ageless herbal products caucheteux approved quality  

		

   find us on Facebook

"We make living and aging a stunning experience…"

Click HERE to Shop in South Africa

For all official information and updates regarding COVID-19, visit the South African Department of Health's website at www.SAcoronavirus.co.za

Click HERE to Shop for the rest of the World

best quality anti-aging herbal products skin care body care hair care supplements capsules tablets




Clinical trials and references on Resveratrol research

Underneath you will find the references and articles used when compiling the web pages discussing the beneficial effects of resveratrol on the various problems experienced, such as breast cancer, prostate cancer, elevated cholesterol, Alzheimer's disease and fighting and retarding aging in general.

Please note that the various references may be used under more than one heading, as some studies may be applicable to various ailments and fields of study.

resveratrol fight aging stay young fight cancers lowers cholesterol on this page


 

Atherosclerosis and resveratrol

  1. Huang Z, Wang C, Wei L, Wang J, Fan Y, Wang L, Wang Y, Chen T., Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells., Biochem Biophys Res Commun. 2008 Sep 26;374(3):517-21.
  2. Lu KT, Ko MC, Chen BY, Huang JC, Hsieh CW, Lee MC, Chiou RY, Wung BS, Peng CH, Yang YL., Neuroprotective Effects of Resveratrol on MPTP-Induced Neuron Loss Mediated by Free Radical Scavenging., J Agric Food Chem. 2008 Jul 11.
  3. Do GM, Kwon EY, Kim HJ, Jeon SM, Ha TY, Park T, Choi MS., Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice., Biochem Biophys Res Commun. 2008 Sep 12;374(1):55-9.
  4. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M., SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase., J Biol Chem. 2008 Jul 18;283(29):20015-26.
  5. Reiter E, Azzi A, Zingg JM., Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cells., Biofactors. 2007;30(2):67-77.
  6. Das S, Das DK., Resveratrol: a therapeutic promise for cardiovascular diseases. Recent Patents Cardiovasc Drug Discov. 2007 Jun;2(2):133-8.
  7. Magrone T, Tafaro A, Jirillo F, Panaro MA, Cuzzuol P, Cuzzuol AC, Pugliese V, Amati L, Jirillo E, Covelli V., Red wine consumption and prevention of atherosclerosis: an in vitro model using human peripheral blood mononuclear cells., Curr Pharm Des. 2007;13(36):3718-25.
  8. Vivancos M, Moreno JJ., Effect of resveratrol, tyrosol and beta-sitosterol on oxidised low-density lipoprotein-stimulated oxidative stress, arachidonic acid release and prostaglandin E2 synthesis by RAW 264.7 macrophages., Br J Nutr. 2008 Jun;99(6):1199-207.
  9. Ahn J, Lee H, Kim S, Ha T., Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes., Biochem Biophys Res Commun. 2007 Dec 28;364(4):972-7.
  10. Tsoupras AB, Fragopoulou E, Nomikos T, Iatrou C, Antonopoulou S, Demopoulos CA., Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells., Mediators Inflamm. 2007;2007:27683.
  11. Ekshyyan VP, Hebert VY, Khandelwal A, Dugas TR., Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production., J Cardiovasc Pharmacol. 2007 Jul;50(1):83-93.
  12. Bertelli AA., Wine, research and cardiovascular disease: instructions for use. Atherosclerosis. 2007 Dec;195(2):242-7.
  13. Cullen JP, Morrow D, Jin Y, von Offenberg Sweeney N, Sitzmann JV, Cahill PA, Redmond EM., Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes., Atherosclerosis. 2007 Nov;195(1):e125-33.
  14. Schmitt CA, Handler N, Heiss EH, Erker T, Dirsch VM., No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells., Atherosclerosis. 2007 Nov;195(1):e58-64.
  15. Cruz MN, Agewall S, Schenck-Gustafsson K, Kublickiene K., Acute dilatation to phytoestrogens and estrogen receptor subtypes expression in small arteries from women with coronary heart disease., Atherosclerosis. 2008 Jan;196(1):49-58.
  16. Fragopoulou E, Nomikos T, Karantonis HC, Apostolakis C, Pliakis E, Samiotaki M, Panayotou G, Antonopoulou S., Biological activity of acetylated phenolic compounds., J Agric Food Chem. 2007 Jan 10;55(1):80-9.
  17. Chow SE, Hshu YC, Wang JS, Chen JK., Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages., J Appl Physiol. 2007 Apr;102(4):1520-7.
  18. Brito PM, Mariano A, Almeida LM, Dinis TC., Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: A role for intracellular glutathione. Chem Biol Interact. 2006 Dec 15;164(3):157-66.
  19. Jun HJ, Chung MJ, Kim SY, Lee HJ, Lee SJ., Non-radioactive and colorimetric quantification of monocyte adhesion to endothelial cells in early atherogenesis. Biotechnol Lett. 2006 Nov;28(22):1805-10.
  20. Sevov M, Elfineh L, Cavelier LB., Resveratrol regulates the expression of LXR-alpha in human macrophages., Biochem Biophys Res Commun. 2006 Sep 29;348(3):1047-54.
  21. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA., Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006 Aug;55(8):2180-91.
  22. Lee KW, Lee HJ., The roles of polyphenols in cancer chemoprevention., Biofactors. 2006;26(2):105-21.
  23. Norata GD, Marchesi P, Passamonti S, Pirillo A, Violi F, Catapano AL., Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice., Atherosclerosis. 2007 Apr;191(2):265-71.
  24. Lu KT, Chiou RY, Chen LG, Chen MH, Tseng WT, Hsieh HT, Yang YL., Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation., J Agric Food Chem. 2006 Apr 19;54(8):3126-31.
  25. Das DK, Maulik N., Resveratrol in cardioprotection: a therapeutic promise of alternative medicine., Mol Interv. 2006 Feb;6(1):36-47.
  26. Kaur G, Roberti M, Raul F, Pendurthi UR., Suppression of human monocyte tissue factor induction by red wine phenolics and synthetic derivatives of resveratrol., Thromb Res. 2007;119(2):247-56.
  27. Wung BS, Hsu MC, Wu CC, Hsieh CW., Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation., Life Sci. 2005 Dec 12;78(4):389-97.
  28. Wang Z, Zou J, Cao K, Hsieh TC, Huang Y, Wu JM., Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels., Int J Mol Med. 2005 Oct;16(4):533-40.
  29. Sbarra V, Ristorcelli E, Petit-Thévenin JL, Teissedre PL, Lombardo D, Vérine A., In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim Biophys Acta. 2005 Sep 5;1736(1):67-76.
  30. Vitrac X, Bornet A, Vanderlinde R, Valls J, Richard T, Delaunay JC, Mérillon JM, Teissédre PL., Determination of stilbenes (delta-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, epsilon-viniferin) in Brazilian wines., J Agric Food Chem. 2005 Jul 13;53(14):5664-9.
  31. Morris BJ., A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer., J Hypertens. 2005 Jul;23(7):1285-309.
  32. Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C., Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells., Biochem Biophys Res Commun. 2005 Jul 22;333(1):21-7.
  33. Delmas D, Jannin B, Latruffe N., Resveratrol: preventing properties against vascular alterations and ageing., Mol Nutr Food Res. 2005 May;49(5):377-95.
  34. Aronis A, Madar Z, Tirosh O., Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis., Free Radic Biol Med. 2005 May 1;38(9):1221-30.
  35. Dulak J., Nutraceuticals as anti-angiogenic agents: hopes and reality., J Physiol Pharmacol. 2005 Mar;56 Suppl 1:51-67.
  36. Locatelli GA, Savio M, Forti L, Shevelev I, Ramadan K, Stivala LA, Vannini V, Hübscher U, Spadari S, Maga G., Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants., Biochem J. 2005 Jul 15;389(Pt 2):259-68.
  37. Auger C, Teissedre PL, Gérain P, Lequeux N, Bornet A, Serisier S, Besançon P, Caporiccio B, Cristol JP, Rouanet JM., Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation., J Agric Food Chem. 2005 Mar 23;53(6):2015-21.
  38. Oak MH, El Bedoui J, Schini-Kerth VB., Antiangiogenic properties of natural polyphenols from red wine and green tea., J Nutr Biochem. 2005 Jan;16(1):1-8.
  39. Caimi G, Carollo C, Lo Presti R., Chronic renal failure: oxidative stress, endothelial dysfunction and wine., Clin Nephrol. 2004 Nov;62(5):331-5.
  40. Fukao H, Ijiri Y, Miura M, Hashimoto M, Yamashita T, Fukunaga C, Oiwa K, Kawai Y, Suwa M, Yamamoto J., Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice., Blood Coagul Fibrinolysis. 2004 Sep;15(6):441-6.
  41. Kollár P, Hotolová H., [Biological effects of resveratrol and other constituents of wine] Ceska Slov Farm. 2003 Nov;52(6):272-81. [Czech.]
  42. Schriever C, Pendland SL, Mahady GB., Red wine, resveratrol, Chlamydia pneumoniae and the French connection., Atherosclerosis. 2003 Dec;171(2):379-80.
  43. Bhavnani BR., Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's., J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):473-82.
  44. de Lorgeril M, Salen P, Guiraud A, Boucher F, de Leiris J., Resveratrol and non-ethanolic components of wine in experimental cardiology., Nutr Metab Cardiovasc Dis. 2003 Apr;13(2):100-3.
  45. Di Santo A, Mezzetti A, Napoleone E, Di Tommaso R, Donati MB, De Gaetano G, Lorenzet R., Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells., J Thromb Haemost. 2003 May;1(5):1089-95.
  46. Zern TL, West KL, Fernandez ML., Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs., J Nutr. 2003 Jul;133(7):2268-72.
  47. Sovak M., Grape Extract, Resveratrol, and Its Analogs: A Review., J Med Food. 2001 Summer;4(2):93-105.
  48. Goldberg DM, Yan J, Soleas GJ., Absorption of three wine-related polyphenols in three different matrices by healthy subjects., Clin Biochem. 2003 Feb;36(1):79-87.
  49. Slater SJ, Seiz JL, Cook AC, Stagliano BA, Buzas CJ., Inhibition of protein kinase C by resveratrol., Biochim Biophys Acta. 2003 Jan 20;1637(1):59-69.
  50. Brito P, Almeida LM, Dinis TC., The interaction of resveratrol with ferrylmyoglobin and peroxynitrite; protection against LDL oxidation., Free Radic Res. 2002 Jun;36(6):621-31.
  51. Ignatowicz E, Baer-Dubowska W., Resveratrol, a natural chemopreventive agent against degenerative diseases., Pol J Pharmacol. 2001 Nov-Dec;53(6):557-69.
  52. Soleas GJ, Grass L, Josephy PD, Goldberg DM, Diamandis EP., A comparison of the anticarcinogenic properties of four red wine polyphenols., Clin Biochem. 2002 Mar;35(2):119-24.
  53. Wang Z, Zou J, Huang Y, Cao K, Xu Y, Wu JM., Effect of resveratrol on platelet aggregation in vivo and in vitro., Chin Med J (Engl). 2002 Mar;115(3):378-80.
  54. Landrault N, Larronde F, Delaunay JC, Castagnino C, Vercauteren J, Merillon JM, Gasc F, Cros G, Teissedre PL., Levels of stilbene oligomers and astilbin in French varietal wines and in grapes during noble rot development., J Agric Food Chem. 2002 Mar 27;50(7):2046-52.
  55. Ratna WN, Simonelli JA., The action of dietary phytochemicals quercetin, catechin, resveratrol and naringenin on estrogen-mediated gene expression., Life Sci. 2002 Feb 15;70(13):1577-89.
  56. Pendurthi UR, Meng F, Mackman N, Rao LV., Mechanism of resveratrol-mediated suppression of tissue factor gene expression., Thromb Haemost. 2002 Jan;87(1):155-62.
  57. Ruef J, Moser M, Kübler W, Bode C., Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells., Cardiovasc Pathol. 2001 Nov-Dec;10(6):311-5.
  58. Wang Z, Huang Y, Zou J, Cao K, Xu Y, Wu JM., Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro., Int J Mol Med. 2002 Jan;9(1):77-9.
  59. Bhavnani BR, Cecutti A, Gerulath A, Woolever AC, Berco M., Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women., Menopause. 2001 Nov-Dec;8(6):408-19.
  60. Wu JM, Wang ZR, Hsieh TC, Bruder JL, Zou JG, Huang YZ., Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine., Int J Mol Med. 2001 Jul;8(1):3-17.
  61. Russo P, Tedesco I, Russo M, Russo GL, Venezia A, Cicala C., Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation., Nutr Metab Cardiovasc Dis. 2001 Feb;11(1):25-9.
  62. Bruder JL, Hsieh T, Lerea KM, Olson SC, Wu JM., Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress., BMC Cell Biol. 2001;2:1.
  63. Heredia A, Davis C, Redfield R., Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol., J Acquir Immune Defic Syndr. 2000 Nov 1;25(3):246-55.
  64. Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D., Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway., Biochem Pharmacol. 2000 Nov 15;60(10):1539-48.
  65. Mizutani K, Ikeda K, Yamori Y., Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats., Biochem Biophys Res Commun. 2000 Jul 21;274(1):61-7.
  66. Fragopoulou E, Nomikos T, Antonopoulou S, Mitsopoulou CA, Demopoulos CA., Separation of biologically active lipids from red wine., J Agric Food Chem. 2000 Apr;48(4):1234-8.
  67. Hsieh TC, Juan G, Darzynkiewicz Z, Wu JM., Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2., Cancer Res. 1999 Jun 1;59(11):2596-601.
  68. Belguendouz L, Frémont L, Gozzelino MT., Interaction of transresveratrol with plasma lipoproteins., Biochem Pharmacol. 1998 Mar 15;55(6):811-6.
  69. Soleas GJ, Diamandis EP, Goldberg DM., Resveratrol: a molecule whose time has come? And gone?, Clin Biochem. 1997 Mar;30(2):91-113.
  70. Pace-Asciak CR, Rounova O, Hahn SE, Diamandis EP, Goldberg DM., Wines and grape juices as modulators of platelet aggregation in healthy human subjects., Clin Chim Acta. 1996 Mar 15;246(1-2):163-82.
  71. Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL., Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits., Life Sci. 1996;59(1):PL15-21.
  72. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM., The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease., Clin Chim Acta. 1995 Mar 31;235(2):207-19.

Breast Cancer and Resveratrol Clinical trials references Resveratrol research

  1. Schlachterman A, Valle F, Wall KM, Azios NG, Castillo L, Morell L, Washington AV, Cubano LA, Dharmawardhane SF., Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model., Transl Oncol. 2008 Mar;1(1):19-27.
  2. Nguyen TH, Mustafa FB, Pervaiz S, Ng FS, Lim LH., ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells., Int J Oncol. 2008 Jul;33(1):81-92.
  3. Wang Y, Ye L, Leung LK., A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol. ,Toxicology. 2008 Jun 27;248(2-3):130-5.
  4. Snyder RM, Yu W, Jia L, Sanders BG, Kline K., Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth., Nutr Cancer. 2008 May-Jun;60(3):401-11.
  5. Murias M, Luczak MW, Niepsuj A, Krajka-Kuzniak V, Zielinska-Przyjemska M, Jagodzinski PP, Jäger W, Szekeres T, Jodynis-Liebert J., Cytotoxic activity of 3,3',4,4',5,5'-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase. ,Toxicol In Vitro. 2008 Aug;22(5):1361-70.
  6. Singh SK, Moretta D, Almaguel F, De León M, De León DD., Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells. ,Growth Factors. 2008 Apr;26(2):92-103.
  7. Zahid M, Gaikwad NW, Ali MF, Lu F, Saeed M, Yang L, Rogan EG, Cavalieri EL., Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol., Free Radic Biol Med. 2008 Jul 15;45(2):136-45.
  8. Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R., Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells., Cell Death Differ. 2008 Aug;15(8):1318-1329.
  9. Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S., Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens., J Steroid Biochem Mol Biol. 2008 May;110(1-2):104-15.
  10. Tang FY, Su YC, Chen NC, Hsieh HS, Chen KS., Resveratrol inhibits migration and invasion of human breast-cancer cells., Mol Nutr Food Res. 2008 Jun;52(6):683-91.
  11. Singh SK, Moretta D, Almaguel F, Wall NR, De León M, De León D., Differential effect of proIGF-II and IGF-II on resveratrol induced cell death by regulating survivin cellular localization and mitochondrial depolarization in breast cancer cells., Growth Factors. 2007 Dec;25(6):363-72.
  12. Dip R, Lenz S, Antignac JP, Le Bizec B, Gmuender H, Naegeli H., Global gene expression profiles induced by phytoestrogens in human breast cancer cells., Endocr Relat Cancer. 2008 Mar;15(1):161-73.
  13. Bader Y, Madlener S, Strasser S, Maier S, Saiko P, Stark N, Popescu R, Huber D, Gollinger M, Erker T, Handler N, Szakmary A, Jäger W, Kopp B, Tentes I, Fritzer-Szekeres M, Krupitza G, Szekeres T., Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds., Oncol Rep. 2008 Mar;19(3):801-10.
  14. Ma Z, Molavi O, Haddadi A, Lai R, Gossage RA, Lavasanifar A., Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol., Cancer Chemother Pharmacol. 2008 Feb 20.
  15. Huang TC, Chang HY, Hsu CH, Kuo WH, Chang KJ, Juan HF., Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B., J Proteome Res. 2008 Apr;7(4):1433-44.
  16. Alkhalaf M, El-Mowafy A, Renno W, Rachid O, Ali A, Al-Attyiah R., Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway., Arch Med Res. 2008 Feb;39(2):162-8.
  17. Khan N, Afaq F, Mukhtar H., Cancer chemoprevention through dietary antioxidants: progress and promise., Antioxid Redox Signal. 2008 Mar;10(3):475-510.
  18. Murias M, Miksits M, Aust S, Spatzenegger M, Thalhammer T, Szekeres T, Jaeger W., Metabolism of resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition., Cancer Lett. 2008 Mar 18;261(2):172-82.
  19. Zahid M, Gaikwad NW, Rogan EG, Cavalieri EL., Inhibition of depurinating estrogen-DNA adduct formation by natural compounds., Chem Res Toxicol. 2007 Dec;20(12):1947-53.
  20. Degner SC, Kemp MQ, Hockings JK, Romagnolo DF., Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid., Nutr Cancer. 2007;59(2):248-57.
  21. Pearce VP, Sherrell J, Lou Z, Kopelovich L, Wright WE, Shay JW., Immortalization of epithelial progenitor cells mediated by resveratrol., Oncogene. 2008 Apr 10;27(17):2365-74.
  22. Wesierska-Gadek J, Kramer MP, Maurer M., Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells., Food Chem Toxicol. 2008 Apr;46(4):1327-33.,
  23. Neves MA, Dinis TC, Colombo G, Sá e Melo ML., Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols., ChemMedChem. 2007 Dec;2(12):1750-62.
  24. Sareen D, Darjatmoko SR, Albert DM, Polans AS., Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer., Mol Pharmacol. 2007 Dec;72(6):1466-75.
  25. Koohi MK, Walther N, Ivell R., A novel molecular assay to discriminate transcriptional effects caused by xenoestrogens., Mol Cell Endocrinol. 2007 Sep 30;276(1-2):45-54.
  26. Vetvicka V, Volny T, Saraswat-Ohri S, Vashishta A, Vancikova Z, Vetvickova J., Glucan and resveratrol complex--possible synergistic effects on immune system., Biomed Pap Med Fac Univ Palacky Olomouc Czech. 2007 Jun;151(1):41-6.
  27. Tang FY, Chiang EP, Sun YC., Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells. J Nutr Biochem. 2008 May;19(5):287-94.
  28. Alkhalaf M., Resveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation. Eur J Cancer Prev. 2007 Aug;16(4):334-41.
  29. Alkhalaf M., Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells., Pharmacology. 2007;80(2-3):134-43.
  30. Marcsek ZL, Kocsis Z, Szende B, Tompa A., Effect of formaldehyde and resveratrol on the viability of Vero, HepG2 and MCF-7 cells., Cell Biol Int. 2007 Oct;31(10):1214-9.
  31. Su JL, Yang CY, Zhao M, Kuo ML, Yen ML., Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem. 2007 Jul 6;282(27):19385-98.
  32. Benitez DA, Pozo-Guisado E, Clementi M, Castellón E, Fernandez-Salguero PM., Non-genomic action of resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway., Br J Cancer. 2007 May 21;96(10):1595-604.
  33. Le Corre L, Chalabi N, Delort L, Bignon YJ, Bernard-Gallon DJ., Differential expression of genes induced by resveratrol in human breast cancer cell lines., Nutr Cancer. 2006;56(2):193-203.
  34. La Vecchia C, Bosetti C., Diet and cancer risk in Mediterranean countries: open issues., Public Health Nutr. 2006 Dec;9(8A):1077-82.
  35. Azios NG, Krishnamoorthy L, Harris M, Cubano LA, Cammer M, Dharmawardhane SF., Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells., Neoplasia. 2007 Feb;9(2):147-58.
  36. Li Y, Liu J, Liu X, Xing K, Wang Y, Li F, Yao L., Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9., Appl Biochem Biotechnol. 2006 Dec;135(3):181-92.
  37. Shibata MA, Akao Y, Shibata E, Nozawa Y, Ito T, Mishima S, Morimoto J, Otsuki Y., Vaticanol C, a novel resveratrol tetramer, reduces lymph node and lung metastases of mouse mammary carcinoma carrying p53 mutation., Cancer Chemother Pharmacol. 2007 Oct;60(5):681-91.
  38. Bader Y, Getoff N., Effect of resveratrol and mixtures of resveratrol and mitomycin C on cancer cells under irradiation., Anticancer Res. 2006 Nov-Dec;26(6B):4403-8.
  39. Landis-Piwowar KR, Milacic V, Chen D, Yang H, Zhao Y, Chan TH, Yan B, Dou QP., The proteasome as a potential target for novel anticancer drugs and chemosensitizers. Drug Resist Updat. 2006 Dec;9(6):263-73.
  40. Whitsett TG Jr, Lamartiniere CA., Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat., Expert Rev Anticancer Ther. 2006 Dec;6(12):1699-706.
  41. Narayanan BA., Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets., Curr Cancer Drug Targets. 2006 Dec;6(8):711-27.
  42. Wu F, Safe S., Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells., J Steroid Biochem Mol Biol. 2007 Jan;103(1):1-9.
  43. Ebert B, Seidel A, Lampen A., Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 2007 Apr;96(2):227-36.
  44. Feng L, Zhang LF, Yan T, Jin J, Tao WY., [Studies on active substance of anticancer effect in Polygonum cuspidatum], Zhong Yao Cai. 2006 Jul;29(7):689-91. [Chinese]
  45. Breedveld P, Pluim D, Cipriani G, Dahlhaus F, van Eijndhoven MA, de Wolf CJ, Kuil A, Beijnen JH, Scheffer GL, Jansen G, Borst P, Schellens JH., The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models., Mol Pharmacol. 2007 Jan;71(1):240-9.
  46. Ge H, Zhang JF, Guo BS, He B, Wang BY, Wang CQ., [Resveratrol inhibits expression of EMMPRIN from macrophages], Yao Xue Xue Bao. 2006 Jul;41(7):625-30. [Chinese]
  47. Dolfini E, Roncoroni L, Dogliotti E, Sala G, Erba E, Sacchi N, Ghidoni R., Resveratrol impairs the formation of MDA-MB-231 multicellular tumor spheroids concomitant with ceramide accumulation., Cancer Lett. 2007 May 8;249(2):143-7.
  48. Tang HY, Shih A, Cao HJ, Davis FB, Davis PJ, Lin HY., Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Mol Cancer Ther. 2006 Aug;5(8):2034-42.
  49. Lin HY, Lansing L, Merillon JM, Davis FB, Tang HY, Shih A, Vitrac X, Krisa S, Keating T, Cao HJ, Bergh J, Quackenbush S, Davis PJ., Integrin alphaVbeta3 contains a receptor site for resveratrol., FASEB J. 2006 Aug;20(10):1742-4.
  50. Whitsett T, Carpenter M, Lamartiniere CA., Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats., J Carcinog. 2006 May 15;5:15.
  51. Feng L, Jin J, Zhang LF, Yan T, Tao WY., Analysis of the resveratrol-binding protein using phage-displayed random peptide library., Acta Biochim Biophys Sin (Shanghai). 2006 May;38(5):342-8.
  52. Severgnini M, Bicciato S, Mangano E, Scarlatti F, Mezzelani A, Mattioli M, Ghidoni R, Peano C, Bonnal R, Viti F, Milanesi L, De Bellis G, Battaglia C., Strategies for comparing gene expression profiles from different microarray platforms: application to a case-control experiment., Anal Biochem. 2006 Jun 1;353(1):43-56.
  53. Wang Y, Lee KW, Chan FL, Chen S, Leung LK., The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells., Toxicol Sci. 2006 Jul;92(1):71-7.
  54. Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, Zervos AS, Carter B, Turkson J, Jove R., Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein., Mol Cancer Ther. 2006 Mar;5(3):621-9.
  55. Larrosa M, González-Sarrías A, García-Conesa MT, Tomás-Barberán FA, Espín JC., Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities., J Agric Food Chem. 2006 Mar 8;54(5):1611-20.
  56. Choi HK, Yang JW, Kang KW., Bifunctional effect of resveratrol on the expression of ErbB2 in human breast cancer cell., Cancer Lett. 2006 Oct 28;242(2):198-206.
  57. Lanzilli G, Fuggetta MP, Tricarico M, Cottarelli A, Serafino A, Falchetti R, Ravagnan G, Turriziani M, Adamo R, Franzese O, Bonmassar E., Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro., Int J Oncol. 2006 Mar;28(3):641-8.
  58. Vyas S, Asmerom Y, De León DD., Insulin-like growth factor II mediates resveratrol stimulatory effect on cathepsin D in breast cancer cells., Growth Factors. 2006 Mar;24(1):79-87.
  59. Garvin S, Ollinger K, Dabrosin C., Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo., Cancer Lett. 2006 Jan 8;231(1):113-22.
  60. Minutolo F, Sala G, Bagnacani A, Bertini S, Carboni I, Placanica G, Prota G, Rapposelli S, Sacchi N, Macchia M, Ghidoni R., Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells., J Med Chem. 2005 Nov 3;48(22):6783-6.
  61. Nifli AP, Kampa M, Alexaki VI, Notas G, Castanas E., Polyphenol interaction with the T47D human breast cancer cell line., J Dairy Res. 2005;72 Spec No:44-50.
  62. Harris DM, Besselink E, Henning SM, Go VL, Heber D., Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells., Exp Biol Med (Maywood). 2005 Sep;230(8):558-68.
  63. Miller ME, Holloway AC, Foster WG., Benzo-[a]-pyrene increases invasion in MDA-MB-231 breast cancer cells via increased COX-II expression and prostaglandin E2 (PGE2) output., Clin Exp Metastasis. 2005;22(2):149-56.
  64. Blumenstein I, Keserü B, Wolter F, Stein J., The chemopreventive agent resveratrol stimulates cyclic AMP-dependent chloride secretion in vitro., Clin Cancer Res. 2005 Aug 1;11(15):5651-6.
  65. Vyas S, Asmerom Y, De León DD., Resveratrol regulates insulin-like growth factor-II in breast cancer cells., Endocrinology. 2005 Oct;146(10):4224-33.
  66. Guastalla JP, Bachelot T, Ray-Coquard I., [Cyclooxygenase 2 and breast cancer. From biological concepts to clinical trials], Bull Cancer. 2004 May 1;91 Suppl 2:S99-108. Review. [French]
  67. Matsumura A, Ghosh A, Pope GS, Darbre PD., Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol. 2005 Apr;94(5):431-43.
  68. Waite KA, Sinden MR, Eng C., Phytoestrogen exposure elevates PTEN levels., Hum Mol Genet. 2005 Jun 1;14(11):1457-63.
  69. Azios NG, Dharmawardhane SF., Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells., Neoplasia. 2005 Feb;7(2):128-40.
  70. Monthakantirat O, De-Eknamkul W, Umehara K, Yoshinaga Y, Miyase T, Warashina T, Noguchi H., Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines., J Nat Prod. 2005 Mar;68(3):361-4.
  71. Le Corre L, Chalabi N, Delort L, Bignon YJ, Bernard-Gallon DJ., Resveratrol and breast cancer chemoprevention: molecular mechanisms., Mol Nutr Food Res. 2005 May;49(5):462-71.
  72. Levi F, Pasche C, Lucchini F, Ghidoni R, Ferraroni M, La Vecchia C., Resveratrol and breast cancer risk., Eur J Cancer Prev. 2005 Apr;14(2):139-42.
  73. Rodrigue CM, Porteu F, Navarro N, Bruyneel E, Bracke M, Romeo PH, Gespach C, Garel MC., The cancer chemopreventive agent resveratrol induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities., Oncogene. 2005 May 5;24(20):3274-84.
  74. Pozo-Guisado E, Merino JM, Mulero-Navarro S, Lorenzo-Benayas MJ, Centeno F, Alvarez-Barrientos A, Fernandez-Salguero PM., Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB., Int J Cancer. 2005 May 20;115(1):74-84. Erratum in: Int J Cancer. 2005 Oct 10;116(6):1004. Salguero, Pedro M Fernandez [corrected to Fernandez-Salguero, Pedro M].
  75. Wietzke JA, Ward EC, Schneider J, Welsh J., Regulation of the human vitamin D3 receptor promoter in breast cancer cells is mediated through Sp1 sites., Mol Cell Endocrinol. 2005 Jan 31;230(1-2):59-68.
  76. Manson MM, Farmer PB, Gescher A, Steward WP., Innovative agents in cancer prevention., Recent Results Cancer Res. 2005;166:257-75.
  77. Kim H, Hall P, Smith M, Kirk M, Prasain JK, Barnes S, Grubbs C., Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent., J Nutr. 2004 Dec;134(12 Suppl):3445S-3452S.
  78. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y., Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.
  79. Bianco NR, Chaplin LJ, Montano MM., Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage. Biochem J. 2005 Jan 1;385(Pt 1):279-87.
  80. Zhang S, Cao HJ, Davis FB, Tang HY, Davis PJ, Lin HY., Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br J Cancer. 2004 Jul 5;91(1):178-85.
  81. Simopoulos AP., The traditional diet of Greece and cancer., Eur J Cancer Prev. 2004 Jun;13(3):219-30. Laux MT, Aregullin M, Berry JP, Flanders JA, Rodriguez E., Identification of a p53-dependent pathway in the induction of apoptosis of human breast cancer cells by the natural product, resveratrol., J Altern Complement Med. 2004 Apr;10(2):235-9.
  82. Le Corre L, Fustier P, Chalabi N, Bignon YJ, Bernard-Gallon D., Effects of resveratrol on the expression of a panel of genes interacting with the BRCA1 oncosuppressor in human breast cell lines., Clin Chim Acta. 2004 Jun;344(1-2):115-21.
  83. Sala G, Minutolo F, Macchia M, Sacchi N, Ghidoni R., Resveratrol structure and ceramide-associated growth inhibition in prostate cancer cells., Drugs Exp Clin Res. 2003;29(5-6):263-9.
  84. Gehm BD, Levenson AS, Liu H, Lee EJ, Amundsen BM, Cushman M, Jordan VC, Jameson JL., Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2., J Steroid Biochem Mol Biol. 2004 Mar;88(3):223-34.
  85. Cooray HC, Janvilisri T, van Veen HW, Hladky SB, Barrand MA., Interaction of the breast cancer resistance protein with plant polyphenols., Biochem Biophys Res Commun. 2004 Apr 23;317(1):269-75.
  86. Jo EH, Hong HD, Ahn NC, Jung JW, Yang SR, Park JS, Kim SH, Lee YS, Kang KS., Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell., J Agric Food Chem. 2004 Mar 24;52(6):1715-9.
  87. Cheung CY, Chen J, Chang TK., Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells., J Pharmacol Toxicol Methods. 2004 Mar-Apr;49(2):97-104.
  88. Pozo-Guisado E, Lorenzo-Benayas MJ, Fernández-Salguero PM., Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation., Int J Cancer. 2004 Mar 20;109(2):167-73.
  89. Fulda S, Debatin KM., Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res. 2004 Jan 1;64(1):337-46.
  90. Kim YA, Choi BT, Lee YT, Park DI, Rhee SH, Park KY, Choi YH., Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells., Oncol Rep. 2004 Feb;11(2):441-6.
  91. Hose CD, Hollingshead M, Sausville EA, Monks A., Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity., Mol Cancer Ther. 2003 Dec;2(12):1265-72.
  92. Scarlatti F, Sala G, Somenzi G, Signorelli P, Sacchi N, Ghidoni R., Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling., FASEB J. 2003 Dec;17(15):2339-41.
  93. Fustier P, Le Corre L, Chalabi N, Vissac-Sabatier C, Communal Y, Bignon YJ, Bernard-Gallon DJ., Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines., Br J Cancer. 2003 Jul 7;89(1):168-72.
  94. Aziz MH, Kumar R, Ahmad N., Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review)., Int J Oncol. 2003 Jul;23(1):17-28.
  95. El-Mowafy AM, Alkhalaf M., Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis. 2003 May;24(5):869-73.
  96. Roy M, Chakraborty S, Siddiqi M, Bhattacharya RK., Induction of Apoptosis in Tumor Cells by Natural Phenolic Compounds., Asian Pac J Cancer Prev. 2002;3(1):61-67.
  97. Wietzke JA, Welsh J., Phytoestrogen regulation of a Vitamin D3 receptor promoter and 1,25-dihydroxyvitamin D3 actions in human breast cancer cells., J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):149-57.
  98. Klinge CM, Risinger KE, Watts MB, Beck V, Eder R, Jungbauer A., Estrogenic activity in white and red wine extracts., J Agric Food Chem. 2003 Mar 26;51(7):1850-7.
  99. Levenson AS, Gehm BD, Pearce ST, Horiguchi J, Simons LA, Ward JE 3rd, Jameson JL, Jordan VC., Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha., Int J Cancer. 2003 May 1;104(5):587-96.
  100. Schmitt E, Lehmann L, Metzler M, Stopper H., Hormonal and genotoxic activity of resveratrol., Toxicol Lett. 2002 Dec 15;136(2):133-42.
  101. Brownson DM, Azios NG, Fuqua BK, Dharmawardhane SF, Mabry TJ., Flavonoid effects relevant to cancer., J Nutr. 2002 Nov;132(11 Suppl):3482S-3489S.
  102. Ding XZ, Adrian TE., Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells., Pancreas. 2002 Nov;25(4):e71-6.
  103. Pozo-Guisado E, Alvarez-Barrientos A, Mulero-Navarro S, Santiago-Josefat B, Fernandez-Salguero PM., The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycle., Biochem Pharmacol. 2002 Nov 1;64(9):1375-86.
  104. Banerjee S, Bueso-Ramos C, Aggarwal BB., Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res. 2002 Sep 1;62(17):4945-54.
  105. Levenson AS, Kliakhandler IL, Svoboda KM, Pease KM, Kaiser SA, Ward JE 3rd, Jordan VC., Molecular classification of selective oestrogen receptor modulators on the basis of gene expression profiles of breast cancer cells expressing oestrogen receptor alpha., Br J Cancer. 2002 Aug 12;87(4):449-56.
  106. Dubuisson JG, Dyess DL, Gaubatz JW., Resveratrol modulates human mammary epithelial cell O-acetyltransferase, sulfotransferase, and kinase activation of the heterocyclic amine carcinogen N-hydroxy-PhIP., Cancer Lett. 2002 Aug 8;182(1):27-32.
  107. Levenson AS, Svoboda KM, Pease KM, Kaiser SA, Chen B, Simons LA, Jovanovic BD, Dyck PA, Jordan VC., Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor., Cancer Res. 2002 Aug 1;62(15):4419-26.
  108. Kim HJ, Chang EJ, Bae SJ, Shim SM, Park HD, Rhee CH, Park JH, Choi SW., Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactiflora., Arch Pharm Res. 2002 Jun;25(3):293-9.
  109. Eng ET, Williams D, Mandava U, Kirma N, Tekmal RR, Chen S., Anti-aromatase chemicals in red wine., Ann N Y Acad Sci. 2002 Jun;963:239-46.
  110. Bruggisser R, von Daeniken K, Jundt G, Schaffner W, Tullberg-Reinert H., Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay. Planta Med. 2002 May;68(5):445-8.
  111. Bove K, Lincoln DW, Tsan MF., Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo., Biochem Biophys Res Commun. 2002 Mar 8;291(4):1001-5.
  112. Serrero G, Lu R., Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells., Antioxid Redox Signal. 2001 Dec;3(6):969-79.,
  113. Simopoulos AP., The Mediterranean diets: What is so special about the diet of Greece? The scientific evidence., J Nutr. 2001 Nov;131(11 Suppl):3065S-73S.
  114. Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM., Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models., Cancer Res. 2001 Oct 15;61(20):7456-63.
  115. Lee JE, Safe S., Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells., Biochem Pharmacol. 2001 Oct 15;62(8):1113-24.
  116. Sgambato A, Ardito R, Faraglia B, Boninsegna A, Wolf FI, Cittadini A., Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage., Mutat Res. 2001 Sep 20;496(1-2):171-80.
  117. Soleas GJ, Goldberg DM, Grass L, Levesque M, Diamandis EP., Do wine polyphenols modulate p53 gene expression in human cancer cell lines?, Clin Biochem. 2001 Jul;34(5):415-20.
  118. Pervaiz S., Resveratrol--from the bottle to the bedside?, Leuk Lymphoma. 2001 Feb;40(5-6):491-8.
  119. Nakagawa H, Kiyozuka Y, Uemura Y, Senzaki H, Shikata N, Hioki K, Tsubura A., Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator., J Cancer Res Clin Oncol. 2001 Apr;127(4):258-64.
  120. Cuendet M, Pezzuto JM., The role of cyclooxygenase and lipoxygenase in cancer chemoprevention., Drug Metabol Drug Interact. 2000;17(1-4):109-57.
  121. Huber J., [Phytoestrogens and SERMS, alternatives to classical hormone therapy?] Ther Umsch. 2000 Oct;57(10):651-4. [German]
  122. Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C, Kouroumalis E, Martin PM, Castanas E., Potent inhibitory action of red wine polyphenols on human breast cancer cells., J Cell Biochem. 2000 Jun 6;78(3):429-41.
  123. Basly JP, Marre-Fournier F, Le Bail JC, Habrioux G, Chulia AJ., Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol., Life Sci. 2000 Jan 21;66(9):769-77.
  124. Subbaramaiah K, Michaluart P, Chung WJ, Tanabe T, Telang N, Dannenberg AJ., Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells., Ann N Y Acad Sci. 1999;889:214-23.
  125. Weisburger JH., Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea., Food Chem Toxicol. 1999 Sep-Oct;37(9-10):943-8.
  126. Ulsperger E, Hamilton G, Raderer M, Baumgartner G, Hejna M, Hoffmann O, Mallinger R., Resveratrol pretreatment desensitizes AHTO-7 human osteoblasts to growth stimulation in response to carcinoma cell supernatants., Int J Oncol. 1999 Nov;15(5):955-9.
  127. Gottlieb N., "Soybean" in a Haystack? pinpointing an anti-cancer effect., J Natl Cancer Inst. 1999 Oct 6;91(19):1610-2.
  128. Hsieh TC, Burfeind P, Laud K, Backer JM, Traganos F, Darzynkiewicz Z, Wu JM., Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials., Int J Oncol. 1999 Aug;15(2):245-52.
  129. Lu R, Serrero G., Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179(3):297-304.
  130. Subbaramaiah K, Chung WJ, Michaluart P, Telang N, Tanabe T, Inoue H, Jang M, Pezzuto JM, Dannenberg AJ., Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells., J Biol Chem. 1998 Aug 21;273(34):21875-82.
  131. Clément MV, Hirpara JL, Chawdhury SH, Pervaiz S., Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells., Blood. 1998 Aug 1;92(3):996-1002.
  132. Kopp P., Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?, Eur J Endocrinol. 1998 Jun;138(6):619-20.
  133. Fang N, Casida JE., Anticancer action of cubé insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities., Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3380-4.
  134. Mgbonyebi OP, Russo J, Russo IH., Antiproliferative effect of synthetic resveratrol on human breast epithelial cells., Int J Oncol. 1998 Apr;12(4):865-9.
  135. Gehm BD, McAndrews JM, Chien PY, Jameson JL., Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor., Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14138-43.

Chemopreventive Clinical trials references Resveratrol research

  1. Langcake,P. and Pryce,R.J. (1976) The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury. Physiol. Plant Pathol., 9, 77–86.
  2. Nonomura,S., Kanagawa,H. and Makimoto,A. (1963) Chemical constituents of polygonaceous plants. I. Studies on the components of Ko-jo-kon (Polygonum cuspidatum SIEB et ZUCC). Yakugaku Zasshi, 83, 983–988.
  3. Siemann,E.H. and Creasy,L.L. (1992) Concentration of phytoalexin resveratrol in wine. Am. J. Enol. Vitic., 43, 49–52.
  4. Creasy,L.L. and Coffee,M. (1988) Phytoalexin production potential of grape berries. J. Am. Soc. Hort. Sci., 113, 230–234.
  5. Foroozesh,M., Primrose,G., Guo,Z., Bell,L.C., Alworth,W.L. and Guengerich,F.P. (1997) Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes. Chem. Res. Toxicol., 10, 91–102.
  6. Chanvitayapongs,S., Draczynska-Lusiak,B. and Sun,A.Y. (1997) Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells. Neuroreport, 8, 1499–1502.
  7. Belguendouz,L., Fremont,L. and Linard,A. (1997) Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochem. Pharmacol., 53, 1347–1355.
  8. Fauconneau,B., Waffo-Teguo,P., Huguet,F., Barrier,L., Decendit,A. and Merillon,J.M. (1997) Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests. Life Sci., 61, 2103–2110.
  9. Frankel,E.N., Waterhouse,A.L. and Kinsella,J.E. (1993) Inhibition of human LDL oxidation by resveratrol (letter). Lancet, 341, 1103–1104.
  10. Pace-Asciak,C.R., Hahn,S., Diamandis,E.P., Soleas,G. and Goldberg,D.M. (1995) The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin. Chim. Acta, 235, 207–219.
  11. Kimura,Y., Okuda,H. and Arichi,S. (1985) Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim. Biophys. Acta, 834, 275–278.
  12. Bertelli,A.A., Giovannini,L., Giannessi,D., Migliori,M., Bernini,W., Fregoni,M. and Bertelli,A. (1995) Antiplatelet activity of synthetic and natural resveratrol in red wine. Int. J. Tissue React., 17, 1–3.
  13. Chung,M.I., Teng,C.M., Cheng,K.L., Ko,F.N. and Lin,C.N. (1992) An antiplatelet principle of Veratrum formosanum. Planta Med., 58, 274–276.
  14. Belguendouz,L., Fremont,L. and Gozzelino,M.T. (1998) Interaction of transresveratrol with plasma lipoproteins. Biochem. Pharmacol., 55, 811–816.
  15. Jang,M., Cai,L., Udeani,G.O., Slowing,K.V., Thomas,C.F., Beecher,C.W., Fong,H.H., Farnsworth,N.R., Kinghorn,A.D., Mehta,R.G., Moon,R.C. and Pezzuto,J.M. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275, 218–220.
  16. Johnson,J.L. and Maddipati,K.R. (1998) Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat., 56, 131–143.
  17. Rotondo,S., Rajtar,G., Manarini,S., Celardo,A., Rotillo,D., de Gaetano,G., Evangelista,V. and Cerletti,C. (1998) Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br. J. Pharmacol., 123, 1691–1699.
  18. Chen,C.K. and Pace-Asciak,C.R. (1996) Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen. Pharmacol., 27, 363–366.
  19. Celotti,E., Ferrarini,R., Zironi,R. and Conte,L.S. (1996) Resveratrol content of some wines obtained from dried Valpolicella grapes: Recioto and Amarone. J. Chromatogr. A, 730, 47–52.
  20. Gehm,B.D., McAndrews,J.M., Chien,P.Y. and Jameson,J.L. (1997) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl Acad. Sci. USA, 94, 14138–14143.
  21. Mizutani,K., Ikeda,K., Kawai,Y. and Yamori,Y. (1998) Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochem. Biophys. Res. Commun., 253, 859–863.
  22. Ragazzi,E., Froldi,G. and Fassina,G. (1988) Resveratrol activity on guinea pig isolated trachea from normal and albumin-sensitized animals. Pharmacol. Res. Commun., 20 (suppl. 5), 79–82.
  23. Han,Y.N., Ryn,S.Y. and Han,B.H. (1990) Antioxidant activity of resveratrol closely correlates with its monoamine oxidase-A inhibitory activity. Arch. Pharmacol. Res., 13, 132.
  24. Murakami,S., Arai,I., Muramatsu,M., Otomo,S., Baba,K., Kido,T. and Kozawa,M. (1992) Effect of stilbene derivatives on gastric H+, K(+)-ATPase. Biochem. Pharmacol., 44, 1947–1951.
  25. Jayatilake,G.S., Jayasuriya,H., Lee,E.S., Koonchanok,N.M., Geahlen,R.L., Ashendel,C.L., McLaughlin,J.L. and Chang,C.J. (1993) Kinase inhibitors from Polygonum cuspidatum. J. Nat. Prod., 56, 1805–1810.
  26. Ben Av,P., Crofford,L.J., Wilder,R.L. and Hla,T. (1995) Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett., 372, 83–87.
  27. Goodwin,J.S. and Ceuppens,J. (1983) Regulation of the immune response by prostaglandins. J. Clin. Immunol., 3, 295–315.
  28. Sheng,H., Shao,J., Morrow,J.D., Beauchamp,R.D. and DuBois,R.N. (1998) Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res., 58, 362–366.
  29. Shin,N.H., Ryu,S.Y., Lee,H., Min,K.R. and Kim,Y. (1998) Inhibitory effects of hydroxystilbenes on cyclooxygenase from sheep seminal vesicles. Planta Med., 64, 283–284.
  30. Jang,M. and Pezzuto,J.M. (1998) Effects of resveratrol on 12-O-tetradecanoylphorbol-13-acetate-induced oxidative events and gene expression in mouse skin. Cancer Lett., 134, 81–89.
  31. Subbaramaiah,K., Chung,W.J., Michaluart,P., Telang,N., Tanabe,T., Inoue,H., Jang,M., Pezzuto,J.M. and Dannenberg,A.J. (1998) Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem., 273, 21875–21882.
  32. Martinez,J. and Moreno,J.J. (2000) Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochem. Pharmacol., 59, 865–870.
  33. Stewart,J.R., Christman,K.L. and O'Brian,C.A. (2000) Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases. Inhibition of protein kinase d but not protein kinase c isozyme autophosphorylation. Biochem. Pharmacol., 60, 1355–1359.
  34. Jang,M. and Pezzuto,J.M. (1999) Cancer chemopreventive activity of resveratrol. Drugs Exp. Clin. Res., 25, 65–77.
  35. Prochaska,H.J. and Santamaria,A.B. (1988) Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal. Biochem., 169, 328–336.
  36. Nielsen,M., Ruch,R.J. and Vang,O. (2000) Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication. Biochem. Biophys. Res. Commun., 275, 804–809.
  37. Trosko,J.E. and Ruch,R.J. (1998) Cell–cell communication in carcinogenesis. Front. Biosci., 3, D208–D236.
  38. Jadeski,L.C., Hum,K.O., Chakraborty,C. and Lala,P.K. (2000) Nitric oxide promotes murine mammary tumour growth and metastasis by stimulating tumour cell migration, invasiveness and angiogenesis. Int. J. Cancer, 86, 30–39.
  39. Yagihashi,N., Kasajima,H., Sugai,S., Matsumoto,K., Ebina,Y., Morita,T., Murakami,T. and Yagihashi,S. (2000) Increased in situ expression of nitric oxide synthase in human colorectal cancer. Virchows Arch., 436, 109–114.
  40. Thomsen,L.L., Lawton,F.G., Knowles,R.G., Beesley,J.E., Riveros-Moreno,V. and Moncada,S. (1994) Nitric oxide synthase activity in human gynecological cancer. Cancer Res., 54, 1352–1354.
  41. Tsai,S.H., Lin-Shiau,S.Y. and Lin,J.K. (1999) Suppression of nitric oxide synthase and the down-regulation of the activation of NFB in macrophages by resveratrol. Br. J. Pharmacol., 126, 673–680.
  42. Huang,S., DeGuzman,A., Bucana,C.D. and Fidler,I.J. (2000) Nuclear factor-B activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice. Clin. Cancer Res., 6, 2573–2581.
  43. Manna,S.K., Mukhopadhyay,A. and Aggarwal,B.B. (2000) Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J. Immunol., 164, 6509–6519.
  44. Wadsworth,T.L. and Koop,D.R. (1999) Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. Biochem. Pharmacol., 57, 941–949.
  45. Kawada,N., Seki,S., Inoue,M. and Kuroki,T. (1998) Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology, 27, 1265–1274.
  46. Matsuda,H., Kageura,T., Morikawa,T., Toguchida,I., Harima,S. and Yoshikawa,M. (2000) Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages. Bioorg. Med. Chem. Lett., 10, 323–327.
  47. Shamon,L.A., Chen,C., Mehta,R.G., Steele,V., Moon,R.C. and Pezzuto,J.M. (1994) A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity. Anticancer Res., 14, 1775–1778.
  48. Mehta,R.G. and Moon,R.C. (1991) Characterization of effective chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol. Anticancer Res., 11, 593–596.
  49. Lee,S.K., Mbwambo,Z.H., Chung,H., Luyengi,L., Gamez,E.J., Mehta,R.G., Kinghorn,A.D. and Pezzuto,J.M. (1998) Evaluation of the antioxidant potential of natural products. Comb. Chem. High Throughput. Screen., 1, 35–46.
  50. Ciolino,H.P., Daschner,P.J. and Yeh,G.C. (1998) Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res., 58, 5707–5712.
  51. Ciolino,H.P. and Yeh,G.C. (1999) Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol. Pharmacol., 56, 760–767.
  52. Casper,R.F., Quesne,M., Rogers,I.M., Shirota,T., Jolivet,A., Milgrom,E. and Savouret,J.F. (1999) Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity. Mol. Pharmacol., 56, 784–790.
  53. Singh,S.U., Casper,R.F., Fritz,P.C., Sukhu,B., Ganss,B., Girard,J.B., Savouret,J.F. and Tenenbaum,H.C. (2000) Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol. J. Endocrinol., 167, 183–195.[Abstract]
  54. Chun,Y.J., Kim,M.Y. and Guengerich,F.P. (1999) Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochem. Biophys. Res. Commun., 262, 20–24.
  55. Hecht,S.S., Kenney,P.M., Wang,M., Trushin,N., Agarwal,S., Rao,A.V. and Upadhyaya,P. (1999) Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo(a)pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Lett., 137, 123–130.
  56. Sharma,S., Stutzman,J.D., Kelloff,G.J. and Steele,V.E. (1994) Screening of potential chemopreventive agents using biochemical markers of carcinogenesis. Cancer Res., 54, 5848–5855.
  57. Damianaki,A., Bakogeorgou,E., Kampa,M., Notas,G., Hatzoglou,A., Panagiotou,S., Gemetzi,C., Kouroumalis,E., Martin,P.M. and Castanas,E. (2000) Potent inhibitory action of red wine polyphenols on human breast cancer cells. J. Cell Biochem., 78, 429–441.
  58. Huang,C., Ma,W.Y., Goranson,A. and Dong,Z. (1999) Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis, 20, 237–242.
  59. Waffo,T.P., Fauconneau,B., Deffieux,G., Huguet,F., Vercauteren,J. and Merillon,J.M. (1998) Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from Vitis vinifera cell cultures. J. Nat. Prod., 61, 655–657.
  60. Zini,R., Morin,C., Bertelli,A., Bertelli,A.A. and Tillement,J.P. (1999) Effects of resveratrol on the rat brain respiratory chain. Drugs Exp. Clin. Res., 25, 87–97.
  61. Zou,J.G., Huang,Y.Z., Chen,Q., Wei,E.H., Hsieh,T.C. and Wu,J.M. (1999) Resveratrol inhibits copper ion-induced and azo compound-initiated oxidative modification of human low density lipoprotein. Biochem. Mol. Biol. Int., 47, 1089–1096.
  62. Fukuhara,K. and Miyata,N. (1998) Resveratrol as a new type of DNA-cleaving agent. Bioorg. Med. Chem. Lett., 8, 3187–3192.
  63. Ahmad,A., Farhan,A.S., Singh,S. and Hadi,S.M. (2000) DNA breakage by resveratrol and Cu(II): reaction mechanism and bacteriophage inactivation. Cancer Lett., 154, 29–37.
  64. Miura,T., Muraoka,S., Ikeda,N., Watanabe,M. and Fujimoto,Y. (2000) Antioxidative and prooxidative action of stilbene derivatives (In Process Citation). Pharmacol. Toxicol., 86, 203–208.
  65. Cadenas,S. and Barja,G. (1999) Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3. Free Radic. Biol. Med., 26, 1531–1537.
  66. Fontecave,M., Lepoivre,M., Elleingand,E., Gerez,C. and Guittet,O. (1998) Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Lett., 421, 277–279.
  67. Sun,N.J., Woo,S.H., Cassady,J.M. and Snapka,R.M. (1998) DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J. Nat. Prod., 61, 362–366.
  68. Schneider,Y., Vincent,F., Duranton,B., Badolo,L., Gosse,F., Bergmann,C., Seiler,N. and Raul,F. (2000) Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett., 158, 85–91.
  69. Elattar,T.M. and Virji,A.S. (1999) The effect of red wine and its components on growth and proliferation of human oral squamous carcinoma cells. Anticancer Res., 19, 5407–5414.
  70. Surh,Y.J., Hurh,Y.J., Kang,J.Y., Lee,E., Kong,G. and Lee,S.J. (1999) Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett., 140, 1–10.
  71. Babich,H., Reisbaum,A.G. and Zuckerbraun,H.L. (2000) In vitro response of human gingival epithelial S-G cells to resveratrol. Toxicol. Lett., 114, 143–153.
  72. Moreno,J.J. (2000) Resveratrol modulates arachidonic acid release, prostaglandin synthesis, and 3T6 fibroblast growth. J. Pharmacol. Exp. Ther., 294, 333–338.
  73. Clement,M.V., Hirpara,J.L., Chawdhury,S.H. and Pervaiz,S. (1998) Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood, 92, 996–1002.
  74. Holmes-McNary,M. and Baldwin,A.S.,Jr (2000) Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IB kinase. Cancer Res., 60, 3477–3483.
  75. Ragione,F.D., Cucciolla,V., Borriello,A., Pietra,V.D., Racioppi,L., Soldati,G., Manna,C., Galletti,P. and Zappia,V. (1998) Resveratrol arrests the cell division cycle at S/G2 phase transition. Biochem. Biophys. Res. Commun., 250, 53–58.
  76. Suh,N., Luyengi,L., Fong,H.H., Kinghorn,A.D. and Pezzuto,J.M. (1995) Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model. Anticancer Res., 15, 233–239.
  77. Hsieh,T.C., Juan,G., Darzynkiewicz,Z. and Wu,J.M. (1999) Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2. Cancer Res., 59, 2596–2601.
  78. Tsan,M.F., White,J.E., Maheshwari,J.G., Bremner,T.A. and Sacco,J. (2000) Resveratrol induces Fas signalling-independent apoptosis in THP-1 human monocytic leukaemia cells. Br. J. Haematol., 109, 405–412.
  79. Carbo,N., Costelli,P., Baccino,F.M., Lopez-Soriano,F.J. and Argiles,J.M. (1999) Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model. Biochem. Biophys. Res. Commun., 254, 739–743.
  80. Tessitore,L., Davit,A., Sarotto,I. and Caderni,G. (2000) Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21CIP expression. Carcinogenesis, 21, 1619–1622.
  81. Gautam,S.C., Xu,Y.X., Dumaguin,M., Janakiraman,N. and Chapman,R.A. (2000) Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging. Bone Marrow Transplant., 25, 639–645.
  82. Hsieh,T.C., Burfeind,P., Laud,K., Backer,J.M., Traganos,F., Darzynkiewicz,Z. and Wu,J.M. (1999) Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials. Int. J. Oncol., 15, 245–252.
  83. MacCarrone,M., Lorenzon,T., Guerrieri,P. and Agro,A.F. (1999) Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity. Eur. J. Biochem., 265, 27–34.
  84. MacCarrone,M., Nieuwenhuizen,W.E., Dullens,H.F., Catani,M.V., Melino,G., Veldink,G.A., Vliegenthart,J.F. and Finazzo,A.A. (1996) Membrane modifications in human erythroleukemia K562 cells during induction of programmed cell death by transforming growth factor ß1 or cisplatin. Eur. J. Biochem., 241, 297–302.
  85. Lu,R. and Serrero,G. (1999) Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J. Cell Physiol., 179, 297–304.
  86. Basly,J.P., Marre-Fournier,F., Le Bail,J.C., Habrioux,G. and Chulia,A.J. (2000) Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol. Life Sci., 66, 769–777.
  87. Mgbonyebi,O.P., Russo,J. and Russo,I.H. (1998) Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int. J. Oncol., 12, 865–869.
  88. Ashby,J., Tinwell,H., Pennie,W., Brooks,A.N., Lefevre,P.A., Beresford,N. and Sumpter,J.P. (1999) Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects. J. Appl. Toxicol., 19, 39–45.
  89. Slater,I., Odum,J. and Ashby,J. (1999) Resveratrol and red wine consumption. Hum. Exp. Toxicol., 18, 625–626.[Free Full Text] Turner,R.T., Evans,G.L., Zhang,M., Maran,A. and Sibonga,J.D. (1999) Is resveratrol an estrogen agonist in growing rats? Endocrinology, 140, 50–54.
  90. Mizutani,K., Ikeda,K., Kawai,Y. and Yamori,Y. (2000) Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats. J. Nutr. Sci. Vitaminol. (Tokyo), 46, 78–83.
  91. Hsieh,T.C. and Wu,J.M. (1999) Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines. Exp. Cell Res., 249, 109–115.
  92. Mitchell,S.H., Zhu,W. and Young,C.Y. (1999) Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Cancer Res., 59, 5892–5895.
  93. Hsieh,T.C. and Wu,J.M. (2000) Grape-derived chemopreventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by an androgen receptor (AR)-independent mechanism. Anticancer Res., 20, 225–228.
  94. Ulsperger,E., Hamilton,G., Raderer,M., Baumgartner,G., Hejna,M., Hoffmann,O. and Mallinger,R. (1999) Resveratrol pretreatment desensitizes AHTO-7 human osteoblasts to growth stimulation in response to carcinoma cell supernatants. Int. J. Oncol., 15, 955–959.
  95. McMurtey,K.D. (1996) Resveratrol in wine. In Watkins,T.R. (ed.) Wine: Nutritional and Therapeutic Benefits. Am. Chem. Soc.
  96. Bertelli,A.A., Giovannini,L., Stradi,R., Urien,S., Tillement,J.P. and Bertelli,A. (1998) Evaluation of kinetic parameters of natural phytoalexin in resveratrol orally administered in wine to rats. Drugs Exp. Clin. Res., 24, 51–55.
  97. Bertelli,A.A., Giovannini,L., Stradi,R., Bertelli,A. and Tillement,J.P. (1996) Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Int. J. Tissue React., 18, 67–71.
  98. Bertelli,A., Bertelli,A.A., Gozzini,A. and Giovannini,L. (1998) Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp. Clin. Res., 24, 133–138.
  99. Kuhnle,G., Spencer,J.P., Chowrimootoo,G., Schroeter,H., Debnam,E.S., Srai,S.K., Rice-Evans,C. and Hahn,U. (2000) Resveratrol is absorbed in the small intestine as resveratrol glucuronide. Biochem. Biophys. Res. Commun., 272, 212–217.
  100. Andlauer,W., Kolb,J., Siebert,K. and Furst,P. (2000) Assessment of resveratrol bioavailability in the perfused small intestine of the rat. Drugs Exp. Clin. Res., 26, 47–55.
  101. Teel,R.W. and Huynh,H. (1998) Modulation by phytochemicals of cytochrome P450-linked enzyme activity. Cancer Lett., 133, 135–141.

Decreased platelet aggregation and resveratrol resveratrol research

  1. Yang YM, Wang XX, Chen JZ, Wang SJ, Hu H, Wang HQ., Resveratrol attenuates adenosine diphosphate-induced platelet activation by reducing protein kinase C activity., Am J Chin Med. 2008;36(3):603-13.
  2. Yang YM, Chen JZ, Wang XX, Wang SJ, Hu H, Wang HQ., Resveratrol attenuates thromboxane A2 receptor agonist-induced platelet activation by reducing phospholipase C activity., Eur J Pharmacol. 2008 Mar 31;583(1):148-55.
  3. Yang YM, Wang XX, Wang SJ, Wang HQ, Chen JZ., [Suppressive effect in vitro of resveratrol on ADP induced human platelet aggregation and its active mechanism] Yao Xue Xue Bao. 2008 Apr;43(4):356-60. [Chinese]
  4. Olas B, Wachowicz B, Tomczak A, Erler J, Stochmal A, Oleszek W., Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro., Platelets. 2008 Feb;19(1):70-7.
  5. Koutsas C, Sarigiannis Y, Stavropoulos G, Liakopoulou-Kyriakides M., Conjugation of resveratrol with RGD and KGD derivatives., Protein Pept Lett. 2007;14(10):1014-20.
  6. de la Lastra CA, Villegas I., Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications., Biochem Soc Trans. 2007 Nov;35(Pt 5):1156-60.
  7. Saiko P, Szakmary A, Jaeger W, Szekeres T., Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?, Mutat Res. 2008 Jan-Feb;658(1-2):68-94. Epub 2007 Aug 17.
  8. Shen MY, Hsiao G, Liu CL, Fong TH, Lin KH, Chou DS, Sheu JR., Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP. Br J Haematol. 2007 Nov;139(3):475-85.
  9. Olas B, Saluk-Juszczak J, Wachowicz B., D-glucaro 1,4-lactone and resveratrol as antioxidants in blood platelets., Cell Biol Toxicol. 2008 Apr;24(2):189-99.
  10. Chen YJ, Wang JS, Chow SE., Resveratrol protects vascular endothelial cell from ox-LDL-induced reduction in antithrombogenic activity., Chin J Physiol. 2007 Feb 28;50(1):22-8. Erratum in: Chin J Physiol. 2007 Apr 30;50(2):98.
  11. Wu CC, Wu CI, Wang WY, Wu YC., Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins., Planta Med. 2007 May;73(5):439-43.
  12. Opie LH, Lecour S., The red wine hypothesis: from concepts to protective signalling molecules., Eur Heart J. 2007 Jul;28(14):1683-93.
  13. de Lange DW, Verhoef S, Gorter G, Kraaijenhagen RJ, van de Wiel A, Akkerman JW., Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox., Alcohol Clin Exp Res. 2007 Aug;31(8):1308-14.
  14. Saeed SA, Connor JD, Imran, Quadri J, Tasneem S, Ahmed S, Mesaik MA, Choudhary MI., Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation., Pharmacol Rep. 2007 Mar-Apr;59(2):238-43.
  15. Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, Kim AL., Resveratrol: a review of preclinical studies for human cancer prevention., Toxicol Appl Pharmacol. 2007 Nov 1;224(3):274-83.
  16. Providęncia R., Cardiovascular protection from alcoholic drinks: scientific basis of the French Paradox., Rev Port Cardiol. 2006 Nov;25(11):1043-58.
  17. Fragopoulou E, Nomikos T, Karantonis HC, Apostolakis C, Pliakis E, Samiotaki M, Panayotou G, Antonopoulou S., Biological activity of acetylated phenolic compounds., J Agric Food Chem. 2007 Jan 10;55(1):80-9.
  18. Csiszar A, Smith K, Labinskyy N, Orosz Z, Rivera A, Ungvari Z., Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1694-9.
  19. Stef G, Csiszar A, Lerea K, Ungvari Z, Veress G., Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance., J Cardiovasc Pharmacol. 2006 Aug;48(2):1-5.
  20. Olas B, Nowak P, Ponczek M, Wachowicz B., Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets., Gen Physiol Biophys. 2006 Jun;25(2):215-22.
  21. Zbikowska HM, Olas B, Wachowicz B, Krajewski T., Response of blood platelets to resveratrol., Platelets. 1999 Jul;10(4):247-52.
  22. Feng L, Jin J, Zhang LF, Yan T, Tao WY., Analysis of the resveratrol-binding protein using phage-displayed random peptide library., Acta Biochim Biophys Sin (Shanghai). 2006 May;38(5):342-8.
  23. Vilar S, Quezada E, Santana L, Uriarte E, Yánez M, Fraiz N, Alcaide C, Cano E, Orallo F., Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids., Bioorg Med Chem Lett. 2006 Jan 15;16(2):257-61.
  24. Wirleitner B, Schroecksnadel K, Winkler C, Schennach H, Fuchs D., Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro., Immunol Lett. 2005 Sep 15;100(2):159-63.
  25. Mousa SS, Mousa SS, Mousa SA., Effect of resveratrol on angiogenesis and platelet/fibrin-accelerated tumor growth in the chick chorioallantoic membrane model., Nutr Cancer. 2005;52(1):59-65.
  26. Olas B, Wachowicz B, Holmsen H, Fukami MH., Resveratrol inhibits polyphosphoinositide metabolism in activated platelets., Biochim Biophys Acta. 2005 Aug 15;1714(2):125-33.
  27. Olas B, Wachowicz B., Resveratrol, a phenolic antioxidant with effects on blood platelet functions., Platelets. 2005 Aug;16(5):251-60.
  28. Delmas D, Jannin B, Latruffe N., Resveratrol: preventing properties against vascular alterations and ageing., Mol Nutr Food Res. 2005 May;49(5):377-95.
  29. Ulrich S, Wolter F, Stein JM., Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis., Mol Nutr Food Res. 2005 May;49(5):452-61.
  30. Huang YL, Tsai WJ, Shen CC, Chen CC., Resveratrol derivatives from the roots of Vitis thunbergii., J Nat Prod. 2005 Feb;68(2):217-20.
  31. Olas B, Wachowicz B, Stochmal A, Oleszek W., Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. bark., Nutrition. 2005 Feb;21(2):199-206.
  32. Wolter F, Ulrich S, Stein J., Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in colorectal cancer: key role of polyamines?, J Nutr. 2004 Dec;134(12):3219-22.
  33. Szewczuk LM, Penning TM., Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study., J Nat Prod. 2004 Nov;67(11):1777-82.
  34. Dong HH, Ren HL., New progression in the study of protective properties of resveratrol in anticardiovascular disease., Bratisl Lek Listy. 2004;105(5-6):225-9.
  35. Bradamante S, Barenghi L, Villa A., Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.
  36. Hao HD, He LR., Mechanisms of cardiovascular protection by resveratrol., J Med Food. 2004 Fall;7(3):290-8.
  37. Kaneider NC, Mosheimer B, Reinisch N, Patsch JR, Wiedermann CJ., Inhibition of thrombin-induced signaling by resveratrol and quercetin: effects on adenosine nucleotide metabolism in endothelial cells and platelet-neutrophil interactions., Thromb Res. 2004;114(3):185-94.
  38. Fukao H, Ijiri Y, Miura M, Hashimoto M, Yamashita T, Fukunaga C, Oiwa K, Kawai Y, Suwa M, Yamamoto J., Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice., Blood Coagul Fibrinolysis. 2004 Sep;15(6):441-6.
  39. Kollár P, Hotolová H., [Biological effects of resveratrol and other constituents of wine] Ceska Slov Farm. 2003 Nov;52(6):272-81. [Czech.]
  40. Schriever C, Pendland SL, Mahady GB., Red wine, resveratrol, Chlamydia pneumoniae and the French connection., Atherosclerosis. 2003 Dec;171(2):379-80.
  41. Chen LN, Zang WJ, Tang YH., [Progress in cardiovascular protective effects of resveratrol], Sheng Li Ke Xue Jin Zhan. 2003 Jul;34(3):272-4. [Chinese]
  42. Granados-Soto V., Pleiotropic effects of resveratrol., Drug News Perspect. 2003 Jun;16(5):299-307.
  43. Togna GI, Togna AR, Franconi M, Marra C, Guiso M., Olive oil isochromans inhibit human platelet reactivity., J Nutr. 2003 Aug;133(8):2532-6.
  44. Olas B, Wachowicz B, Stochmal A, Oleszek W., Inhibition of oxidative stress in blood platelets by different phenolics from Yucca schidigera Roezl. bark., Nutrition. 2003 Jul-Aug;19(7-8):633-40.
  45. Kaldas MI, Walle UK, Walle T., Resveratrol transport and metabolism by human intestinal Caco-2 cells., J Pharm Pharmacol. 2003 Mar;55(3):307-12.
  46. Olas B, Wachowicz B, Saluk-Juszczak J, Zielinski T., Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin., Thromb Res. 2002 Aug 15;107(3-4):141-5. Suttnar J, Másová L, Scheiner T, Sorelová V, Dyr JE., [Role of free radicals in blood platelet activation], Cas Lek Cesk. 2002 Sep 22;141 Suppl:47-9. [Czech]
  47. Olas B, Wachowicz B, Stochmal A, Oleszek W., Anti-platelet effects of different phenolic compounds from Yucca schidigera Roezl. bark., Platelets. 2002 May;13(3):167-73.
  48. Sinha K, Chaudhary G, Gupta YK., Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats., Life Sci. 2002 Jun 28;71(6):655-65.
  49. Ignatowicz E, Baer-Dubowska W., Resveratrol, a natural chemopreventive agent against degenerative diseases., Pol J Pharmacol. 2001Nov-Dec;53(6):557-69.
  50. Wang Z, Zou J, Huang Y, Cao K, Xu Y, Wu JM., Effect of resveratrol on platelet aggregation in vivo and in vitro., Chin Med J (Engl). 2002 Mar;115(3):378-80.
  51. El-Mowafy AM., Resveratrol activates membrane-bound guanylyl cyclase in coronary arterial smooth muscle: a novel signaling mechanism in support of coronary protection., Biochem Biophys Res Commun. 2002 Mar 15;291(5):1218-24.
  52. Bhat KPL, Kosmeder JW 2nd, Pezzuto JM., Biological effects of resveratrol. Antioxid Redox Signal. 2001 Dec;3(6):1041-64.
  53. Wang Z, Huang Y, Zou J, Cao K, Xu Y, Wu JM., Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro., Int J Mol Med. 2002 Jan;9(1):77-9.
  54. Huang SS, Tsai MC, Chih CL, Hung LM, Tsai SK., Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia., Life Sci. 2001 Jul 20;69(9):1057-65.
  55. Pervaiz S., Resveratrol--from the bottle to the bedside?, Leuk Lymphoma. 2001 Feb;40(5-6):491-8.
  56. Stojanovic S, Sprinz H, Brede O., Efficiency and mechanism of the antioxidant action of trans-resveratrol and its analogues in the radical liposome oxidation., Arch Biochem Biophys. 2001 Jul 1;391(1):79-89.
  57. Wu JM, Wang ZR, Hsieh TC, Bruder JL, Zou JG, Huang YZ., Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine., Int J Mol Med. 2001 Jul;8(1):3-17.
  58. Russo P, Tedesco I, Russo M, Russo GL, Venezia A, Cicala C., Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation., Nutr Metab Cardiovasc Dis. 2001 Feb;11(1):25-9.
  59. Olas B, Wachowicz B, Szewczuk J, Saluk-Juszczak J, Kaca W., The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin., Microbios. 2001;105(410):7-13.
  60. Ibern-Gómez M, Roig-Pérez S, Lamuela-Raventós RM, de la Torre-Boronat MC., Resveratrol and piceid levels in natural and blended peanut butters., J Agric Food Chem. 2000 Dec;48(12):6352-4.
  61. Jonsson KO, Hedin HL, Fowler CJ., Investigation into the rapid effects of 17 beta-estradiol and neuroactive steroids upon beta-amyloid(25-35)-induced activation of phosphoinositide-specific phospholipase C in human platelets., Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):615-20.
  62. Romero-Pérez AI, Lamuela-Raventós RM, Andrés-Lacueva C, de La Torre-Boronat MC., Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content., J Agric Food Chem. 2001 Jan;49(1):210-5.
  63. Aburjai TA., Anti-platelet stilbenes from aerial parts of Rheum palaestinum., Phytochemistry. 2000 Nov;55(5):407-10.
  64. Kirk RI, Deitch JA, Wu JM, Lerea KM., Resveratrol decreases early signaling events in washed platelets but has little effect on platelet in whole blood., Blood Cells Mol Dis. 2000 Apr;26(2):144-50.
  65. Olas B, Zbikowska HM, Wachowicz B, Krajewski T, Buczynski A, Magnuszewska A., Inhibitory effect of resveratrol on free radical generation in blood platelets., Acta Biochim Pol. 1999;46(4):961-6.
  66. Zhu Y, Huang T, Cregor M, Long H, Kissinger CB, Kissinger PT., Liquid chromatography with multichannel electrochemical detection for the determination of trans-resveratrol in rat blood utilizing an automated blood sampling device., J Chromatogr B Biomed Sci Appl. 2000 Mar 31;740(1):129-33.
  67. Naderali EK, Doyle PJ, Williams G., Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs., Clin Sci (Lond). 2000 May;98(5):537-43.
  68. Sanders TH, McMichael RW Jr, Hendrix KW., Occurrence of resveratrol in edible peanuts., J Agric Food Chem. 2000 Apr;48(4):1243-6.
  69. Fragopoulou E, Nomikos T, Antonopoulou S, Mitsopoulou CA, Demopoulos CA., Separation of biologically active lipids from red wine., J Agric Food Chem. 2000 Apr;48(4):1234-8.
  70. Paul B, Masih I, Deopujari J, Charpentier C., Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India., J Ethnopharmacol. 1999 Dec 15;68(1-3):71-6.
  71. Romero-Pérez AI, Ibern-Gómez M, Lamuela-Raventós RM, de La Torre-Boronat MC., Piceid, the major resveratrol derivative in grape juices., J Agric Food Chem. 1999 Apr;47(4):1533-6.
  72. Dobrydneva Y, Williams RL, Blackmore PF., Trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets., Br J Pharmacol. 1999 Sep;128(1):149-57.
  73. Das DK, Sato M, Ray PS, Maulik G, Engelman RM, Bertelli AA, Bertelli A., Cardioprotection of red wine: role of polyphenolic antioxidants., Drugs Exp Clin Res. 1999;25(2-3):115-20.
  74. Blardi P, De Lalla A, Volpi L, Di Perri T., Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man., Drugs Exp Clin Res. 1999;25(2-3):105-10.
  75. Bavaresco L, Fregoni C, Cantů E, Trevisan M., Stilbene compounds: from the grapevine to wine., Drugs Exp Clin Res. 1999;25(2-3):57-63.
  76. Bertelli AA., Recent progress in research on wine and its components and their favorable effects on health., Drugs Exp Clin Res. 1999;25(2-3):51-2.
  77. Ferrero ME, Bertelli AA, Pellegatta F, Fulgenzi A, Corsi MM, Bertelli A., Phytoalexin resveratrol (3-4'-5-trihydroxystilbene) modulates granulocyte and monocyte endothelial adhesion., Transplant Proc. 1998 Dec;30(8):4191-3.
  78. Bertelli A, Bertelli AA, Gozzini A, Giovannini L., Plasma and tissue resveratrol concentrations and pharmacological activity., Drugs Exp Clin Res. 1998;24(3):133-8.
  79. Cichewicz RH, Kouzi SA., Biotransformation of resveratrol to piceid by Bacillus cereus., J Nat Prod. 1998 Oct;61(10):1313-4.
  80. Kopp P., Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?, Eur J Endocrinol. 1998 Jun;138(6):619-20.
  81. Constant J., Alcohol, ischemic heart disease, and the French paradox., Coron Artery Dis. 1997 Oct;8(10):645-9.
  82. Blache D, Rustan I, Durand P, Lesgards G, Loreau N., Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations., J Chromatogr B Biomed Sci Appl. 1997 Nov 21;702(1-2):103-10.
  83. Orsini F, Pelizzoni F, Verotta L, Aburjai T, Rogers CB., Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-beta-D-glucopyranoside and related compounds., J Nat Prod. 1997 Nov;60(11):1082-7.
  84. Orsini F, Pelizzoni F, Bellini B, Miglierini G., Synthesis of biologically active polyphenolic glycosides (combretastatin and resveratrol series)., Carbohydr Res. 1997 Jun 20;301(3-4):95-109.
  85. Soleas GJ, Diamandis EP, Goldberg DM., Resveratrol: a molecule whose time has come? And gone?, Clin Biochem. 1997 Mar;30(2):91-113.
  86. Soleas GJ, Diamandis EP, Goldberg DM., Wine as a biological fluid: history, production, and role in disease prevention., J Clin Lab Anal. 1997;11(5):287-313.
  87. Rotondo S, Rotilio D, Cerletti C, de Gaetano G., Red wine, aspirin and platelet function., Thromb Haemost. 1996 Nov;76(5):818-9.
  88. Goldberg DM, Tsang E, Karumanchiri A, Diamandis E, Soleas G, Ng E., Method to assay the concentrations of phenolic constituents of biological interest in wines., Anal Chem. 1996 May 15;68(10):1688-94.
  89. Pace-Asciak CR, Rounova O, Hahn SE, Diamandis EP, Goldberg DM., Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta. 1996 Mar 15;246(1-2):163-82.
  90. Bertelli AA, Giovannini L, Stradi R, Bertelli A, Tillement JP., Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats., Int J Tissue React. 1996;18(2-3):67-71.
  91. Bertelli AA, Giovannini L, Bernini W, Migliori M, Fregoni M, Bavaresco L, Bertelli A., Antiplatelet activity of cis-resveratrol., Drugs Exp Clin Res. 1996;22(2):61-3.
  92. Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL., Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits., Life Sci. 1996;59(1):PL15-21.
  93. Goldberg DM., More on antioxidant activity of resveratrol in red wine., Clin Chem. 1996 Jan;42(1):113-4.
  94. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM., The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease., Clin Chim Acta. 1995 Mar 31;235(2):207-19.
  95. Bertelli AA, Giovannini L, Giannessi D, Migliori M, Bernini W, Fregoni M, Bertelli A., Antiplatelet activity of synthetic and natural resveratrol in red wine., Int J Tissue React. 1995;17(1):1-3.
  96. Chung MI, Teng CM, Cheng KL, Ko FN, Lin CN., An antiplatelet principle of Veratrum formosanum., Planta Med. 1992 Jun;58(3):274-6.

Fight and retard aging resveratrol research

  1. Oliva J, French BA, Li J, Bardag-Gorce F, Fu P, French SW., Sirt1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol., Exp Mol Pathol. 2008 Aug 28.
  2. Orallo F., Trans-resveratrol: a magical elixir of eternal youth?, Curr Med Chem. 2008;15(19):1887-98.
  3. Rayalam S, Yang JY, Ambati S, Della-Fera MA, Baile CA., Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes., Phytother Res. 2008 Aug 7.
  4. Markus MA, Morris BJ., Resveratrol in prevention and treatment of common clinical conditions of aging., Clin Interv Aging. 2008;3(2):331-9.
  5. Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Wang WJ, Song X, Chu WM, Kouttab N, Xu A, Wan Y., SIRT1 confers protection against UVB- and H(2)O(2)-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes., J Cell Mol Med. 2008 Aug 4.
  6. López-Lluch G, Irusta PM, Navas P, de Cabo R., Mitochondrial biogenesis and healthy aging. Exp Gerontol. 2008 Sep;43(9):813-9.
  7. Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R., Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart., Exp Gerontol. 2008 Sep;43(9):859-66.
  8. Mattson MP, Son TG, Camandola S., Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals., Dose Response. 2007 Aug 6;5(3):174-86.
  9. Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E., Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity., Neurochem Res. 2008 Jul 16.
  10. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R., Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span., Cell Metab. 2008 Aug;8(2):157-68.
  11. Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA., A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice., PLoS ONE. 2008 Jun 4;3(6):e2264.
  12. Chen CY, Blumberg JB., Phytochemical composition of nuts., Asia Pac J Clin Nutr. 2008;17 Suppl 1:329-32.
  13. Deng JY, Hsieh PS, Huang JP, Lu LS, Hung LM., Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways., Diabetes. 2008 Jul;57(7):1814-23.
  14. Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R, Ballabh P, Ungvari Z., Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations., Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35.
  15. Guarente L., Sirtuins in aging and disease., Cold Spring Harb Symp Quant Biol. 2007;72:483-8.
  16. Rossi L, Mazzitelli S, Arciello M, Capo CR, Rotilio G., Benefits from Dietary Polyphenols for Brain Aging and Alzheimer's Disease., Neurochem Res. 2008 Apr 16.
  17. Harikumar KB, Aggarwal BB., Resveratrol: a multitargeted agent for age-associated chronic diseases., Cell Cycle. 2008 Apr;7(8):1020-35.
  18. Huang J, Gan Q, Han L, Li J, Zhang H, Sun Y, Zhang Z, Tong T., SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts., PLoS ONE. 2008 Mar 5;3(3):e1710.
  19. Baxter RA., Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation., J Cosmet Dermatol. 2008 Mar;7(1):2-7.
  20. Pallŕs M, Verdaguer E, Tajes M, Gutierrez-Cuesta J, Camins A., Modulation of sirtuins: new targets for antiageing., Recent Patents CNS Drug Discov. 2008 Jan;3(1):61-9.
  21. Hsu CP, Odewale I, Alcendor RR, Sadoshima J., Sirt1 protects the heart from aging and stress. Biol Chem. 2008 Mar;389(3):221-31.
  22. Engel N, Mahlknecht U., Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation., Int J Mol Med. 2008 Feb;21(2):223-32.
  23. Bickenbach KA, Veerapong J, Shao MY, Mauceri HJ, Posner MC, Kron SJ, Weichselbaum RR., Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy., Cancer Gene Ther. 2008 Mar;15(3):133-9.
  24. Swindell WR., Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues., Mech Ageing Dev. 2008 Mar;129(3):138-53.
  25. Burton DG, Sheerin AN, Ostler EL, Smith K, Giles PJ, Lowe J, Rhys-Williams W, Kipling DG, Faragher RG., Cyclin D1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cells., Ann N Y Acad Sci. 2007 Nov;1119:20-31.
  26. Baumann LS., Less-known botanical cosmeceuticals., Dermatol Ther. 2007 Sep-Oct;20(5):330-42.
  27. Gambuti A, Strollo D, Erbaggio A, Lecce L, Moio L., Effect of winemaking practices on color indexes and selected bioactive phenolics of Aglianico wine., J Food Sci. 2007 Nov;72(9):S623-8.
  28. de la Lastra CA, Villegas I., Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications., Biochem Soc Trans. 2007 Nov;35(Pt 5):1156-60.
  29. Putics A, Végh EM, Csermely P, Soti C., Resveratrol induces the heat-shock response and protects human cells from severe heat stress., Antioxid Redox Signal. 2008 Jan;10(1):65-75.
  30. Rasouri S, Lagouge M, Auwerx J., [SIRT1/PGC-1: a neuroprotective axis?], Med Sci (Paris). 2007 Oct;23(10):840-4. [French]
  31. Mattson MP., Dietary factors, hormesis and health., Ageing Res Rev. 2008 Jan;7(1):43-8. Epub 2007 Sep 1.
  32. Bass TM, Weinkove D, Houthoofd K, Gems D, Partridge L., Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans., Mech Ageing Dev. 2007 Oct;128(10):546-52.
  33. Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE., Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms., Cancer Res. 2007 Sep 1;67(17):8396-405.
  34. Stefani M, Markus MA, Lin RC, Pinese M, Dawes IW, Morris BJ., The effect of resveratrol on a cell model of human aging., Ann N Y Acad Sci. 2007 Oct;1114:407-18.
  35. Cucciolla V, Borriello A, Oliva A, Galletti P, Zappia V, Della Ragione F., Resveratrol: from basic science to the clinic., Cell Cycle. 2007 Oct 15;6(20):2495-510.
  36. Barrera-García VD, Gougeon RD, Di Majo D, De Aguirre C, Voilley A, Chassagne D., Different sorption behaviors for wine polyphenols in contact with oak wood., J Agric Food Chem. 2007 Aug 22;55(17):7021-7.
  37. Kaeberlein M, Kennedy BK., Does resveratrol activate yeast Sir2 in vivo?, Aging Cell. 2007 Aug;6(4):415-6.
  38. Heiss EH, Schilder YD, Dirsch VM., Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells., J Biol Chem. 2007 Sep 14;282(37):26759-66.
  39. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH., SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis., EMBO J. 2007 Jul 11;26(13):3169-79.
  40. Fröjdö S, Cozzone D, Vidal H, Pirola L., Resveratrol is a class IA phosphoinositide 3-kinase inhibitor., Biochem J. 2007 Sep 15;406(3):511-8.
  41. Sedding D, Haendeler J., Do we age on Sirt1 expression?, Circ Res. 2007 May 25;100(10):1396-8.
  42. Gruber J, Tang SY, Halliwell B., Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans., Ann N Y Acad Sci. 2007 Apr;1100:530-42.
  43. Dasgupta B, Milbrandt J., Resveratrol stimulates AMP kinase activity in neurons., Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7217-22.
  44. Ungvari Z, Orosz Z, Labinskyy N, Rivera A, Xiangmin Z, Smith K, Csiszar A., Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries., Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H37-47.
  45. Kallithraka S, Mamalos A, Makris DP., Differentiation of young red wines based on chemometrics of minor polyphenolic constituents., J Agric Food Chem. 2007 May 2;55(9):3233-9.
  46. Bastianetto S, Brouillette J, Quirion R., Neuroprotective effects of natural products: interaction with intracellular kinases, amyloid peptides and a possible role for transthyretin., Neurochem Res. 2007 Oct;32(10):1720-5.
  47. Jefremov V, Zilmer M, Zilmer K, Bogdanovic N, Karelson E., Antioxidative effects of plant polyphenols: from protection of G protein signaling to prevention of age-related pathologies., Ann N Y Acad Sci. 2007 Jan;1095:449-57.
  48. Tang BL, Chua CE., SIRT1 and neuronal diseases., Mol Aspects Med. 2008 Jun;29(3):187-200.
  49. Russo GL., Ins and outs of dietary phytochemicals in cancer chemoprevention., Biochem Pharmacol. 2007 Aug 15;74(4):533-44.
  50. Blagosklonny MV., An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Discov Today. 2007 Mar;12(5-6):218-24.
  51. Austad SN., Vertebrate aging research 2006., Aging Cell. 2007 Apr;6(2):135-8.
  52. Stipp D., Live forever?, Fortune. 2007 Feb 5;155(2):68-70, 72, 74 passim.
  53. Holme AL, Pervaiz S., Resveratrol in cell fate decisions., J Bioenerg Biomembr. 2007 Feb;39(1):59-63.
  54. Labie D, Ferré P., [Cheers !], Med Sci (Paris). 2007 Feb;23(2):122. [French]
  55. Ungvari Z, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson S, Podlutsky A, Csiszar A., Resveratrol increases vascular oxidative stress resistance., Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2417-24.
  56. Chen D, Guarente L., SIR2: a potential target for calorie restriction mimetics., Trends Mol Med. 2007 Feb;13(2):64-71.
  57. Sinclair D, Komaroff AL., Can we slow aging?, Newsweek. 2006 Dec 11;148(24):80, 82, 84.
  58. Koo SH, Montminy M., In vino veritas: a tale of two sirt1s?, Cell. 2006 Dec 15;127(6):1091-3.
  59. Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA., Design and synthesis of compounds that extend yeast replicative lifespan., Aging Cell. 2007 Feb;6(1):35-43. Erratum in: Aging Cell. 2007 Aug;6(4):593. Adams, Jeffrey K [added]; Kisielewski, Anne [added]; Howitz, Konrad T [added]; Zipkin, Robert E [added].
  60. Kaeberlein M, Rabinovitch PS., Medicine: grapes versus gluttony., Nature. 2006 Nov 16;444(7117):280-1.
  61. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA., Resveratrol improves health and survival of mice on a high-calorie diet., Nature. 2006 Nov 16;444(7117):337-42.
  62. Terzibasi E, Valenzano DR, Cellerino A., The short-lived fish Nothobranchius furzeri as a new model system for aging studies., Exp Gerontol. 2007 Jan-Feb;42(1-2):81-9.
  63. Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I., Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging., Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L567-76.
  64. Mattson MP, Cheng A., Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses., Trends Neurosci. 2006 Nov;29(11):632-9.
  65. Yao Y, Tian T, Nan KJ., [Research on resveratrol's mechanism of immunity in anti-aging], Zhong Yao Cai. 2006 May;29(5):464-7. [Chinese]
  66. Csiszar A, Smith K, Labinskyy N, Orosz Z, Rivera A, Ungvari Z., Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1694-9.
  67. Horn TL, Cwik MJ, Morrissey RL, Kapetanovic I, Crowell JA, Booth TD, McCormick DL., Oncogenicity evaluation of resveratrol in p53(+/-) (p53 knockout) mice., Food Chem Toxicol. 2007 Jan;45(1):55-63.
  68. Ramassamy C., Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets., Eur J Pharmacol. 2006 Sep 1;545(1):51-64.
  69. Afaq F, Mukhtar H., Botanical antioxidants in the prevention of photocarcinogenesis and photoaging., Exp Dermatol. 2006 Sep;15(9):678-84.
  70. Collins JJ, Evason K, Kornfeld K., Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans., Exp Gerontol. 2006 Oct;41(10):1032-9.
  71. Spinney L., Gerontology: eat your cake and have it., Nature. 2006 Jun 15;441(7095):807-9.
  72. Anekonda TS., Resveratrol--a boon for treating Alzheimer's disease?, Brain Res Rev. 2006 Sep;52(2):316-26.
  73. Baur JA, Sinclair DA., Therapeutic potential of resveratrol: the in vivo evidence., Nat Rev Drug Discov. 2006 Jun;5(6):493-506.
  74. Valenzano DR, Cellerino A., Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule., Cell Cycle. 2006 May;5(10):1027-32.
  75. Ingram DK, Zhu M, Mamczarz J, Zou S, Lane MA, Roth GS, deCabo R., Calorie restriction mimetics: an emerging research field., Aging Cell. 2006 Apr;5(2):97-108.
  76. Labinskyy N, Csiszar A, Veress G, Stef G, Pacher P, Oroszi G, Wu J, Ungvari Z., Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen., Curr Med Chem. 2006;13(9):989-96.
  77. Sinclair DA, Guarente L., Unlocking the secrets of longevity genes., Sci Am. 2006 Mar;294(3):48-51, 54-7.
  78. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A., Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate., Curr Biol. 2006 Feb 7;16(3):296-300.
  79. Osawa T., [Recent development and future direction of anti-aging therapy by supplements] Nippon Ronen Igakkai Zasshi. 2005 Nov;42(6):587-95. [Japanese]
  80. Tatar M., SIR2 calls upon the ER., Cell Metab. 2005 Nov;2(5):281-2.
  81. Supornsilchai V, Svechnikov K, Seidlova-Wuttke D, Wuttke W, Söder O., Phytoestrogen resveratrol suppresses steroidogenesis by rat adrenocortical cells by inhibiting cytochrome P450 c21-hydroxylase., Horm Res. 2005;64(6):280-6.
  82. Viswanathan M, Kim SK, Berdichevsky A, Guarente L., A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span., Dev Cell. 2005 Nov;9(5):605-15.
  83. Anekonda TS, Reddy PH., Neuronal protection by sirtuins in Alzheimer's disease., J Neurochem. 2006 Jan;96(2):305-13. Epub 2005 Oct 7.
  84. Morris BJ., A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer. J Hypertens. 2005 Jul;23(7):1285-309.
  85. Sinclair DA., Toward a unified theory of caloric restriction and longevity regulation., Mech Ageing Dev. 2005 Sep;126(9):987-1002.
  86. de la Lastra CA, Villegas I., Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications., Mol Nutr Food Res. 2005 May;49(5):405-30.
  87. Delmas D, Jannin B, Latruffe N., Resveratrol: preventing properties against vascular alterations and ageing., Mol Nutr Food Res. 2005 May;49(5):377-95.
  88. Provinciali M, Re F, Donnini A, Orlando F, Bartozzi B, Di Stasio G, Smorlesi A., Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice., Int J Cancer. 2005 May 20;115(1):36-45.
  89. Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK., Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17038-45.
  90. Burzynski SR., Aging: gene silencing or gene activation?, Med Hypotheses. 2005;64(1):201-8.
  91. Jarolim S, Millen J, Heeren G, Laun P, Goldfarb DS, Breitenbach M., A novel assay for replicative lifespan in Saccharomyces cerevisiae., FEMS Yeast Res. 2004 Nov;5(2):169-77.
  92. Bauer JH, Goupil S, Garber GB, Helfand SL., An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster., Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12980-5.
  93. Flurkey K, Currer JM., Pitfalls of animal model systems in ageing research., Best Pract Res Clin Endocrinol Metab. 2004 Sep;18(3):407-21.
  94. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D., Sirtuin activators mimic caloric restriction and delay ageing in metazoans., Nature. 2004 Aug 5;430(7000):686-9.
  95. Leslie M., Resveratrol to the rescue., Sci Aging Knowledge Environ. 2004 Jul 14;2004(28):nf67.
  96. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L., Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma., Nature. 2004 Jun 17;429(6993):771-6.
  97. Horseman RE., Say yes to sirtuin; no to lamp shades., J Calif Dent Assoc. 2004 Feb;32(2):198, 197.
  98. Couzin J., Scientific community. Aging research's family feud., Science. 2004 Feb 27;303(5662):1276-9.
  99. O'Neill B., In Methuselah's Mould., PLoS Biol. 2004 Jan;2(1):E12.
  100. Pocar P, Augustin R, Fischer B., Constitutive expression of CYP1A1 in bovine cumulus oocyte-complexes in vitro: mechanisms and biological implications., Endocrinology. 2004 Apr;145(4):1594-601.
  101. Corder R, Crozier A, Kroon PA., Drinking your health? It's too early to say., Nature. 2003 Nov 13;426(6963):119.
  102. Finkel T., Ageing: a toast to long life., Nature. 2003 Sep 11;425(6954):132-3.
  103. Hall SS., Longevity research. In vino vitalis? Compounds activate life-extending genes., Science. 2003 Aug 29;301(5637):1165.
  104. Bhavnani BR., Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's., J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):473-82.
  105. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA., Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan., Nature. 2003 Sep 11;425(6954):191-6.
  106. Flamini R., Mass spectrometry in grape and wine chemistry. Part I: polyphenols., Mass Spectrom Rev. 2003 Jul-Aug;22(4):218-50.
  107. Boscolo P, del Signore A, Sabbioni E, Di Gioacchino M, Di Giampaolo L, Reale M, Conti P, Paganelli R, Giaccio M., Effects of resveratrol on lymphocyte proliferation and cytokine release., Ann Clin Lab Sci. 2003 Spring;33(2):226-31.
  108. Schwedhelm E, Maas R, Troost R, Böger RH., Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stress., Clin Pharmacokinet. 2003;42(5):437-59.
  109. López-Burillo S, Tan DX, Mayo JC, Sainz RM, Manchester LC, Reiter RJ., Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions., J Pineal Res. 2003 May;34(4):269-77.
  110. Sparrow JR, Vollmer-Snarr HR, Zhou J, Jang YP, Jockusch S, Itagaki Y, Nakanishi K., A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation., J Biol Chem. 2003 May 16;278(20):18207-13.
  111. Pozo-Bayón MA, Hernández MT, Martín-Alvarez PJ, Polo MC., Study of low molecular weight phenolic compounds during the aging of sparkling wines manufactured with red and white grape varieties., J Agric Food Chem. 2003 Mar 26;51(7):2089-95.
  112. Liu C, Russell RM, Wang XD., Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes., J Nutr. 2003 Jan;133(1):173-9.
  113. Bastianetto S, Quirion R., Natural extracts as possible protective agents of brain aging., Neurobiol Aging. 2002 Sep-Oct;23(5):891-97.
  114. Sun AY, Simonyi A, Sun GY., The "French Paradox" and beyond: neuroprotective effects of polyphenols., Free Radic Biol Med. 2002 Feb 15;32(4):314-8.
  115. Igura K, Ohta T, Kuroda Y, Kaji K., Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001 Sep 28;171(1):11-6.
  116. Frankel D, Schipper HM., Cysteamine pretreatment of the astroglial substratum (mitochondrial iron sequestration) enhances PC12 cell vulnerability to oxidative injury., Exp Neurol. 1999 Dec;160(2):376-85.
  117. Sun AY, Chen YM, James-Kracke M, Wixom P, Cheng Y., Ethanol-induced cell death by lipid peroxidation in PC12 cells., Neurochem Res. 1997 Oct;22(10):1187-92.
  118. Pezzuto JM., Grapes and human health: a perspective., J Agric Food Chem. 2008 Aug 27;56(16):6777-84.

Immune boosting effect of resveratrol immune boosting effect of resveratrol

  1. Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ., Potential of resveratrol in anticancer and anti-inflammatory therapy., Nutr Rev. 2008 Aug;66(8):445-54.
  2. Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R., Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart., Exp Gerontol. 2008 Sep;43(9):859-66.
  3. Yang Y, Paik JH, Cho D, Cho JA, Kim CW., Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells., Int Immunopharmacol. 2008 Apr;8(4):542-7.
  4. Clarke JO, Mullin GE., A review of complementary and alternative approaches to immunomodulation., Nutr Clin Pract. 2008 Feb;23(1):49-62.
  5. Pan MH, Gao JH, Lai CS, Wang YJ, Chen WM, Lo CY, Wang M, Dushenkov S, Ho CT., Antitumor activity of 3,5,4'-trimethoxystilbene in COLO 205 cells and xenografts in SCID mice., Mol Carcinog. 2008 Mar;47(3):184-96.
  6. Banerjee T, Duhadaway JB, Gaspari P, Sutanto-Ward E, Munn DH, Mellor AL, Malachowski WP, Prendergast GC, Muller AJ., A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase., Oncogene. 2008 May 1;27(20):2851-7.
  7. Block G, Jensen CD, Norkus EP, Dalvi TB, Wong LG, McManus JF, Hudes ML., Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study., Nutr J. 2007 Oct 24;6:30.
  8. Hsieh SC, Lu CC, Horng YT, Soo PC, Chang YL, Tsai YH, Lin CS, Lai HC., The bacterial metabolite 2,3-butanediol ameliorates endotoxin-induced acute lung injury in rats., Microbes Infect. 2007 Oct;9(12-13):1402-9.
  9. Das S, Das DK., Anti-inflammatory responses of resveratrol., Inflamm Allergy Drug Targets. 2007 Sep;6(3):168-73.
  10. Vetvicka V, Volny T, Saraswat-Ohri S, Vashishta A, Vancikova Z, Vetvickova J., Glucan and resveratrol complex--possible synergistic effects on immune system., Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Jun;151(1):41-6.
  11. Li T, Fan GX, Wang W, Li T, Yuan YK., Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo., Int Immunopharmacol. 2007 Sep;7(9):1221-31.
  12. Salinas I, Rodríguez A, Meseguer J, Esteban MA., Adenosine arrests apoptosis in lymphocytes but not in phagocytes from primary leucocyte cultures of the teleost fish, Sparus aurata L., Dev Comp Immunol. 2007;31(12):1233-41.
  13. Penberthy WT., Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease., Curr Drug Metab. 2007 Apr;8(3):245-66.
  14. Sharma S, Chopra K, Kulkarni SK, Agrewala JN., Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway., Clin Exp Immunol. 2007 Jan;147(1):155-63.
  15. Nam NH., Naturally occurring NF-kappaB inhibitors., Mini Rev Med Chem. 2006 Aug;6(8):945-51.
  16. Rachon D, Rimoldi G, Wuttke W., In vitro effects of genistein and resveratrol on the production of interferon-gamma (IFNgamma) and interleukin-10 (IL-10) by stimulated murine splenocytes., Phytomedicine. 2006 Jun;13(6):419-24.
  17. Bárta I, Smerák P, Polívková Z, Sestáková H, Langová M, Turek B, Bártová J., Current trends and perspectives in nutrition and cancer prevention., Neoplasma. 2006;53(1):19-25.
  18. Tao HY, Wu CF, Zhou Y, Gong WH, Zhang X, Iribarren P, Zhao YQ, Le YY, Wang JM., The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes., Cell Mol Immunol. 2004 Feb;1(1):50-6.
  19. Schroecksnadel K, Winkler C, Wirleitner B, Schennach H, Weiss G, Fuchs D., Anti-inflammatory compound resveratrol suppresses homocysteine formation in stimulated human peripheral blood mononuclear cells in vitro., Clin Chem Lab Med. 2005;43(10):1084-8.
  20. Wirleitner B, Schroecksnadel K, Winkler C, Schennach H, Fuchs D., Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro., Immunol Lett. 2005 Sep 15;100(2):159-63.
  21. Li T, Sheng L, Fan GX, Yuan YK, Li T., [Preliminary study on anti-tumor function of resveratrol and its immunological mechanism], Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2005 Sep;21(5):575-9. [Chinese]
  22. Marier JF, Chen K, Prince P, Scott G, del Castillo JR, Vachon P.,Production of ex vivo lipopolysaccharide-induced tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 is suppressed by trans-resveratrol in a concentration-dependent manner., Can J Vet Res. 2005 Apr;69(2):151-4.
  23. de la Lastra CA, Villegas I., Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications., Mol Nutr Food Res. 2005 May;49(5):405-30.
  24. Kimura Y., New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants., In Vivo. 2005 Jan-Feb;19(1):37-60.
  25. Provinciali M, Re F, Donnini A, Orlando F, Bartozzi B, Di Stasio G, Smorlesi A., Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice., Int J Cancer. 2005 May 20;115(1):36-45.
  26. Wang LX, Heredia A, Song H, Zhang Z, Yu B, Davis C, Redfield R., Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity., J Pharm Sci. 2004 Oct;93(10):2448-57.
  27. Khanduja KL, Bhardwaj A, Kaushik G., Resveratrol inhibits N-nitrosodiethylamine-induced ornithine decarboxylase and cyclooxygenase in mice., J Nutr Sci Vitaminol (Tokyo). 2004 Feb;50(1):61-5.
  28. Yu L, Wu SL, Zhang M, Pan CE., [Effect of resveratrol alone and its combination with cyclosporin A on the immune function of human peripheral blood T lymphocytes], Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003 Nov;19(6):549-51. [Chinese]
  29. Kim GY, Cho H, Ahn SC, Oh YH, Lee CM, Park YM., Resveratrol inhibits phenotypic and functional maturation of murine bone marrow-derived dendritic cells., Int Immunopharmacol. 2004 Feb;4(2):245-53.
  30. Gao X, Deeb D, Media J, Divine G, Jiang H, Chapman RA, Gautam SC., Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects., Biochem Pharmacol. 2003 Dec 15;66(12):2427-35.
  31. Losa GA., Resveratrol modulates apoptosis and oxidation in human blood mononuclear cells., Eur J Clin Invest. 2003 Sep;33(9):818-23.
  32. Boscolo P, del Signore A, Sabbioni E, Di Gioacchino M, Di Giampaolo L, Reale M, Conti P, Paganelli R, Giaccio M., Effects of resveratrol on lymphocyte proliferation and cytokine release., Ann Clin Lab Sci. 2003 Spring;33(2):226-31.
  33. Dallal O, Ravindranath TM, Choudhry MA, Kohn A, Muraskas JK, Namak SY, Alattar MH, Sayeed MM., T-cell proliferative responses following sepsis in neonatal rats., Biol Neonate. 2003;83(3):201-7.
  34. Feng YH, Zhou WL, Wu QL, Li XY, Zhao WM, Zou JP., Low dose of resveratrol enhanced immune response of mice., Acta Pharmacol Sin. 2002 Oct;23(10):893-7.
  35. Bhat KP, Pezzuto JM., Cancer chemopreventive activity of resveratrol., Ann N Y Acad Sci. 2002 May;957:210-29.
  36. Ignatowicz E, Baer-Dubowska W., Resveratrol, a natural chemopreventive agent against degenerative diseases., Pol J Pharmacol. 2001Nov-Dec;53(6):557-69.
  37. Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G., Effects of resveratrol on human immune cell function., Life Sci. 2001 Nov 21;70(1):81-96.
  38. Gao X, Xu YX, Janakiraman N, Chapman RA, Gautam SC., Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production., Biochem Pharmacol. 2001 Nov 1;62(9):1299-308.
  39. Schneider Y, Duranton B, Gossé F, Schleiffer R, Seiler N, Raul F., Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis., Nutr Cancer. 2001;39(1):102-7.
  40. Bertelli AA, Ferrara F, Diana G, Fulgenzi A, Corsi M, Ponti W, Ferrero ME, Bertelli A., Resveratrol, a natural stilbene in grapes and wine, enhances intraphagocytosis in human promonocytes: a co-factor in antiinflammatory and anticancer chemopreventive activity., Int J Tissue React. 1999;21(4):93-104.
  41. Wadsworth TL, Koop DR., Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages., Biochem Pharmacol. 1999 Apr 15;57(8):941-9.
  42. Tan Y, Lim LH., trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation., Br J Pharmacol. 2008 Sep 8.
  43. Dave M, Attur M, Palmer G, Al-Mussawir HE, Kennish L, Patel J, Abramson SB., The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production., Arthritis Rheum. 2008 Sep;58(9):2786-97.
  44. Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB., Natural products as a gold mine for arthritis treatment., Curr Opin Pharmacol. 2007 Jun;7(3):344-51. Epub 2007 May 1.
  45. Inoue H., [Endogenous ligands for PPARs], Nippon Rinsho. 2005 Apr;63(4):578-83. [Japanese]
  46. Adams M, Pacher T, Greger H, Bauer R., Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species., J Nat Prod. 2005 Jan;68(1):83-5.
  47. Baolin L, Inami Y, Tanaka H, Inagaki N, Iinuma M, Nagai H., Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro., Planta Med. 2004 Apr;70(4):305-9.
  48. Shigematsu S, Ishida S, Hara M, Takahashi N, Yoshimatsu H, Sakata T, Korthuis RJ., Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants., Free Radic Biol Med. 2003 Apr 1;34(7):810-7.
  49. Huang KS, Lin M, Cheng GF., Anti-inflammatory tetramers of resveratrol from the roots of Vitis amurensis and the conformations of the seven-membered ring in some oligostilbenes., Phytochemistry. 2001 Sep;58(2):357-62.
  50. Schwartz Z, Sylvia VL, Del Toro F, Hardin RR, Dean DD, Boyan BD., 24R,25-(OH)(2)D(3) mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A(2) and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes., J Cell Physiol. 2000 Mar;182(3):390-401.
  51. MacCarrone M, Lorenzon T, Guerrieri P, Agrň AF., Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity., Eur J Biochem. 1999 Oct 1;265(1):27-34.
  52. Knight J, Taylor GW, Wright P, Clare AS, Rowley AF., Eicosanoid biosynthesis in an advanced deuterostomate invertebrate, the sea squirt (Ciona intestinalis)., Biochim Biophys Acta. 1999 Jan 4;1436(3):467-78.
  53. Hall LM, Murphy RC., Electrospray mass spectrometric analysis of 5-hydroperoxy and 5-hydroxyeicosatetraenoic acids generated by lipid peroxidation of red blood cell ghost phospholipids., J Am Soc Mass Spectrom. 1998 May;9(5):527-32.
  54. Rotondo S, Rajtar G, Manarini S, Celardo A, Rotillo D, de Gaetano G, Evangelista V, Cerletti C., Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function., Br J Pharmacol. 1998 Apr;123(8):1691-9.
  55. Soleas GJ, Diamandis EP, Goldberg DM., Wine as a biological fluid: history, production, and role in disease prevention., J Clin Lab Anal. 1997;11(5):287-313.
  56. Kimura Y, Okuda H, Kubo M., Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes., J Ethnopharmacol. 1995 Feb;45(2):131-9.
  57. Pendurthi UR, Rao LV., Resveratrol suppresses agonist-induced monocyte adhesion to cultured human endothelial cells., Thromb Res. 2002 May 15;106(4-5):243-8.
  58. Do GM, Kwon EY, Kim HJ, Jeon SM, Ha TY, Park T, Choi MS., Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice., Biochem Biophys Res Commun. 2008 Sep 12;374(1):55-9.
  59. Zhou M, He JL, Yu SQ, Zhu RF, Lu J, Ding FY, Xu GL., [Effect of resveratrol on chronic obstructive pulmonary disease in rats and its mechanism], Yao Xue Xue Bao. 2008 Feb;43(2):128-32. [Chinese]
  60. Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R, Ballabh P, Ungvari Z., Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations., Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35.
  61. Harikumar KB, Aggarwal BB., Resveratrol: a multitargeted agent for age-associated chronic diseases., Cell Cycle. 2008 Apr;7(8):1020-35.
  62. Namazi H., A novel molecular mechanism to account for the action of resveratrol against reperfusion injury., Ann Vasc Surg. 2008 May-Jun;22(3):492.
  63. Bukowska A, Schild L, Keilhoff G, Hirte D, Neumann M, Gardemann A, Neumann KH, Röhl FW, Huth C, Goette A, Lendeckel U., Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia., Exp Biol Med (Maywood). 2008 May;233(5):558-74.
  64. Yu HP, Hsu JC, Hwang TL, Yen CH, Lau YT., Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway., Shock. 2008 Sep;30(3):324-8.
  65. Csiszar A, Smith K, Labinskyy N, Orosz Z, Rivera A, Ungvari Z., Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1694-9.
  66. Wung BS, Hsu MC, Wu CC, Hsieh CW., Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways., Pharmacol Res. 2006 Feb;53(2):113-22.
  67. Kaplan S, Morgan JA, Bisleri G, Cheema FH, Akman HO, Topkara VK, Oz MC., Effects of resveratrol in storage solution on adhesion molecule expression and nitric oxide synthesis in vein grafts., Ann Thorac Surg. 2005 Nov;80(5):1773-8.
  68. Uchida Y, Yamazaki H, Watanabe S, Hayakawa K, Meng Y, Hiramatsu N, Kasai A, Yamauchi K, Yao J, Kitamura M., Enhancement of NF-kappaB activity by resveratrol in cytokine-exposed mesangial cells., Clin Exp Immunol. 2005 Oct;142(1):76-83.
  69. Wung BS, Hsu MC, Wu CC, Hsieh CW., Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation., Life Sci. 2005 Dec 12;78(4):389-97.
  70. Leiro J, Arranz JA, Fraiz N, Sanmartín ML, Quezada E, Orallo F., Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling., Int Immunopharmacol. 2005 Feb;5(2):393-406.
  71. Meng Y, Zhang M, Xu J, Liu XM, Ma QY., Effect of resveratrol on microcirculation disorder and lung injury following severe acute pancreatitis in rats., World J Gastroenterol. 2005 Jan 21;11(3):433-5.
  72. Ahn KS, Kim JH, Oh SR, Ryu SY, Lee HK., Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells., Planta Med. 2000 Oct;66(7):641-4.
  73. Ferrero ME, Bertelli AE, Fulgenzi A, Pellegatta F, Corsi MM, Bonfrate M, Ferrara F, De Caterina R, Giovannini L, Bertelli A., Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium., Am J Clin Nutr. 1998 Dec;68(6):1208-14.

Inhibit LDL oxidation resveratrol research

  1. Dong HH, Ren HL., New progression in the study of protective properties of resveratrol in anticardiovascular disease., Bratisl Lek Listy. 2004;105(5-6):225-9.
  2. Bradamante S, Barenghi L, Villa A., Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.
  3. Kollár P, Hotolová H., [Biological effects of resveratrol and other constituents of wine] Ceska Slov Farm. 2003 Nov;52(6):272-81. [Czech.]
  4. Brito P, Almeida LM, Dinis TC., The interaction of resveratrol with ferrylmyoglobin and peroxynitrite; protection against LDL oxidation., Free Radic Res. 2002 Jun;36(6):621-31.
  5. Zou JG, Huang YZ, Chen Q, Wei EH, Hsieh TC, Wu JM., Resveratrol inhibits copper ion-induced and azo compound-initiated oxidative modification of human low density lipoprotein., Biochem Mol Biol Int. 1999 Jun;47(6):1089-96.
  6. Belguendouz L, Fremont L, Linard A., Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins., Biochem Pharmacol. 1997 May 9;53(9):1347-55.

Prostate Cancer and Resveratrol Clinical trials references Resveratrol research

  1. Vidavalur R, Otani H, Singal PK, Maulik N., Significance of wine and resveratrol in cardiovascular disease: French paradox revisited., Exp Clin Cardol. 2006 Fall;11(3):217-25.
  2. Wang TT, Hudson TS, Wang TC, Remsberg CM, Davies NM, Takahashi Y, Kim YS, Seifried H, Vinyard BT, Perkins SN, Hursting SD., Differential Effects of Resveratrol on Androgen-responsive LNCaP Human Prostate Cancer Cells In Vitro and In Vivo., Carcinogenesis. 2008 Jun 26.
  3. Snyder RM, Yu W, Jia L, Sanders BG, Kline K., Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth., Nutr Cancer. 2008 May-Jun;60(3):401-11.
  4. Seeni A, Takahashi S, Takeshita K, Tang M, Sugiura S, Sato SY, Shirai T., Suppression of Prostate Cancer Growth by Resveratrol in The Transgenic Rat for Adenocarcinoma of Prostate (TRAP) Model., Asian Pac J Cancer Prev. 2008 Jan-Mar;9(1):7-14.
  5. Hsieh TC, Wang Z, Deng H, Wu JM., Identification of glutathione sulfotransferase-pi (GSTP1) as a new resveratrol targeting protein (RTP) and studies of resveratrol-responsive protein changes by resveratrol affinity chromatography., Anticancer Res. 2008 Jan-Feb;28(1A):29-36.
  6. Harada N, Murata Y, Yamaji R, Miura T, Inui H, Nakano Y., Resveratrol down-regulates the androgen receptor at the post-translational level in prostate cancer cells. J Nutr Sci Vitaminol (Tokyo). 2007 Dec;53(6):556-60.
  7. Khan N, Afaq F, Mukhtar H., Cancer chemoprevention through dietary antioxidants: progress and promise., Antioxid Redox Signal. 2008 Mar;10(3):475-510.
  8. Zahid M, Gaikwad NW, Rogan EG, Cavalieri EL., Inhibition of depurinating estrogen-DNA adduct formation by natural compounds., Chem Res Toxicol. 2007 Dec;20(12):1947-53.
  9. Sallman DA, Chen X, Zhong B, Gilvary DL, Zhou J, Wei S, Djeu JY., Clusterin mediates TRAIL resistance in prostate tumor cells., Mol Cancer Ther. 2007 Nov;6(11):2938-47.
  10. Horvath Z, Marihart-Fazekas S, Saiko P, Grusch M, Ozsüy M, Harik M, Handler N, Erker T, Jaeger W, Fritzer-Szekeres M, Djavan B, Szekeres T., Novel resveratrol derivatives induce apoptosis and cause cell cycle arrest in prostate cancer cell lines., Anticancer Res. 2007 Sep-Oct;27(5A):3459-64.
  11. Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, Watson RW., Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms., Prostate. 2007 Nov 1;67(15):1641-53.
  12. Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE., Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms., Cancer Res. 2007 Sep 1;67(17):8396-405.
  13. Shankar S, Chen Q, Siddiqui I, Sarva K, Srivastava RK., Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential. J Mol Signal. 2007 Aug 24;2:7.
  14. Djavan B, Marihart S, Kuehhas F, Rom M, Partin A, Schalken J, Sekeres T., [Resveratrol and newly synthetized resveratrol analogs in therapy of prostate carcinoma], Urologe A. 2007 Sep;46(9):1101-3. [German]
  15. Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA., Resveratrol suppresses prostate cancer progression in transgenic mice., Carcinogenesis. 2007 Sep;28(9):1946-53.
  16. Shankar S, Siddiqui I, Srivastava RK., Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells., Mol Cell Biochem. 2007 Oct;304(1-2):273-85. Epub 2007 Jul 17.
  17. Cardile V, Chillemi R, Lombardo L, Sciuto S, Spatafora C, Tringali C., Antiproliferative activity of methylated analogues of E- and Z-resveratrol., Z Naturforsch [C]. 2007 Mar-Apr;62(3-4):189-95.
  18. Wietrzyk J., [The influence of isoflavonoids on the antitumor activity of vitamin D3] Postepy Hig Med Dosw (Online). 2007;61:253-60. [Polish]
  19. Benitez DA, Pozo-Guisado E, Clementi M, Castellón E, Fernandez-Salguero PM., Non-genomic action of resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway., Br J Cancer. 2007 May 21;96(10):1595-604.
  20. Von Löw EC, Perabo FG, Siener R, Müller SC., Review. Facts and fiction of phytotherapy for prostate cancer: a critical assessment of preclinical and clinical data., In Vivo. 2007 Mar-Apr;21(2):189-204.
  21. Ahmad KA, Harris NH, Johnson AD, Lindvall HC, Wang G, Ahmed K., Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells., Mol Cancer Ther. 2007 Mar;6(3):1006-12.
  22. Scarlatti F, Sala G, Ricci C, Maioli C, Milani F, Minella M, Botturi M, Ghidoni R., Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase., Cancer Lett. 2007 Aug 8;253(1):124-30. Epub 2007 Feb 26.
  23. Landis-Piwowar KR, Milacic V, Chen D, Yang H, Zhao Y, Chan TH, Yan B, Dou QP., The proteasome as a potential target for novel anticancer drugs and chemosensitizers. Drug Resist Updat. 2006 Dec;9(6):263-73.
  24. Narayanan BA., Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets., Curr Cancer Drug Targets. 2006 Dec;6(8):711-27.
  25. Nonn L, Duong D, Peehl DM., Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells., Carcinogenesis. 2007 Jun;28(6):1188-96.
  26. Benitez DA, Pozo-Guisado E, Alvarez-Barrientos A, Fernandez-Salguero PM, Castellón EA., Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines., J Androl. 2007 Mar-Apr;28(2):282-93.
  27. Bemis DL, Katz AE, Buttyan R., Clinical trials of natural products as chemopreventive agents for prostate cancer., Expert Opin Investig Drugs. 2006 Oct;15(10):1191-200.
  28. Aziz MH, Nihal M, Fu VX, Jarrard DF, Ahmad N., Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins., Mol Cancer Ther. 2006 May;5(5):1335-41.
  29. Yoo KM, Kim S, Moon BK, Kim SS, Kim KT, Kim SY, Choi SY., Potent inhibitory effects of resveratrol derivatives on progression of prostate cancer cells., Arch Pharm (Weinheim). 2006 May;339(5):238-41.
  30. Scifo C, Milasi A, Guarnera A, Sinatra F, Renis M., Resveratrol and propolis extract: an insight into the morphological and molecular changes induced in DU145 cells., Oncol Res. 2006;15(9):409-21.
  31. Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, Zervos AS, Carter B, Turkson J, Jove R., Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein., Mol Cancer Ther. 2006 Mar;5(3):621-9.
  32. Jones SB, DePrimo SE, Whitfield ML, Brooks JD., Resveratrol-induced gene expression profiles in human prostate cancer cells., Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604.
  33. Cardile V, Lombardo L, Spatafora C, Tringali C., Chemo-enzymatic synthesis and cell-growth inhibition activity of resveratrol analogues., Bioorg Chem. 2005 Feb;33(1):22-33.
  34. Awad AB, Burr AT, Fink CS., Effect of resveratrol and beta-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells., Prostaglandins Leukot Essent Fatty Acids. 2005 Mar;72(3):219-26.
  35. Manson MM, Farmer PB, Gescher A, Steward WP., Innovative agents in cancer prevention., Recent Results Cancer Res. 2005;166:257-75.
  36. Narayanan NK, Narayanan BA, Nixon DW., Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evaluation., Cancer Detect Prev. 2004;28(6):443-52.
  37. Shih A, Zhang S, Cao HJ, Boswell S, Wu YH, Tang HY, Lennartz MR, Davis FB, Davis PJ, Lin HY., Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha., Mol Cancer Ther. 2004 Nov;3(11):1355-64.
  38. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y., Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.
  39. Scifo C, Cardile V, Russo A, Consoli R, Vancheri C, Capasso F, Vanella A, Renis M., Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells., Oncol Res. 2004;14(9):415-26.
  40. Shenouda NS, Zhou C, Browning JD, Ansell PJ, Sakla MS, Lubahn DB, Macdonald RS., Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro., Nutr Cancer. 2004;49(2):200-8.
  41. Wang Z, Hsieh TC, Zhang Z, Ma Y, Wu JM., Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography., Biochem Biophys Res Commun. 2004 Oct 22;323(3):743-9.
  42. Yuan H, Pan Y, Young CY., Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells., Cancer Lett. 2004 Sep 30;213(2):155-63.
  43. Simopoulos AP., The traditional diet of Greece and cancer., Eur J Cancer Prev. 2004 Jun;13(3):219-30.
  44. Sala G, Minutolo F, Macchia M, Sacchi N, Ghidoni R., Resveratrol structure and ceramide-associated growth inhibition in prostate cancer cells., Drugs Exp Clin Res. 2003;29(5-6):263-9.
  45. Gao S, Liu GZ, Wang Z., Modulation of androgen receptor-dependent transcription by resveratrol and genistein in prostate cancer cells., Prostate. 2004 May 1;59(2):214-25.
  46. Cardile V, Scifo C, Russo A, Falsaperla M, Morgia G, Motta M, Renis M, Imbriani E, Silvestre G., Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer., Anticancer Res. 2003 Nov-Dec;23(6C):4921-6.
  47. Kim YA, Rhee SH, Park KY, Choi YH., Antiproliferative effect of resveratrol in human prostate carcinoma cells., J Med Food. 2003 Winter;6(4):273-80.
  48. Ho SM., Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates., J Cell Biochem. 2004 Feb 15;91(3):491-503.
  49. Stewart JR, O'Brian CA., Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition., Invest New Drugs. 2004 Apr;22(2):107-17.
  50. Fulda S, Debatin KM., Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol., Cancer Res. 2004 Jan 1;64(1):337-46.
  51. Carraway RE, Hassan S, Cochrane DE., Polyphenolic antioxidants mimic the effects of 1,4-dihydropyridines on neurotensin receptor function in PC3 cells., J Pharmacol Exp Ther. 2004 Apr;309(1):92-101.
  52. Stewart JR, Artime MC, O'Brian CA., Resveratrol: a candidate nutritional substance for prostate cancer prevention., J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
  53. Aziz MH, Kumar R, Ahmad N., Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review)., Int J Oncol. 2003 Jul;23(1):17-28. Peter Guengerich F, Chun YJ, Kim D, Gillam EM, Shimada T., Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies., Mutat Res. 2003 Feb-Mar;523-524:173-82.
  54. Narayanan BA, Narayanan NK, Re GG, Nixon DW., Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets., Int J Cancer. 2003 Mar 20;104(2):204-12.
  55. Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, Griel AE, Etherton TD., Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer., Am J Med. 2002 Dec 30;113 Suppl 9B:71S-88S.
  56. Deeb D, Xu YX, Jiang H, Gao X, Janakiraman N, Chapman RA, Gautam SC., Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells., Mol Cancer Ther. 2003 Jan;2(1):95-103.
  57. Ratan HL, Steward WP, Gescher AJ, Mellon JK., Resveratrol--a prostate cancer chemopreventive agent?, Urol Oncol. 2002 Nov-Dec;7(6):223-7.
  58. Ding XZ, Adrian TE., Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells., Pancreas. 2002 Nov;25(4):e71-6.
  59. Culig Z, Klocker H, Bartsch G, Hobisch A., Androgen receptors in prostate cancer. Endocr Relat Cancer. 2002 Sep;9(3):155-70.
  60. Morris GZ, Williams RL, Elliott MS, Beebe SJ., Resveratrol induces apoptosis in LNCaP cells and requires hydroxyl groups to decrease viability in LNCaP and DU 145 cells., Prostate. 2002 Sep 1;52(4):319-29.
  61. Lin HY, Shih A, Davis FB, Tang HY, Martino LJ, Bennett JA, Davis PJ., Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line., J Urol. 2002 Aug;168(2):748-55.
  62. Narayanan BA, Narayanan NK, Stoner GD, Bullock BP., Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants., Life Sci. 2002 Mar 1;70(15):1821-39.
  63. Kuwajerwala N, Cifuentes E, Gautam S, Menon M, Barrack ER, Reddy GP., Resveratrol induces prostate cancer cell entry into s phase and inhibits DNA synthesis., Cancer Res. 2002 May 1;62(9):2488-92.
  64. Sgambato A, Ardito R, Faraglia B, Boninsegna A, Wolf FI, Cittadini A., Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage., Mutat Res. 2001 Sep 20;496(1-2):171-80.
  65. Cuendet M, Pezzuto JM., The role of cyclooxygenase and lipoxygenase in cancer chemoprevention., Drug Metabol Drug Interact. 2000;17(1-4):109-57.
  66. Kampa M, Hatzoglou A, Notas G, Damianaki A, Bakogeorgou E, Gemetzi C, Kouroumalis E, Martin PM, Castanas E., Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines., Nutr Cancer. 2000;37(2):223-33.
  67. Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C, Kouroumalis E, Martin PM, Castanas E., Potent inhibitory action of red wine polyphenols on human breast cancer cells., J Cell Biochem. 2000 Jun 6;78(3):429-41.
  68. Hsieh TC, Wu JM., Grape-derived chemopreventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by an androgen receptor (AR)-independent mechanism., Anticancer Res. 2000 Jan-Feb;20(1A):225-8.
  69. Mitchell SH, Zhu W, Young CY., Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells., Cancer Res. 1999 Dec 1;59(23):5892-5. Weisburger JH., Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea., Food Chem Toxicol. 1999 Sep-Oct;37(9-10):943-8.
  70. Ulsperger E, Hamilton G, Raderer M, Baumgartner G, Hejna M, Hoffmann O, Mallinger R., Resveratrol pretreatment desensitizes AHTO-7 human osteoblasts to growth stimulation in response to carcinoma cell supernatants., Int J Oncol. 1999 Nov;15(5):955-9.
  71. Hsieh TC, Wu JM., Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines., Exp Cell Res. 1999 May 25;249(1):109-15.

Protein tyrosine kinase resveratrol research

  1. Ma HJ, Cao YK, Liu YX, Wang R, Wu YM., Microinjection of resveratrol into rostral ventrolateral medulla decreases sympathetic vasomotor tone through nitric oxide and intracellular Ca2+ in anesthetized male rats., Acta Pharmacol Sin. 2008 Aug;29(8):906-12.
  2. Venkatesan B, Ghosh-Choudhury N, Das F, Mahimainathan L, Kamat A, Kasinath BS, Abboud HE, Choudhury GG., Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B., FASEB J. 2008 Jun 20.
  3. Chakraborty PK, Mustafi SB, Ganguly S, Chatterjee M, Raha S., Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70., Cancer Sci. 2008 Jun;99(6):1109-16.
  4. Klinge CM, Wickramasinghe NS, Ivanova MM, Dougherty SM., Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells., FASEB J. 2008 Jul;22(7):2185-97.
  5. Lee KW, Kang NJ, Heo YS, Rogozin EA, Pugliese A, Hwang MK, Bowden GT, Bode AM, Lee HJ, Dong Z., Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine., Cancer Res. 2008 Feb 1;68(3):946-55.
  6. Sallman DA, Chen X, Zhong B, Gilvary DL, Zhou J, Wei S, Djeu JY., Clusterin mediates TRAIL resistance in prostate tumor cells., Mol Cancer Ther. 2007 Nov;6(11):2938-47.
  7. Ohshiro K, Rayala SK, El-Naggar AK, Kumar R., Delivery of cytoplasmic proteins to autophagosomes., Autophagy. 2008 Jan-Feb;4(1):104-6.
  8. Ohshiro K, Rayala SK, Kondo S, Gaur A, Vadlamudi RK, El-Naggar AK, Kumar R., Identifying the estrogen receptor coactivator PELP1 in autophagosomes., Cancer Res. 2007 Sep 1;67(17):8164-71.
  9. Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z., Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1., Carcinogenesis. 2007 Sep;28(9):1918-27.
  10. Wu CC, Wu CI, Wang WY, Wu YC., Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins., Planta Med. 2007 May;73(5):439-43.
  11. Su JL, Yang CY, Zhao M, Kuo ML, Yen ML., Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem. 2007 Jul 6;282(27):19385-98.
  12. Kutuk O, Basaga H., Apoptosis signalling by 4-hydroxynonenal: a role for JNK-c-Jun/AP-1 pathway., Redox Rep. 2007;12(1):30-4.
  13. Faber AC, Chiles TC., Resveratrol induces apoptosis in transformed follicular lymphoma OCI-LY8 cells: evidence for a novel mechanism involving inhibition of BCL6 signaling., Int J Oncol. 2006 Dec;29(6):1561-6.
  14. Fulda S, Debatin KM., Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review., Cancer Detect Prev. 2006;30(3):217-23.
  15. Ovesná Z, Kozics K, Bader Y, Saiko P, Handler N, Erker T, Szekeres T., Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines., Oncol Rep. 2006 Sep;16(3):617-24.
  16. Kim AL, Zhu Y, Zhu H, Han L, Kopelovich L, Bickers DR, Athar M., Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways., Exp Dermatol. 2006 Jul;15(7):538-46.
  17. Koo N, Cho D, Kim Y, Choi HJ, Kim KM., Effects of resveratrol on mast cell degranulation and tyrosine phosphorylation of the signaling components of the IgE receptor., Planta Med. 2006 Jun;72(7):659-61.
  18. Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, Zervos AS, Carter B, Turkson J, Jove R., Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein., Mol Cancer Ther. 2006 Mar;5(3):621-9.
  19. Choi HK, Yang JW, Kang KW., Bifunctional effect of resveratrol on the expression of ErbB2 in human breast cancer cell., Cancer Lett. 2006 Oct 28;242(2):198-206.
  20. Fukuda S, Kaga S, Zhan L, Bagchi D, Das DK, Bertelli A, Maulik N., Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1., Cell Biochem Biophys. 2006;44(1):43-9.
  21. Li X, Zhang S, Safe S., Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds., J Steroid Biochem Mol Biol. 2006 Feb;98(2-3):122-32.
  22. Zhang LP, Yin JX, Liu Z, Zhang Y, Wang QS, Zhao J., Effect of resveratrol on L-type calcium current in rat ventricular myocytes., Acta Pharmacol Sin. 2006 Feb;27(2):179-83.
  23. Juan SH, Lee JL, Ho PY, Lee YH, Lee WS., Antiproliferative and antiangiogenic effects of 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, in human umbilical vascular endothelial cells., Eur J Pharmacol. 2006 Jan 13;530(1-2):1-8.
  24. Kutuk O, Poli G, Basaga H., Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1signaling., Toxicol Sci. 2006 Mar;90(1):120-32.
  25. Wung BS, Hsu MC, Wu CC, Hsieh CW., Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways., Pharmacol Res. 2006 Feb;53(2):113-22.
  26. Liu Z, Zhang LP, Ma HJ, Wang C, Li M, Wang QS., Resveratrol reduces intracellular free calcium concentration in rat ventricular myocytes., Sheng Li Xue Bao. 2005 Oct 25;57(5):599-604.
  27. Chan WH, Chang YJ., Dosage effects of resveratrol on ethanol-induced cell death in the human K562 cell line., Toxicol Lett. 2006 Feb 8;161(1):1-9.
  28. Tyagi A, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R., Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells., Carcinogenesis. 2005 Nov;26(11):1978-87.
  29. Morris BJ., A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer., J Hypertens. 2005 Jul;23(7):1285-309.
  30. Das S, Alagappan VK, Bagchi D, Sharma HS, Maulik N, Das DK., Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart., Vascul Pharmacol. 2005 Apr-May;42(5-6):281-9.
  31. Haider UG, Roos TU, Kontaridis MI, Neel BG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM., Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2., Mol Pharmacol. 2005 Jul;68(1):41-8.
  32. Azios NG, Dharmawardhane SF., Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells., Neoplasia. 2005 Feb;7(2):128-40.
  33. Chan WH., Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells., J Cell Biochem. 2005 Apr 15;94(6):1267-79.
  34. Provinciali M, Re F, Donnini A, Orlando F, Bartozzi B, Di Stasio G, Smorlesi A., Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice., Int J Cancer. 2005 May 20;115(1):36-45.
  35. Klinge CM, Blankenship KA, Risinger KE, Bhatnagar S, Noisin EL, Sumanasekera WK, Zhao L, Brey DM, Keynton RS., Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells., J Biol Chem. 2005 Mar 4;280(9):7460-8.
  36. Evers DL, Wang X, Huong SM, Huang DY, Huang ES., 3,4',5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling., Antiviral Res. 2004 Aug;63(2):85-95.
  37. Guastalla JP, Bachelot T, Ray-Coquard I., [Cyclooxygenase 2 and breast cancer. From biological concepts to therapeutic trials], Bull Cancer. 2004 May;91 Spec No:S99-108. [French]
  38. Storz P, Döppler H, Toker A., Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB., Mol Pharmacol. 2004 Oct;66(4):870-9. Epub 2004 Jun 29.
  39. Conte A, Pellegrini S, Tagliazucchi D., Effect of resveratrol and catechin on PC12 tyrosine kinase activities and their synergistic protection from beta-amyloid toxicity., Drugs Exp Clin Res. 2003;29(5-6):243-55.
  40. Reagan-Shaw S, Afaq F, Aziz MH, Ahmad N., Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin., Oncogene. 2004 Jul 1;23(30):5151-60.
  41. Andrieux L, Langouët S, Fautrel A, Ezan F, Krauser JA, Savouret JF, Guengerich FP, Baffet G, Guillouzo A., Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes., Mol Pharmacol. 2004 Apr;65(4):934-43.
  42. Stewart JR, O'Brian CA., Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition., Invest New Drugs. 2004 Apr;22(2):107-17.
  43. Kubota T, Uemura Y, Kobayashi M, Taguchi H., Combined effects of resveratrol and paclitaxel on lung cancer cells., Anticancer Res. 2003 Sep-Oct;23(5A):4039-46.
  44. Woo JH, Lim JH, Kim YH, Suh SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK., Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction., Oncogene. 2004 Mar 11;23(10):1845-53.
  45. Arakaki N, Nagao T, Niki R, Toyofuku A, Tanaka H, Kuramoto Y, Emoto Y, Shibata H, Magota K, Higuti T., Possible role of cell surface H+ -ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells., Mol Cancer Res. 2003 Nov;1(13):931-9.
  46. Lin MT, Yen ML, Lin CY, Kuo ML., Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation., Mol Pharmacol. 2003 Nov;64(5):1029-36.
  47. Stewart JR, Artime MC, O'Brian CA., Resveratrol: a candidate nutritional substance for prostate cancer prevention., J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
  48. Maccaglia A, Mallozzi C, Minetti M., Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells., Biochem Biophys Res Commun. 2003 Jun 6;305(3):541-7.
  49. Liang YC, Tsai SH, Chen L, Lin-Shiau SY, Lin JK., Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells., Biochem Pharmacol. 2003 Apr 1;65(7):1053-60.
  50. Della Ragione F, Cucciolla V, Criniti V, Indaco S, Borriello A, Zappia V., Antioxidants induce different phenotypes by a distinct modulation of signal transduction., FEBS Lett. 2002 Dec 18;532(3):289-94.
  51. Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB., Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation., J Immunol. 2002 Dec 1;169(11):6490-7.
  52. Brownson DM, Azios NG, Fuqua BK, Dharmawardhane SF, Mabry TJ., Flavonoid effects relevant to cancer., J Nutr. 2002 Nov;132(11 Suppl):3482S-3489S.
  53. Tou JS., Differential regulation of neutrophil phospholipase d activity and degranulation., Biochem Biophys Res Commun. 2002 Apr 12;292(4):951-6.
  54. Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML., Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase., Free Radic Biol Med. 2002 Apr 1;32(7):650-62. Erratum in: Free Radic Biol Med 2002 Jul 31;33(1):149. Guis David [corrected to Gius David].
  55. Kong AN, Yu R, Hebbar V, Chen C, Owuor E, Hu R, Ee R, Mandlekar S., Signal transduction events elicited by cancer prevention compounds., Mutat Res. 2001 Sep 1;480-481:231-41.
  56. De Lédinghen V, Monvoisin A, Neaud V, Krisa S, Payrastre B, Bedin C, Desmouličre A, Bioulac-Sage P, Rosenbaum J., Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells., Int J Oncol. 2001 Jul;19(1):83-8.
  57. Yu R, Hebbar V, Kim DW, Mandlekar S, Pezzuto JM, Kong AN., Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways., Mol Pharmacol. 2001 Jul;60(1):217-24.
  58. Shih A, Lin HY, Davis FB, Davis PJ., Thyroid hormone promotes serine phosphorylation of p53 by mitogen-activated protein kinase., Biochemistry. 2001 Mar 6;40(9):2870-8.
  59. She QB, Bode AM, Ma WY, Chen NY, Dong Z., Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase., Cancer Res. 2001 Feb 15;61(4):1604-10.
  60. Bruder JL, Hsieh T, Lerea KM, Olson SC, Wu JM., Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress., BMC Cell Biol. 2001;2:1.
  61. Saijonmaa O, Nyman T, Kosonen R, Fyhrquist F., Upregulation of angiotensin-converting enzyme by vascular endothelial growth factor., Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H885-91.
  62. Lin JK, Tsai SH., Chemoprevention of cancer and cardiovascular disease by resveratrol., Proc Natl Sci Counc Repub China B. 1999 Jul;23(3):99-106.
  63. Palmieri L, Mameli M, Ronca G., Effect of resveratrol and some other natural compounds on tyrosine kinase activity and on cytolysis., Drugs Exp Clin Res. 1999;25(2-3):79-85.
  64. El-Mowafy AM, White RE., Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects., FEBS Lett. 1999 May 14;451(1):63-7.
  65. Lu R, Serrero G., Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells., J Cell Physiol. 1999 Jun;179(3):297-304.
  66. Ferrero ME, Bertelli AE, Fulgenzi A, Pellegatta F, Corsi MM, Bonfrate M, Ferrara F, De Caterina R, Giovannini L, Bertelli A., Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium., Am J Clin Nutr. 1998 Dec;68(6):1208-14.
  67. Kawada N, Seki S, Inoue M, Kuroki T., Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells., Hepatology. 1998 May;27(5):1265-74.
  68. Jayatilake GS, Jayasuriya H, Lee ES, Koonchanok NM, Geahlen RL, Ashendel CL, McLaughlin JL, Chang CJ., Kinase inhibitors from Polygonum cuspidatum., J Nat Prod. 1993 Oct;56(10):1805-10.

Reducing heart attack and stroke injury resveratrol research

  1. Penumathsa SV, Koneru S, Samuel SM, Maulik G, Bagchi D, Yet SF, Menon VP, Maulik N., Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: Role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor., Free Radic Biol Med. 2008 Jul 27.
  2. Lin JF, Lin SM, Chih CL, Nien MW, Su HH, Hu BR, Huang SS, Tsai SK., Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in rats., Life Sci. 2008 Jun 27.
  3. Lekli I, Szabo G, Juhasz B, Das S, Das M, Varga E, Szendrei L, Gesztelyi R, Varadi J, Bak I, Das DK, Tosaki A., Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H859-66.
  4. Burstein B, Maguy A, Clément R, Gosselin H, Poulin F, Ethier N, Tardif JC, Hébert TE, Calderone A, Nattel S., Effects of resveratrol (trans-3,5,4'-trihydroxystilbene) treatment on cardiac remodeling following myocardial infarction., J Pharmacol Exp Ther. 2007 Dec;323(3):916-23.
  5. Cruz MN, Agewall S, Schenck-Gustafsson K, Kublickiene K., Acute dilatation to phytoestrogens and estrogen receptor subtypes expression in small arteries from women with coronary heart disease., Atherosclerosis. 2008 Jan;196(1):49-58. Epub 2007 Mar 23.
  6. Das S, Falchi M, Bertelli A, Maulik N, Das DK., Attenuation of ischemia/reperfusion injury in rats by the anti-inflammatory action of resveratrol., Arzneimittelforschung. 2006;56(10):700-6.
  7. Penumathsa SV, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, Pant R, Menon VP, Otani H, Maulik N., Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat., J Mol Cell Cardiol. 2007 Mar;42(3):508-16.
  8. Vigne P, Frelin C., A low protein diet increases the hypoxic tolerance in Drosophila., PLoS ONE. 2006 Dec 20;1:e56.,
  9. Bezstarosti K, Das S, Lamers JM, Das DK., Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol., J Cell Mol Med. 2006 Oct-Dec;10(4):896-907.
  10. Maulik N., Reactive oxygen species drives myocardial angiogenesis?, Antioxid Redox Signal. 2006 Nov-Dec;8(11-12):2161-8.
  11. Das S, Fraga CG, Das DK., Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB., Free Radic Res. 2006 Oct;40(10):1066-75.
  12. Baur JA, Sinclair DA., Therapeutic potential of resveratrol: the in vivo evidence., Nat Rev Drug Discov. 2006 Jun;5(6):493-506. Epub 2006 May 26.
  13. Bak I, Lekli I, Juhasz B, Nagy N, Varga E, Varadi J, Gesztelyi R, Szabo G, Szendrei L, Bacskay I, Vecsernyes M, Antal M, Fesus L, Boucher F, de Leiris J, Tosaki A., Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts., Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1329-36. Das S, Tosaki A, Bagchi D, Maulik N, Das DK., Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J Pharmacol Exp Ther. 2006 Jun;317(3):980-8.
  14. Fukuda S, Kaga S, Zhan L, Bagchi D, Das DK, Bertelli A, Maulik N., Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1., Cell Biochem Biophys. 2006;44(1):43-9.
  15. Cruz MN, Luksha L, Logman H, Poston L, Agewall S, Kublickiene K., Acute responses to phytoestrogens in small arteries from men with coronary heart disease., Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1969-75.
  16. Morelli R, Das S, Bertelli A, Bollini R, Lo Scalzo R, Das DK, Falchi M., The introduction of the stilbene synthase gene enhances the natural antiradical activity of Lycopersicon esculentum mill., Mol Cell Biochem. 2006 Jan;282(1-2):65-73.
  17. Kaga S, Zhan L, Matsumoto M, Maulik N., Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor., J Mol Cell Cardiol. 2005 Nov;39(5):813-22.
  18. Das S, Alagappan VK, Bagchi D, Sharma HS, Maulik N, Das DK., Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart., Vascul Pharmacol. 2005 Apr-May;42(5-6):281-9.
  19. Das S, Tosaki A, Bagchi D, Maulik N, Das DK., Resveratrol-mediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways., J Pharmacol Exp Ther. 2005 Aug;314(2):762-9.
  20. Szmitko PE, Verma S., Cardiology patient pages. Red wine and your heart., Circulation. 2005 Jan 18;111(2):e10-1.
  21. Das S, Cordis GA, Maulik N, Das DK., Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation., Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H328-35.
  22. Hung LM, Su MJ, Chen JK., Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms., Free Radic Biol Med. 2004 Mar 15;36(6):774-81.
  23. Sato M, Maulik N, Das DK., Cardioprotection with alcohol: role of both alcohol and polyphenolic antioxidants., Ann N Y Acad Sci. 2002 May;957:122-35.
  24. Cui J, Tosaki A, Bertelli AA, Bertelli A, Maulik N, Das DK., Cardioprotection with white wine., Drugs Exp Clin Res. 2002;28(1):1-10.
  25. Imamura G, Bertelli AA, Bertelli A, Otani H, Maulik N, Das DK., Pharmacological preconditioning with resveratrol: an insight with iNOS knockout mice., Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H1996-2003.
  26. Hattori R, Otani H, Maulik N, Das DK., Pharmacological preconditioning with resveratrol: role of nitric oxide., Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H1988-95.
  27. Hale SL, Kloner RA., Effects of resveratrol, a flavinoid found in red wine, on infarct size in an experimental model of ischemia/reperfusion., J Stud Alcohol. 2001 Nov;62(6):730-5.
  28. Russo P, Tedesco I, Russo M, Russo GL, Venezia A, Cicala C., Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation., Nutr Metab Cardiovasc Dis. 2001 Feb;11(1):25-9.
  29. Hung LM, Chen JK, Lee RS, Liang HC, Su MJ., Beneficial effects of astringinin, a resveratrol analogue, on the ischemia and reperfusion damage in rat heart., Free Radic Biol Med. 2001 Apr 15;30(8):877-83.
  30. Bradamante S, Piccinini F, Barenghi L, Bertelli AA, De Jonge R, Beemster P, De Jong JW., Does resveratrol induce pharmacological preconditioning?, Int J Tissue React. 2000;22(1):1-4.
  31. Ballmer PE., [The Mediterranean diet--healthy but and still delicious], Ther Umsch. 2000 Mar;57(3):167-72. [German]
  32. Sato M, Ray PS, Maulik G, Maulik N, Engelman RM, Bertelli AA, Bertelli A, Das DK., Myocardial protection with red wine extract., J Cardiovasc Pharmacol. 2000 Feb;35(2):263-8.
  33. Sato M, Maulik G, Bagchi D, Das DK., Myocardial protection by protykin, a novel extract of trans-resveratrol and emodin., Free Radic Res. 2000 Feb;32(2):135-44.
  34. Ray PS, Maulik G, Cordis GA, Bertelli AA, Bertelli A, Das DK., The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury., Free Radic Biol Med. 1999 Jul;27(1-2):160-9.
  35. Constant J., Alcohol, ischemic heart disease, and the French paradox., Coron Artery Dis. 1997 Oct;8(10):645-9.
  36. Dong W, Li N, Gao D, Zhen H, Zhang X, Li F., Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors., J Vasc Surg. 2008 Jun 21.
  37. Ban JY, Cho SO, Choi SH, Ju HS, Kim JY, Bae K, Song KS, Seong YH., Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo., J Pharmacol Sci. 2008 Jan;106(1):68-77.
  38. Dong W, Gao D, Lin H, Zhang X, Li N, Li F., New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9., Med Hypotheses. 2008;70(1):52-5.
  39. Tsai SK, Hung LM, Fu YT, Cheng H, Nien MW, Liu HY, Zhang FB, Huang SS., Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats., J Vasc Surg. 2007 Aug;46(2):346-53.
  40. Dong W, Gao D, Zhang X., Mitochondria biogenesis induced by resveratrol against brain ischemic stroke., Med Hypotheses. 2007;69(3):700-1.
  41. Mokni M, Limam F, Elkahoui S, Amri M, Aouani E., Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury., Arch Biochem Biophys. 2007 Jan 1;457(1):1-6.
  42. Gao D, Zhang X, Jiang X, Peng Y, Huang W, Cheng G, Song L., Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia-reperfusion in mice., Life Sci. 2006 Apr 25;78(22):2564-70.
  43. Zhuang H, Kim YS, Koehler RC, Doré S., Potential mechanism by which resveratrol, a red wine constituent, protects neurons., Ann N Y Acad Sci. 2003 May;993:276-86; discussion 287-8.
  44. Ikeda K, Negishi H, Yamori Y., Antioxidant nutrients and hypoxia/ischemia brain injury in rodents., Toxicology. 2003 Jul 15;189(1-2):55-61.
  45. Sinha K, Chaudhary G, Gupta YK., Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats., Life Sci. 2002 Jun 28;71(6):655-65.
  46. Bagchi D, Das DK, Tosaki A, Bagchi M, Kothari SC., Benefits of resveratrol in women's health., Drugs Exp Clin Res. 2001;27(5-6):233-48.
  47. Huang SS, Tsai MC, Chih CL, Hung LM, Tsai SK., Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia., Life Sci. 2001 Jul 20;69(9):1057-65.
  48. Wang MJ, Huang HM, Hsieh SJ, Jeng KC, Kuo JS., Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation., J Neuroimmunol. 2001 Jan 1;112(1-2):28-34.

Reducing LDL levels resveratrol research

  1. Do GM, Kwon EY, Kim HJ, Jeon SM, Ha TY, Park T, Choi MS., Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice., Biochem Biophys Res Commun. 2008 Sep 12;374(1):55-9.
  2. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA., Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006 Aug;55(8):2180-91.
  3. Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML., Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress., J Nutr. 2005 Aug;135(8):1911-7.
  4. Rimando AM, Nagmani R, Feller DR, Yokoyama W., Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters., J Agric Food Chem. 2005 May 4;53(9):3403-7.
  5. Zern TL, West KL, Fernandez ML., Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs., J Nutr. 2003 Jul;133(7):2268-72.
  6. Pal S, Ho N, Santos C, Dubois P, Mamo J, Croft K, Allister E., Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells., J Nutr. 2003 Mar;133(3):700-6.
  7. Weisburger JH., Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea., Food Chem Toxicol. 1999 Sep-Oct;37(9-10):943-8.
  8. Frémont L, Belguendouz L, Delpal S., Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci. 1999;64(26):2511-21.

Triglyceride levels and resveratrol resveratrol research

  1. Shan T, Wang Y, Wu T, Guo J, Liu J, Feng J, Xu Z., Porcine adipose triglyceride lipase complementary deoxyribonucleic acid clone, expression pattern, and regulation by resveratrol., J Anim Sci. 2008 Aug;86(8):1781-8.
  2. Cho IJ, Ahn JY, Kim S, Choi MS, Ha TY., Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters., Biochem Biophys Res Commun. 2008 Feb 29;367(1):190-4.
  3. Wang Z, Zou J, Cao K, Hsieh TC, Huang Y, Wu JM., Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels., Int J Mol Med. 2005 Oct;16(4):533-40.
  4. Ilan E, Tirosh O, Madar Z., Triacylglycerol-mediated oxidative stress inhibits nitric oxide production in rat isolated hepatocytes., J Nutr. 2005 Sep;135(9):2090-5.
  5. Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML., Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress., J Nutr. 2005 Aug;135(8):1911-7.
  6. Aronis A, Madar Z, Tirosh O., Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis., Free Radic Biol Med. 2005 May 1;38(9):1221-30.
  7. Miura D, Miura Y, Yagasaki K., Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats., Life Sci. 2003 Aug 1;73(11):1393-400.

Vasorelaxing and lowering heart disease resveratrol research

  1. Soylemez S, Gurdal H, Sepici A, Akar F., The effect of long-term resveratrol treatment on relaxation to estrogen in aortae from male and female rats: Role of nitric oxide and superoxide., Vascul Pharmacol. 2008 Jul 4.
  2. Zamblé A, Martin-Nizard F, Sahpaz S, Hennebelle T, Staels B, Bordet R, Duriez P, Brunet C, Bailleul F., Vasoactivity, antioxidant and aphrodisiac properties of Caesalpinia benthamiana roots., J Ethnopharmacol. 2008 Feb 28;116(1):112-9.
  3. Calderone V, Martelli A, Testai L, Martinotti E, Breschi MC., Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels., Naunyn Schmiedebergs Arch Pharmacol. 2007 Mar;375(1):73-80.
  4. Yoo MY, Oh KS, Lee JW, Seo HW, Yon GH, Kwon DY, Kim YS, Ryu SY, Lee BH., Vasorelaxant effect of stilbenes from rhizome extract of rhubarb (Rheum undulatum) on the contractility of rat aorta., Phytother Res. 2007 Feb;21(2):186-9.
  5. Granados-Soto V., Pleiotropic effects of resveratrol., Drug News Perspect. 2003 Jun;16(5):299-307.
  6. Orallo F, Alvarez E, Camińa M, Leiro JM, Gómez E, Fernández P., The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption., Mol Pharmacol. 2002 Feb;61(2):294-302.
  7. Mizutani K, Ikeda K, Kawai Y, Yamori Y., Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP)., J Nutr Sci Vitaminol (Tokyo). 1999 Jan;45(1):95-106.
  8. Chen CK, Pace-Asciak CR., Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta., Gen Pharmacol. 1996 Mar;27(2):363-6.
  9. Fitzpatrick DF, Hirschfield SL, Coffey RG., Endothelium-dependent vasorelaxing activity of wine and other grape products., Am J Physiol. 1993 Aug;265(2 Pt 2):H774-8.

Collagen formation collagen formation

  1. Mizutani, K., Ikeda, K., Kawai, Y., and Yamori, Y., Resveratrol Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3 Cells., Biochem Biophys Res Commun 253 (1998): 859—863.
  2. Rucinski M, Ziolkowska A, Hochol A, Pucher A, Macchi C, Belloni AS, Nussdorfer GG, Malendowicz LK., Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1alpha gene expression in primary culture of rat calvarial osteoblast-like cells., Int J Mol Med. 2006 Oct;18(4):565-70.
  3. Ziolkowska A, Rucinski M, Pucher A, Tortorella C, Nussdorfer GG, Malendowicz LK., Expression of osteoblast marker genes in rat calvarial osteoblast-like cells, and effects of the endocrine disrupters diphenylolpropane, benzophenone-3, resveratrol and silymarin., Chem Biol Interact. 2006 Dec 15;164(3):147-56.
  4. Chanvitayapongs, S., Draczynska-Lusiak, B., and Sun, A. Y., Amelioration of Oxidative Stress by Antioxidants and Resveratrol in PCI2 Cells., Neuroreport 8 (1997): 1499—1502.
  5. Leung, A., and Mo, Z., Protective Effects of Polydatin, an Active Compound from Polygonum cuspidatum, on Cerebral Ischemia Damage in Rats., Chin Pharm Bull 12 (1996): 128-129.
  6. Nigdikar, S. V., Williams, N. R., Griffin, B. A., and Howard, A. N., Consumption of Red Wine Polyphenols Reduces the Susceptibility of Low-Density Lipoproteins to Oxidation in Vivo., Amer I Clin Nutr 68 (1998): 258—265.
  7. Sato, M., Maulik, C., Bagchi, D., and Das, D. K., Myocardial Protection by Protykin, a Novel Extract of trans-Resveratrol and Emodin., Free Radical Research 32 (2000): 135—144.
  8. Frankel, F., Waterhouse, A. L., and Kinsella, J. F., Inhibition of Human LDL Oxidation by Resveratrol., The Lancet 341 (1993): 1103—1104.
  9. Han, Y. N., Ryu, S. Y., and Han, B. H., Antioxidant Activity of Resveratrol Closely Correlates with its Monoamine Oxidase-A Inhibitory Activity., Arch Pharm Res 13 (1990): 132—135.
Ageless herbal product range

Our Ageless herbal product range

Skin care

  • Healing cream
    • To assist in wound healing while soothing skin complaints – such as eczema and psoriasis, acne and piles and moisturizing and protecting the skin. This product has shown its effectiveness over a wide range of problems and judging from sales over more than a decade – it is the trusted healing cream to help with all mishaps, allergic reactions, irritated, burning, itchy and uncomfortable skin conditions.
  • Face wash
    • This face wash will properly clean your face and remove all impurities and environmental pollutants, without drying the skin. It contains eight herbal extracts to help promote a clear, vital and healthy complexion and a younger looking skin.
  • Moisturizing day cream
    • This day cream is formulated to help fight the signs of aging on various fronts. It helps to reduce free radical damage which, if left unchecked, leads to premature aging. The herbal extracts help to promote cell rejuvenation and regeneration and provide moisture and hydration to the skin.
  • Nourishing night cream
    • This nourishing night cream penetrates the skin extremely well and does not make the skin feel oily. It contains a host of herbal extracts to help in the fight against premature aging and has added vitamin E as well. Apart from the moisturizing effect and the anti-aging properties it also softens and smoothes the skin.
  • Eye gel
    • An effective refreshing eye gel to help reduce puffiness and dark rings around the eyes, while fighting wrinkles and lines. This is a very clever combination of herbal extracts and the base formula has its roots in a clinically proven formula.
  • Mud face mask
    • With this skin treatment product we combined a special selection of herbs in a base of thermal mud with oligoelements. This recommended weekly treatment will boost circulation to the skin, help to fight wrinkles and lines, improve firmness while at the same time improving suppleness and elasticity of the skin.

 

Hair care

  • Shampoo with rosemary extract + 7 other herbals
    • Our shampoo is in a class of its own – and granted – it is far more expensive than cheap supermarket shampoos, but no other shampoo has the active ingredients we have in our shampoo. The rosemary will boost the health of the hair and scalp, while the other seven herbal extracts will help strengthen the hair and make it shine, increase the volume and make it manageable.
  • Rosemary hair treatment conditioner
    • We have found that this hair conditioner should really be used as a conditioning treatment. This then removes the need to condition the hair every time you wash – and can be used once a month. It is a superb hair tonic and helps in the control of sebum secretion of the scalp. Although not formulated for dandruff – the ingredients will assist with this as well, while supporting the health of the scalp.

 

Specialized herbal gels and lotions

  • Hand and body lotion
    • When formulating this hand and body lotion we created a rich nourishing, protecting and reviving lotion, which will not leave the skin oily or tacky, but will create a well moisturized, hydrated and supple skin. After applying this lotion it will quickly be absorbed by the skin, leaving it silky soft, smooth and well moisturized.
  • Stretch mark gel
    • Although nothing can remove already formed stretch marks (only surgery can do that) – thousands of satisfied clients confirm that this gel improves the appearance of old stretch marks. The gel will help in PREVENTING stretch marks (a 92% success rate) and is used with great success by expectant mothers and body builders who may form marks when bulking-up. The formula of this gel is based on clinical studies done in France, to which we added other herbal extracts.

 

Herbal supplements

 

Other products

  • Jojoba oil
    • This liquid golden ester not only moisturizes and penetrates the skin but also helps to fight wrinkles and lines while promoting a clear and unblemished skin. Jojoba does not clog the pores but helps to restore skin elasticity and smoothness. It will leave the skin supple and velvety soft without any oiliness and can be used neat on the skin.
  • Almond oil
    • This light and deeply moisturizing oil has a softening effect on the skin and can be used on the face and body. Almond oil has excellent emollient properties and helps to balance water and moisture loss in the skin. It can be used neat on the skin and also makes an excellent massage base.
pci dss compliant
website and shopping security
sallamander concepts
Ageless essential oils
Agelesshealth South African herbal and essential oils products

 


Information contained on this website is for general information purposes only
and must not be used to treat or diagnose medical conditions.


All health problems must be referred to a health care professional.

Statements made regarding the products, ingredients and general information
have not been evaluated by the FDA or SAHPRA and should not be seen as health claims.


All ingredients used in our products are safe and are not banned, controlled or restricted.

All products are manufactured in licensed laboratories following strict GMP and ISO standards.

Our site was last updated on 1 January 2024

© Sallamander Manufacturing CC 2006 - 2024