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Clinical references

As far as possible we have tried to link our statements to clinical data and publications, which we have listed below.

On the pages where we discuss our clinical trials, we list the sources, but the sources below refer to specific quotes regarding individual ingredients or other related research.

Please note that no part of this website has been evaluated by the American FDA nor any other medical controlling body or institution in the world.

No statement made on this website must be used as any form of medical evaluation, nor used to diagnose or treat any medical condition, and any visitors to this website which may have medical problems, must consult their health practitioners.

If you are looking for a specific topic, please click here to visit our search form which will search our website for any references to your query.


Advanced Drug Delivery Reviews, June 2002, pages 587-606; and Cancer Research, June 2002, pages 3138-3143.


Journal of the European Academy of Dermatology and Venereology, July 2000, pages 280-284.


Cosmetic News, 130, p.30-32


Further reading to illuminate the Friedman test:

Conover, W. J. 1980. Practical Nonparametric Statistics. 2nd ed. New York: John Wiley & Sons. 
Daniel, Wayne W. 1978. Applied Nonparametric Statistics. Boston: Houghton Mifflin. 
Daniel, Wayne W. 1995. Biostatistics. 6th ed. New York: John Wiley & Sons.
Hollander, M. and Wolfe, D. A. 1973. Nonparametric Statistical Methods. New York: John Wiley & Sons. 
Lehmann, E. L. 1975. Nonparametrics: Statistical Methods Based on Ranks. San Francisco: Holden-Day.
Miller, Rupert G. Jr. 1986. Beyond ANOVA, Basics of Applied Statistics. New York: John Wiley & Sons. 
Sokal, Robert R. and Rohlf, F. James. 1995. Biometry. 3rd. ed. New York: W. H. Freeman and Co. 
Zar, Jerrold H. 1996. Biostatistical Analysis. 3rd ed. Upper Saddle River, NJ: Prentice-Hall.


Anderson, L., Lidgren, G., Bohlin, L., Magni, L., Ogren, S., and Afzelius, L., Studies of Swedish marine organisms. I screening of biological activity, Acta Pharm. Suecica, 20(6), 401-414, 1983.


Mabeu, S., Kloareg, B., and Joseleau, J. -P., Fractionation and analysis of fucans from brown algae, Phytochemistry, 29, 2441-2446, 1990.


Brown, D., The herb society of America - New Encyclopedia of Herbs & their uses., Dorling Kindersley Limited, London, 1995.


Bruneton, J. 1995. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris: Lavoisier Publishing. 


Boik, J. 1995. Cancer and Natural Medicine: A Textbook of Basic Science and Clinical Research. Princeton, Minnesota: Oregon Medical Press. 


Sabinsa Corporation. 1997. Current Issues: Newsletter of Sabinsa Corporation, October.


Leung, A.Y. and S. Foster. 1996. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2nd ed. New York: John Wiley & Sons, Inc.


Wichtl, M. and N.G. Bisset (eds.). 1994. Herbal Drugs and Phytopharmaceuticals. Stuttgart: Medpharm Scientific Publishers. 


Moerman, D.E. 1998. Native American Ethnobotany. Portland, OR: Timber Press. 213 - 214. 


Bradley, P.R. (ed.). 1992. British Herbal Compendium, Vol. 1. Bournemouth: British Herbal Medicine Association.


Tyler, V. 1993. The Honest Herbal, 3rd ed. New York: Pharmaceutical Products Press. 


Castleman, M,. The new healing herbs, The classic guide to nature's best medicine, Rodale Inc., 2001.


R. Petras, Gotu kola (Centella asiatica) unpublished monographs, p6.


M. V. R. Appa Rao, et al., Study of mandookapomi and punomovo for their rosayana effect on normal healthy adult, Nagarium, 120, 33-41 July 1969.


M. V. R. Appa Rao, et al., The effect of mandookapomi (Centella asiatica) on the general mental ability (medhya) of mentally retarded children, J. Res. Indian Med., 8, 9-13, 1973.


C. Allegra et al., L'estralto di Centella asiatica nelle fiebopatie degli arti inferiori, Clinica Terapeutica, 99, 506-13, 1981


M. Weiner, Weiner's Herbal, Stein & Day, New York, 1980, 94.


P. Boiteau and A. R. Ratsimamanga, Asiaticoside extracted from Centella asiatica. Its therapeutic uses in the healing of experimental or refractory wounds, leprosy, skin tuberculosis and lupus. Therapie, 11, 125-149, 1956


D'Amelio Sr. Frank S., Botanicals: A phytocosmetic desk refernce, CRC Press, 1999


Foster, S. and V. Tyler. 1999. Tyler's Honest Herbal, 4th ed. New York: The Haworth Herbal Press. 


Reynolds, J.E.F. (ed.). 1989. Martindale: The Extra Pharmacopoeia, 29th ed. London: The Pharmaceutical Press.


Weiss, R.F. 1988. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers. 


Cappelli, R., M. Nicora, T. Di Perri. 1988. Use of extract of Ruscus aculeatus in venous disease in the lower limbs. Drugs Exp Clin Res 14(4):277–283.


Rudofsky, G. 1989. Venentonisierung und Kapillarabdichtung. Die Wirkung der Kombination aus Ruscus-Extrakt und Trimethylhesperidinchalkon bei gesunden Probanden unter Warmebelastung [Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and hesperidine methyl chalcone in healthy probands in heat stress]. Fortschr Med 107(19):52, 55–58. 


Berg, D. 1990. Venenkonstriktion durch lokale Anwendung von Ruscusextrakt. [Venous constriction by local administration of Ruscus extract]. Fortschr Med 108(24):473–476. 


List, P.H. and L. Hörhammer (eds.). 1979. Hagers Handbuch der Pharmazeutischen Praxis , 4th ed. Vol. 6. Berlin-Heidelberg: Springer Verlag. 200–201. 


Pourrat, H., J.L. Lamaison, J.C. Gramain, R. Remuson. 1983. [Isolation and confirmation of the structure by 13C-NMR of the main prosapogenin from Ruscus aculeatus L.] [In French]. Ann Pharm Fr 40(5):451–458.


ElSohly, M.A. et al. 1975. Constituents of Ruscus aculeatus. Lloydia 38(2):106–108. 


Morgan, M. and K. Bone. 1998. Professional Review: Horsechestnut. Medi Herb (65):1–4. 


Yoshikawa, M. et al. 1996. Bioactive saponins and glycosides. III. Horse chestnut. (1): The structures, inhibitory effects on ethanol absorption, and hypoglycemic activity of escins Ia, Ib, IIa, IIb, and IIIa from the seeds of Aesculus hippocastanum L. Chem Pharm Bull (Tokyo) 44(8):1454–1464. 


Konoshima, T. and K.H. Lee. 1986. Antitumor agents, 82. Cytotoxic sapogenols from Aesculus hippocastanum . J Nat Prod 49(4):650–656.


Newall, C.A., L.A. Anderson, J.D. Phillipson. 1996. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press. 166–167. 


Leung, A.Y. and S. Foster. 1996. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2nd ed. New York: John Wiley & Sons, Inc. 304–306. 


Gu X, Beardslee T et al. Identification of IgE-binding proteins in soy lecithin. Int Arch Allergy Immunol, 2001, 126, 3, 218-225.
Mortimer EZ. Anaphylaxis following ingestion of soybean. Pediatr, 1961, 58, 90-92. 
Moroz LA, Yang WH. Kunitz soybean trypsin-inhibitor: a specific allergen in food anaphylaxis N Engl J Med, 1980, 302, 1126-1128. 


Acta Dermato-Venereologica, November 1999, pages 418-421


Hall, DOrothy., Iridology - Personality and health analysis through the iris, 1980, Thomas Nelson Australia


Happi, May 2006, P. 60


Evaluation of the acute toxicity of a synthetic polyalphaolefin-based hydraulic fluid, E.R.Kinkhead, S.S.Henry, B.T.Culpepper, E.C.Kimmel, H.F.Leahy, R.S.Kutzman, Naval Medical Research Institute/Toxicology Department, USA, 14.1.1988.


Nexbase 2006 FG: Preliminary toxicity study by dietary administration to F-344 rats for four weeks, T.J.Lawler, Pharmaco: LSR, UK, 22.12.1993.


Nexbase 2006 FG: Toxicity study by dietary administration to F-344 rats for 13 weeks followed by a 4 week reversibility period, S.Cooper, Pharmaco:LSR, UK, November 1994. 


Huidtesten met Neste Nexbase 2004FG, Nexbase 2006FG en Nexbase 2008FG. Prof. A.Goossens, Contactallergie-Dermatologie, U.Z Sint Rafaël, Leuven, Belgium, May 1999.


3 H- NEXBASE™ 2006FG (3 H-Hydrogenated poly 1-decene) absorption study in the rat after single and repeated doses. B.A John et. Al, Huntingdon Life Sciencies Ltd, UK, 10.2.1999.


3 H- NEXBASE™ 2006FG, In Vitro dermal penetration study in human skin. Huntingdon Life Sciences Ltd, UK, February 1999.3 H- NEXBASE™ 2006FG, Percutaneous absorption study in the rat. Huntingdon Life Sciences Ltd, UK, May 1999.


Evaluation of the anti wrinkle efficacy of cosmetic products, ProDERM Study-No; 99.068-27, ProDERM Institute for Applied Dermatological Research GmbH, Schenefeld/Hamburg, Germany, September 1999.


Certificate of Chemical Analysis of Free Radicals. Henrik Kunttu, University Of Jyväkylä, Department of Chemistry, 1.12.1999.


Evaluation of long term efficacy of cosmetics products, ProDerm study number 99.133-28, order number 200501/1, ProDerm Institute for Applied Dermatological Research GmbH, Schenefeld/Hamburg, Germany, February 2000.


Evaluation of long term efficacy of cosmetic products. ProDerm study number 99.133-28, order number 200501/1, ProDerm Institute for Applied Dermatological Research GmbH, Schenefeld/Hamburg, Germany, March 2000.


Polydecene Cosmetic Application Study, Studio Rigano Srl, Milano, Italy, May 2000.

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