga S, Zhan L, Bagchi D, Das DK, Bertelli A, Maulik N., Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1., Cell Biochem Biophys. 2006;44(1):43-9.
  15. Cruz MN, Luksha L, Logman H, Poston L, Agewall S, Kublickiene K., Acute responses to phytoestrogens in small arteries from men with coronary heart disease., Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1969-75.
  16. Morelli R, Das S, Bertelli A, Bollini R, Lo Scalzo R, Das DK, Falchi M., The introduction of the stilbene synthase gene enhances the natural antiradical activity of Lycopersicon esculentum mill., Mol Cell Biochem. 2006 Jan;282(1-2):65-73.
  17. Kaga S, Zhan L, Matsumoto M, Maulik N., Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor., J Mol Cell Cardiol. 2005 Nov;39(5):813-22.
  18. Das S, Alagappan VK, Bagchi D, Sharma HS, Maulik N, Das DK., Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart., Vascul Pharmacol. 2005 Apr-May;42(5-6):281-9.
  19. Das S, Tosaki A, Bagchi D, Maulik N, Das DK., Resveratrol-mediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways., J Pharmacol Exp Ther. 2005 Aug;314(2):762-9.
  20. Szmitko PE, Verma S., Cardiology patient pages. Red wine and your heart., Circulation. 2005 Jan 18;111(2):e10-1.
  21. Das S, Cordis GA, Maulik N, Das DK., Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation., Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H328-35.
  22. Hung LM, Su MJ, Chen JK., Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms., Free Radic Biol Med. 2004 Mar 15;36(6):774-81.
  23. Sato M, Maulik N, Das DK., Cardioprotection with alcohol: role of both alcohol and polyphenolic antioxidants., Ann N Y Acad Sci. 2002 May;957:122-35.
  24. Cui J, Tosaki A, Bertelli AA, Bertelli A, Maulik N, Das DK., Cardioprotection with white wine., Drugs Exp Clin Res. 2002;28(1):1-10.
  25. Imamura G, Bertelli AA, Bertelli A, Otani H, Maulik N, Das DK., Pharmacological preconditioning with resveratrol: an insight with iNOS knockout mice., Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H1996-2003.
  26. Hattori R, Otani H, Maulik N, Das DK., Pharmacological preconditioning with resveratrol: role of nitric oxide., Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H1988-95.
  27. Hale SL, Kloner RA., Effects of resveratrol, a flavinoid found in red wine, on infarct size in an experimental model of ischemia/reperfusion., J Stud Alcohol. 2001 Nov;62(6):730-5.
  28. Russo P, Tedesco I, Russo M, Russo GL, Venezia A, Cicala C., Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation., Nutr Metab Cardiovasc Dis. 2001 Feb;11(1):25-9.
  29. Hung LM, Chen JK, Lee RS, Liang HC, Su MJ., Beneficial effects of astringinin, a resveratrol analogue, on the ischemia and reperfusion damage in rat heart., Free Radic Biol Med. 2001 Apr 15;30(8):877-83.
  30. Bradamante S, Piccinini F, Barenghi L, Bertelli AA, De Jonge R, Beemster P, De Jong JW., Does resveratrol induce pharmacological preconditioning?, Int J Tissue React. 2000;22(1):1-4.
  31. Ballmer PE., [The Mediterranean diet--healthy but and still delicious], Ther Umsch. 2000 Mar;57(3):167-72. [German]
  32. Sato M, Ray PS, Maulik G, Maulik N, Engelman RM, Bertelli AA, Bertelli A, Das DK., Myocardial protection with red wine extract., J Cardiovasc Pharmacol. 2000 Feb;35(2):263-8.
  33. Sato M, Maulik G, Bagchi D, Das DK., Myocardial protection by protykin, a novel extract of trans-resveratrol and emodin., Free Radic Res. 2000 Feb;32(2):135-44.
  34. Ray PS, Maulik G, Cordis GA, Bertelli AA, Bertelli A, Das DK., The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury., Free Radic Biol Med. 1999 Jul;27(1-2):160-9.
  35. Constant J., Alcohol, ischemic heart disease, and the French paradox., Coron Artery Dis. 1997 Oct;8(10):645-9.
  36. Dong W, Li N, Gao D, Zhen H, Zhang X, Li F., Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors., J Vasc Surg. 2008 Jun 21.
  37. Ban JY, Cho SO, Choi SH, Ju HS, Kim JY, Bae K, Song KS, Seong YH., Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo., J Pharmacol Sci. 2008 Jan;106(1):68-77.
  38. Dong W, Gao D, Lin H, Zhang X, Li N, Li F., New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9., Med Hypotheses. 2008;70(1):52-5.
  39. Tsai SK, Hung LM, Fu YT, Cheng H, Nien MW, Liu HY, Zhang FB, Huang SS., Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats., J Vasc Surg. 2007 Aug;46(2):346-53.
  40. Dong W, Gao D, Zhang X., Mitochondria biogenesis induced by resveratrol against brain ischemic stroke., Med Hypotheses. 2007;69(3):700-1.
  41. Mokni M, Limam F, Elkahoui S, Amri M, Aouani E., Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury., Arch Biochem Biophys. 2007 Jan 1;457(1):1-6.
  42. Gao D, Zhang X, Jiang X, Peng Y, Huang W, Cheng G, Song L., Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia-reperfusion in mice., Life Sci. 2006 Apr 25;78(22):2564-70.
  43. Zhuang H, Kim YS, Koehler RC, Doré S., Potential mechanism by which resveratrol, a red wine constituent, protects neurons., Ann N Y Acad Sci. 2003 May;993:276-86; discussion 287-8.
  44. Ikeda K, Negishi H, Yamori Y., Antioxidant nutrients and hypoxia/ischemia brain injury in rodents., Toxicology. 2003 Jul 15;189(1-2):55-61.
  45. Sinha K, Chaudhary G, Gupta YK., Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats., Life Sci. 2002 Jun 28;71(6):655-65.
  46. Bagchi D, Das DK, Tosaki A, Bagchi M, Kothari SC., Benefits of resveratrol in women's health., Drugs Exp Clin Res. 2001;27(5-6):233-48.
  47. Huang SS, Tsai MC, Chih CL, Hung LM, Tsai SK., Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia., Life Sci. 2001 Jul 20;69(9):1057-65.
  48. Wang MJ, Huang HM, Hsieh SJ, Jeng KC, Kuo JS., Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation., J Neuroimmunol. 2001 Jan 1;112(1-2):28-34.

Reducing LDL levels resveratrol research

  1. Do GM, Kwon EY, Kim HJ, Jeon SM, Ha TY, Park T, Choi MS., Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice., Biochem Biophys Res Commun. 2008 Sep 12;374(1):55-9.
  2. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA., Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006 Aug;55(8):2180-91.
  3. Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML., Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress., J Nutr. 2005 Aug;135(8):1911-7.
  4. Rimando AM, Nagmani R, Feller DR, Yokoyama W., Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters., J Agric Food Chem. 2005 May 4;53(9):3403-7.
  5. Zern TL, West KL, Fernandez ML., Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs., J Nutr. 2003 Jul;133(7):2268-72.
  6. Pal S, Ho N, Santos C, Dubois P, Mamo J, Croft K, Allister E., Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells., J Nutr. 2003 Mar;133(3):700-6.
  7. Weisburger JH., Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea., Food Chem Toxicol. 1999 Sep-Oct;37(9-10):943-8.
  8. Frémont L, Belguendouz L, Delpal S., Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci. 1999;64(26):2511-21.

Triglyceride levels and resveratrol resveratrol research

  1. Shan T, Wang Y, Wu T, Guo J, Liu J, Feng J, Xu Z., Porcine adipose triglyceride lipase complementary deoxyribonucleic acid clone, expression pattern, and regulation by resveratrol., J Anim Sci. 2008 Aug;86(8):1781-8.
  2. Cho IJ, Ahn JY, Kim S, Choi MS, Ha TY., Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters., Biochem Biophys Res Commun. 2008 Feb 29;367(1):190-4.
  3. Wang Z, Zou J, Cao K, Hsieh TC, Huang Y, Wu JM., Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels., Int J Mol Med. 2005 Oct;16(4):533-40.
  4. Ilan E, Tirosh O, Madar Z., Triacylglycerol-mediated oxidative stress inhibits nitric oxide production in rat isolated hepatocytes., J Nutr. 2005 Sep;135(9):2090-5.
  5. Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML., Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress., J Nutr. 2005 Aug;135(8):1911-7.
  6. Aronis A, Madar Z, Tirosh O., Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis., Free Radic Biol Med. 2005 May 1;38(9):1221-30.
  7. Miura D, Miura Y, Yagasaki K., Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats., Life Sci. 2003 Aug 1;73(11):1393-400.

Vasorelaxing and lowering heart disease resveratrol research

  1. Soylemez S, Gurdal H, Sepici A, Akar F., The effect of long-term resveratrol treatment on relaxation to estrogen in aortae from male and female rats: Role of nitric oxide and superoxide., Vascul Pharmacol. 2008 Jul 4.
  2. Zamblé A, Martin-Nizard F, Sahpaz S, Hennebelle T, Staels B, Bordet R, Duriez P, Brunet C, Bailleul F., Vasoactivity, antioxidant and aphrodisiac properties of Caesalpinia benthamiana roots., J Ethnopharmacol. 2008 Feb 28;116(1):112-9.
  3. Calderone V, Martelli A, Testai L, Martinotti E, Breschi MC., Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels., Naunyn Schmiedebergs Arch Pharmacol. 2007 Mar;375(1):73-80.
  4. Yoo MY, Oh KS, Lee JW, Seo HW, Yon GH, Kwon DY, Kim YS, Ryu SY, Lee BH., Vasorelaxant effect of stilbenes from rhizome extract of rhubarb (Rheum undulatum) on the contractility of rat aorta., Phytother Res. 2007 Feb;21(2):186-9.
  5. Granados-Soto V., Pleiotropic effects of resveratrol., Drug News Perspect. 2003 Jun;16(5):299-307.
  6. Orallo F, Alvarez E, Camińa M, Leiro JM, Gómez E, Fernández P., The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption., Mol Pharmacol. 2002 Feb;61(2):294-302.
  7. Mizutani K, Ikeda K, Kawai Y, Yamori Y., Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP)., J Nutr Sci Vitaminol (Tokyo). 1999 Jan;45(1):95-106.
  8. Chen CK, Pace-Asciak CR., Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta., Gen Pharmacol. 1996 Mar;27(2):363-6.
  9. Fitzpatrick DF, Hirschfield SL, Coffey RG., Endothelium-dependent vasorelaxing activity of wine and other grape products., Am J Physiol. 1993 Aug;265(2 Pt 2):H774-8.

Collagen formation collagen formation

  1. Mizutani, K., Ikeda, K., Kawai, Y., and Yamori, Y., Resveratrol Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3 Cells., Biochem Biophys Res Commun 253 (1998): 859—863.
  2. Rucinski M, Ziolkowska A, Hochol A, Pucher A, Macchi C, Belloni AS, Nussdorfer GG, Malendowicz LK., Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1alpha gene expression in primary culture of rat calvarial osteoblast-like cells., Int J Mol Med. 2006 Oct;18(4):565-70.
  3. Ziolkowska A, Rucinski M, Pucher A, Tortorella C, Nussdorfer GG, Malendowicz LK., Expression of osteoblast marker genes in rat calvarial osteoblast-like cells, and effects of the endocrine disrupters diphenylolpropane, benzophenone-3, resveratrol and silymarin., Chem Biol Interact. 2006 Dec 15;164(3):147-56.
  4. Chanvitayapongs, S., Draczynska-Lusiak, B., and Sun, A. Y., Amelioration of Oxidative Stress by Antioxidants and Resveratrol in PCI2 Cells., Neuroreport 8 (1997): 1499—1502.
  5. Leung, A., and Mo, Z., Protective Effects of Polydatin, an Active Compound from Polygonum cuspidatum, on Cerebral Ischemia Damage in Rats., Chin Pharm Bull 12 (1996): 128-129.
  6. Nigdikar, S. V., Williams, N. R., Griffin, B. A., and Howard, A. N., Consumption of Red Wine Polyphenols Reduces the Susceptibility of Low-Density Lipoproteins to Oxidation in Vivo., Amer I Clin Nutr 68 (1998): 258—265.
  7. Sato, M., Maulik, C., Bagchi, D., and Das, D. K., Myocardial Protection by Protykin, a Novel Extract of trans-Resveratrol and Emodin., Free Radical Research 32 (2000): 135—144.
  8. Frankel, F., Waterhouse, A. L., and Kinsella, J. F., Inhibition of Human LDL Oxidation by Resveratrol., The Lancet 341 (1993): 1103—1104.
  9. Han, Y. N., Ryu, S. Y., and Han, B. H., Antioxidant Activity of Resveratrol Closely Correlates with its Monoamine Oxidase-A Inhibitory Activity., Arch Pharm Res 13 (1990): 132—135.
Ageless herbal product range

Our Ageless herbal product range

Skin care

  • Healing cream
    • To assist in wound healing while soothing skin complaints – such as eczema and psoriasis, acne and piles and moisturizing and protecting the skin. This product has shown its effectiveness over a wide range of problems and judging from sales over more than a decade – it is the trusted healing cream to help with all mishaps, allergic reactions, irritated, burning, itchy and uncomfortable skin conditions.
  • Face wash
    • This face wash will properly clean your face and remove all impurities and environmental pollutants, without drying the skin. It contains eight herbal extracts to help promote a clear, vital and healthy complexion and a younger looking skin.
  • Moisturizing day cream
    • This day cream is formulated to help fight the signs of aging on various fronts. It helps to reduce free radical damage which, if left unchecked, leads to premature aging. The herbal extracts help to promote cell rejuvenation and regeneration and provide moisture and hydration to the skin.
  • Nourishing night cream
    • This nourishing night cream penetrates the skin extremely well and does not make the skin feel oily. It contains a host of herbal extracts to help in the fight against premature aging and has added vitamin E as well. Apart from the moisturizing effect and the anti-aging properties it also softens and smoothes the skin.
  • Eye gel
    • An effective refreshing eye gel to help reduce puffiness and dark rings around the eyes, while fighting wrinkles and lines. This is a very clever combination of herbal extracts and the base formula has its roots in a clinically proven formula.
  • Mud face mask
    • With this skin treatment product we combined a special selection of herbs in a base of thermal mud with oligoelements. This recommended weekly treatment will boost circulation to the skin, help to fight wrinkles and lines, improve firmness while at the same time improving suppleness and elasticity of the skin.

 

Hair care

  • Shampoo with rosemary extract + 7 other herbals
    • Our shampoo is in a class of its own – and granted – it is far more expensive than cheap supermarket shampoos, but no other shampoo has the active ingredients we have in our shampoo. The rosemary will boost the health of the hair and scalp, while the other seven herbal extracts will help strengthen the hair and make it shine, increase the volume and make it manageable.
  • Rosemary hair treatment conditioner
    • We have found that this hair conditioner should really be used as a conditioning treatment. This then removes the need to condition the hair every time you wash – and can be used once a month. It is a superb hair tonic and helps in the control of sebum secretion of the scalp. Although not formulated for dandruff – the ingredients will assist with this as well, while supporting the health of the scalp.

 

Specialized herbal gels and lotions

  • Hand and body lotion
    • When formulating this hand and body lotion we created a rich nourishing, protecting and reviving lotion, which will not leave the skin oily or tacky, but will create a well moisturized, hydrated and supple skin. After applying this lotion it will quickly be absorbed by the skin, leaving it silky soft, smooth and well moisturized.
  • Stretch mark gel
    • Although nothing can remove already formed stretch marks (only surgery can do that) – thousands of satisfied clients confirm that this gel improves the appearance of old stretch marks. The gel will help in PREVENTING stretch marks (a 92% success rate) and is used with great success by expectant mothers and body builders who may form marks when bulking-up. The formula of this gel is based on clinical studies done in France, to which we added other herbal extracts.
  • Cellulite gel
    • Fighting cellulite is easy with this herbal cellulite gel. It contains a patented extract of Bayberry (Myriceline) and nine other plant extracts and essential oils. The gel will help to get rid of cellulite (which has been clinically proven) and will also help to prevent cellulite from forming. So now it is easy to get your soft body contours back again.

 

Herbal supplements

  • Apple cider vinegar (liquid) with Centella asiatica
    • The health benefits of apple cider vinegar are combined with the therapeutic properties of Centella asiatica. This old folk remedy is still used with great effect by thousands of people daily.
  • Digest capsules
    • If your digestive system is under-par and you struggle with constipation or you simply need to boost the health of your digestive system then this capsule is for you. Fenugreek is a general digestive tonic and psyllium is a magical bulking agent that will help proper bowel movements, without using a laxative.
  • Detox capsules
    • Our modern day lifestyle exposes us to many unwanted additive and our diet also places stress on the body. To help the body get rid of toxins and waste materials naturally we combined fennel, basil, celery and parsley to help the body remove these toxins. It peps-up your metabolism and helps the bladder, kidneys and liver to do their work more effectively.
  • Urinary and bladder health capsules
    • Using an all natural approach, our capsules will help the discomfort and burning urine sensation of urinary tract infection and help clear up foul smelling urine. We combined cranberry, dandelion, uva ursi and vitamin C in a single capsule to effectively fight bladder infections and to stop the burning sensation when urinating.
  • Tri- Mushroom blend capsules
    • If you need an immune system boost then have a look at our combination of maitake, reishi and shiitake mushrooms. These mushrooms have showed to be a great help in boosting the immune system – and form a good nutritional supplement support for HIV/Aids patients and people receiving chemotherapy. Any person with even a slightly compromised immune system may benefit from this supplement.
  • Olive leaf extract capsules
    • This natural detoxifier helps with a variety of ailments and people with chronic fatigue syndrome, infections, glandular fever (Epstein Barr), and even candida and herpes have found it of value. Olive leaf extract helps to fight bacteria, viruses, retroviruses, and protozoa and yeast strains. Apart from fighting all of these problems it also helps to improve kidney function and fights free radicals.
  • Sexual supplement (previously known as Vuka Nkuzi)
    • Men normally don’t admit when they have a declining libido although it is a most common problem. We combine in this supplement seven different natural ingredients to boost sexual health – without any side effects often experienced with such medication. After more than a decade, and thousands of regular Vuka Nkuzi clients we still offer this well priced supplement to boost the libido.

 

Other products

  • Jojoba oil
    • This liquid golden ester not only moisturizes and penetrates the skin but also helps to fight wrinkles and lines while promoting a clear and unblemished skin. Jojoba does not clog the pores but helps to restore skin elasticity and smoothness. It will leave the skin supple and velvety soft without any oiliness and can be used neat on the skin.
  • Almond oil
    • This light and deeply moisturizing oil has a softening effect on the skin and can be used on the face and body. Almond oil has excellent emollient properties and helps to balance water and moisture loss in the skin. It can be used neat on the skin and also makes an excellent massage base.
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Agelesshealth International herbal and essential oils products
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Olinat pure natural facial moisturizing cream
Cellumend anti-cellulite cream
Sanitoets home test kits and testing strips

 


Information contained on this website is for general information purposes only
and must not be used to treat or diagnose medical conditions.


All health problems must be referred to a health care professional.

Statements made regarding the products, ingredients and general information
have not been evaluated by the FDA or SAMCC and should not be seen as health claims.


All ingredients used in our products are safe and are not banned, controlled or restricted.

All products are manufactured in licensed laboratories following strict GMP and ISO standards.

Our site was last updated on 13 July 2017

© Sallamander Concepts 1998 - 2017