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Resveratrol has been demonstrated to help inhibit the initiation, promotion, and progression stages of
cancerous growths and tumors.
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Although we make the statement that resveratrol can assist in some medical problems – PLEASE NOTE – we do no advocate or claim that
resveratrol will cure cancer or
cure any other disease – although there has been some very promising research done on various health problems and diseases and the effect that resveratrol has on them, but this needs to be further investigated before such claims can be made. |
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Other pages dealing with the beneficial effects of resveratrol: |
Currently, numerous preclinical findings suggest resveratrol as a promising compound for
cancer prevention and treatment.
A chemopreventive agent (preventing cancer) can operate via different mechanisms, such as the inhibition of the metabolic activation of
carcinogenic compounds, the stimulation of reactive metabolite detoxification, the prevention of their interaction with
cell DNA and the
suppression of tumor progression.
Resveratrol is able to act on each of these mechanisms and it can simultaneously
inhibit promutagen bioactivation,
stimulate carcinogen detoxification and
prevent the organism against the adverse effects of
diverse environmental toxicants.
Resveratrol may also possess a chemotherapeutic potential – that is to
help treat cancer. It
suppresses growth of various cancer cell lines, partly by an inhibition of DNA polymerase and ribonucleotide reductase and partly by
inducing cell cycle arrest or apoptosis (killing of cells when necessary). Intraperitoneal injections also
decrease the number of tumor cells in a Yoshida AH-130 ascite hepatoma rat model.
Dr. Jang and his collaborators published cutting-edge research results in Science in January 1977, considered the top-rated peer-reviewed journal. Their work showed that resveratrol functions as a
potent anti-mutagen. Its beneficial effects included the induction of Phase II
drug-metabolizing enzymes (anti-initiation activity), inhibition of cyclooxygenase and hydroperoxidase functions (anti-promotion activity), and the induction of human promyelocytic-leukemic cell differentiation (anti-progression activity).
Therefore - resveratrol helps to
inhibit the three prime stages of carcinogenesis (literally meaning
the creation of cancer):
initiation, promotion, and progression.
Resveratrol also showed to inhibit the development of
preneoplastic lesions in
carcinogen-treated mouse mammary glands in vitro, and inhibited tumorigenesis in a mouse
skin cancer model.
Resveratrol inhibited cancer initiation by reducing in vitro
free radical formation when human
leukemia cells were treated with TPA effective dose, inhibiting the mutagenic response when Salmonella typhimurium cells were treated with a noxious polycyclic aromatic hydrocarbon DMBA, and inducing quinone reductase activity in cultured mouse hepatoma cells. This last observation is highly significant because Stage II enzymes such as quinone reductase are capable of
detoxifying carcinogens. This might all sound way over the top – but is simply means that in the studies done, resveratrol showed some amazing capabilities in
fighting cancer.
Resveratrol also inhibited cancer promotion in mice by inhibiting cyclooxygenase activity of COX-1 and hydroperoxidase activity of COX-1 and COX-2 and reducing pedal edema both in the acute (3 to 7 hours) and chronic (24 to 144 hours) phases.
Cyclooxygenase activity inhibition is relevant to
cancer chemoprevention because it catalyzes the conversion of arachidonic acid to pro-inflammatory substances, which can
stimulate tumor cell growth and
suppress immune surveillance. Cyclooxygenase can also
activate carcinogens to forms that damage cellular material.
Considerable evidence has accumulated suggesting that COX-2 is important in
tumorigenesis and that targeted inhibition of CQX-2 may be an innovative approach to preventing cancer and
treating inflammation.
Treatment of human mammary epithelial cells with phorbol ester (PMA)- mediated induction of COX-2 induces a marked increase in production of
prostaglandin E2. The enhanced synthesis of
prostaglandins can favor the growth of malignant cells by
increasing cell proliferation.
Resveratrol suppresses PMA-mediated increases in
COX-2 mRNA and protein. Additionally, nuclear runoffs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that also was inhibited by resveratrol. In this way, resveratrol can serve as a potential natural product to
prevent cancer by targeted inhibition of COX-2.8
Resveratrol also delayed the onset of cancer progression by inducing expression of nitroblue tetrazolium reduction activity, a marker of granulocyte formation, and nonspecific acid esterase activity, a marker of macrophage formation; and inhibiting incorporation of [3H] thymidine, a marker of terminal differentiation to a non-proliferative phenotype.
Resveratrol was also found to possess chemopreventive activity by inhibiting ribonucleotide reductase and cyclooxygenase-28 and by inhibiting cellular events associated with cell proliferation and
tumor initiation, promotion, and
progression.
Ribonucleotide reductase is a protein enzyme complex that catalyzes the reduction of ribonucleotide into the deoxyribonucleotides required for DNA synthesis. Basically, this enzyme provides proliferating cells with the deoxynucleotides required for DNA synthesis. By inhibiting this enzyme, resveratrol exhibits antiproliferating activity and so
inhibits cancer cell proliferation and differentiation.
A very significant decrease (25 percent) in the tumor cell content resulted when rats inoculated with a
fast-growing tumor (the Yoshida AH-130 ascites hepatoma) were given resveratrol in vivo. The researchers were able to show that resveratrol caused
apoptosis (programmed cell death) in the tumor cell population, which resulted in a decreased cell number of
cancer cells.
Resveratrol was also found to
induce apoptotic (programmed) cell death in
human leukemic HL-60 cells and in
T47D breast carcinoma cells at doses minimally toxic to normal peripheral blood lymphocytes. Resveratrol-induced apoptosis is mediated via caspase activation inhibitable by tetrapeptide caspase inhibitors.
Furthermore, resveratrol enhances CD95L expression and induces CD95, signaling
dependent cell death in both tumor cell lines. The chemopreventive activity of resveratrol could be explained by the induction of CD95-dependent
apoptotic cell death in tumor cells, leading to the
inhibition of tumor initiation and progression.
Dr. Ragione and his colleagues investigated the activity of resveratrol on proliferation and differentiation of the human promyelocitic HL-60 cells. A low concentration causes a complete arrest of proliferation and a rapid induction of differentiation towards a myelo-monocytic phenotype. Resveratrol induces a complete and reversible cell cycle arrest at the S-phase checkpoint. These studies demonstrated that resveratrol is a potential candidate for the development of
anti-cancer treatment as well as for inhibiting lymphocyte proliferation during immunosuppressive therapies.
From the above you will see that a variety of trials have been
done on cancer as such, but a large volume of research has also been undertaken on how
resveratrol influence cancer cells in the
human breast cells, and although it cannot be claimed yet that
resveratrol arrests the development of breast cancer, or is
an effective treatment for breast cancer – all the research points to very interesting and positive effects that may still need further investigation. It can however be safely assumed that resveratrol is a supplement of choice when battling with this disease. CLINICAL REFERENCES
One of the cancers that men fear most must be
prostate cancer, as it can have such a direct influence on their
sexual functioning. It must however be kept in mind that if
prostate cancer is detected and treated early, the prognosis is excellent.
A variety of trials and research have also been done on the positive effect that
resveratrol has on prostate cancer – and although more studies may be needed to conclusively show that there is a place for
resveratrol in the treatment of prostate cancer, it can be fairly
taken that resveratrol can be most beneficial when
fighting prostate cancer. CLINICAL REFERENCES
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